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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 5d

Variant Effects Seminar Series
October and November lineup! Join us!
ℹ️https://www.varianteffect.org/seminar-series/

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Wellcome Sanger Institute @sangerinstitute.bsky.social · 6d

This role, based at Sanger, will lead on the communications for the Atlas of Variant Effects Alliance - an initiative that is mapping the effects of all the possible variants of human genes 🧬

This is a part-time role, closing on 14th Oct.
More info ⤵️
sanger.wd103.myworkdayjobs.com/WellcomeSang...

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Irene Gallego Romero @ee-reh-neh.bsky.social · 7d

I'm stoked to be organising next year's MSS right here in beautiful Melbourne! We know Australia is very far away, and we're working hard to make sure we can support as many ECRs to attend as possible, so please do register and apply for a travel award!

Atlas of Variant Effects Alliance @varianteffect.bsky.social · 12d

📣Call for Abstracts
for the Mutational Scanning Symposium! #VariantEffect26
🗓️ March 25-27, 2026
📍 Melbourne, Australia (and online!)
📝 Submit your abstract (deadline is Nov 2nd, 2025!)
➡️ Registration is also now open!!
ℹ️ www.mss2026.org

#FunctionalGenomics #Symposium #Australia #CallForAbstracts

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Lara Muffley @muffley.bsky.social · 7d

@varianteffect.bsky.social @sangerinstitute.bsky.social #JobOpening This person would work closely with me. Reach out if you are interested in learning more!

Atlas of Variant Effects Alliance @varianteffect.bsky.social · 7d

We are #Hiring!
Communications role for our Global Alliance! 🌍🧬
Please share this post with your network, or apply if you are interested!
📍 Location: Hinxton, England
🕒 Part-time role
ℹ️ sanger.wd103.myworkdayjobs.com/en-US/Wellco...

#ScienceJobs #Communications #Genomics
#PartTimeRole #UKJobs

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 8d

We are hiring! Communications role for our Global Alliance! sanger.wd103.myworkdayjobs.com/en-US/Wellco... #job #hiring #Communications Hinxton, Cambridgeshire UK

Scientific Communications Manager -Part Time

Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenge...

sanger.wd103.myworkdayjobs.com

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Lara Muffley @muffley.bsky.social · 12d

Submit your abstract for the upcoming Mutational Scanning Symposium (deadline is Nov 2nd, 2025!)
General info: www.mss2026.org
Abstract submission form: docs.google.com/forms/d/e/1F...

Atlas of Variant Effects Alliance @varianteffect.bsky.social · 12d

📣Call for Abstracts
for the Mutational Scanning Symposium! #VariantEffect26
🗓️ March 25-27, 2026
📍 Melbourne, Australia (and online!)
📝 Submit your abstract (deadline is Nov 2nd, 2025!)
➡️ Registration is also now open!!
ℹ️ www.mss2026.org

#FunctionalGenomics #Symposium #Australia #CallForAbstracts

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · Sep 3

Next up! Two applications of MAVE!
🧬 DNA damage repair & cancer: Shelby Hemker (@jacobkitzman.bsky.social lab UMich) measures DNA repair of MUTYH variants.
🦠Antibiotic resistance: @kroman.bsky.social (‪@synplexity.bsky.social Univ. of Oregon) decodes how mutations drive resistance in DHFR.

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 20d

This is one not to miss!
We look forward to seeing you all in Melbourne. #VariantEffect26
⏰Abstract deadline is Nov 2nd 2025.

UW Genome Sciences @uwgenome.bsky.social · 20d

Registration is now open for the Mutational Scanning Symposium!!
25-27 March 2026
Melbourne, Australia
Matt Hurles (Wellcome Sanger) and Maitreya Dunham (University of Washington)
Deadline for abstract submissions: 2 November 2025.
www.mss2026.org

MSS26

Mutational Scanning Symposium 2026, 25-27 March, Melbourne

www.mss2026.org

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Science Friday @scifri.bsky.social · 19d

Today, scientists know that genetics plays a role in many conditions and diseases. But back in the ’90s, geneticist Mary-Claire King was the first to link a gene to an inherited form of a common cancer.

A Trailblazing Geneticist Reflects On Her Life And Work

Dr. Mary-Claire King was the first to link a gene to hereditary cancer risk with the identification of BRCA1. She was just getting started.

buff.ly

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 20d

Registration is now open for the Mutational Scanning Symposium!! This is one not to miss. Invited speakers include @mehurles.bsky.social @sangerinstitute.bsky.social @maitreya.bsky.social @uwgenome.bsky.social
#VariantEffect26 Register soon for the early bird rate!
ℹ️➡️https://www.mss2026.org

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 19d

🧬 Out this month in Nature Reviews Cardiology: A powerful look at how multiplexed assays of variant effects (MAVEs) are reshaping our understanding of cardiovascular disease genetics. Contributors include members of the AVE Alliance.
📑 www.nature.com/articles/s41...
#Cardiology #FunctionalGenomics

Creating an atlas of variant effects to resolve variants of uncertain significance and guide cardiovascular medicine - Nature Reviews Cardiology

In this Review, Roden and co-workers describe how multiplexed assays of variant effects can be used for high-throughput functional assessment of nearly all coding variants in a target sequence to impr...

www.nature.com

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UW Genome Sciences @uwgenome.bsky.social · 28d

Multiplex and multimodal mapping of variant effects in secreted proteins via MultiSTEP
www.nature.com/articles/s41...

Multiplex and multimodal mapping of variant effects in secreted proteins via MultiSTEP - Nature Structural & Molecular Biology

Multiplexed assays of variant effect can resolve clinical variants but are incompatible with secreted proteins. Here Popp et al. develop MultiSTEP, a generalizable surface-tethering method to assess v...

www.nature.com

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 22d

MSS is a cornerstone event for the functional genomics community. Did you know that the Mutational Scanning Symposium has been held eight times since 2017? We have an amazing community! Join us next year in Australia! www.mss2026.org (Registration to open soon). #VariantEffect26

The image is divided into two main sections. The top half contains two group photos labeled "Group photo 2024" on the left and "Group photo 2025" on the right. The 2024 group photo shows a large gathering of people indoors with banners featuring red and orange designs in the background. Participants are standing on a beige-tiled floor. The 2025 group photo depicts another gathering of people outdoors on a wooden deck, set against a modern architectural backdrop.

The bottom half of the image features an infographic in blue and white, with the text "The Mutational Scanning Symposium has been held 8 times since 2017" prominently displayed. Below this, a timeline of events from 2017 to 2026 is shown with numbered circles indicating each year. Information about each symposium location is provided: Seattle, USA (2017, 2019, 2020), Virtual Only (2021), Toronto, Canada (2022), Hinxton, UK (2023), Boston, USA (2024), Barcelona, Spain (2025), and a planned event in Melbourne, Australia (2026).

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 23d

The 9th Annual Mutational Scanning Symposium will be held in Melbourne, Australia March 25-27, 2026 🌟 #VariantEffect26
www.mss2026.org Registration will open soon!!!!

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · 23d

📢 Empower Genomic Innovation with Your Sponsorship! 🧬
We are looking for generous #sponsors to support the upcoming Mutational Scanning Symposium. #VariantEffect26
ℹ️ www.mss2026.org For sponsorship inquiries, please contact 📩 [email protected]

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Lara Muffley @muffley.bsky.social · 29d

brotmanbaty.org/news/new-vis...

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · Sep 2

Variant Effects Seminar is today! (9am Pacific)
www.varianteffect.org/seminar-seri...

Atlas of Variant Effects Alliance @varianteffect.bsky.social · Aug 7

Coming up in September!
➡️Christina Kajba @ckajba.bsky.social & Michael Herger @michaelherger.bsky.social — pooled prime editing screens in haploid human cells
➡️Jon Acosta — multiplexed in vivo base editing screens
#GeneticVariants #PrimeEditing
ℹ️https://www.varianteffect.org/seminar-series/

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · Aug 29

Interested in viewing a talk from a previous Mutational Scanning Symposium?

Visit our youtube channel.
📺 🍿 www.youtube.com/@cmap_cegs84...

@isabellease.bsky.social 's wonderful #VariantEffect25 illustrations can be found here. 🎨 isabellezane.bio

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · Aug 29

Critical Assessment of Genome Interpretation (CAGI) challenges are live! 🧬💻
genomeinterpretation.org/cagi7-challe...
A total of 12 challenges have launched Including #DeepMutationalScanning Challenges
⏰ Deadlines approaching! #CAGI #GenomeInterpretation #VariantEffect

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · Aug 19

Why yes! You can watch previous Variant Effects Seminar Series talks on our YouTube channel!
ℹ️ www.varianteffect.org/previous-sem... 📺 www.youtube.com/playlist?lis...

#Genomics #Seminar #EarlyCareerResearchers #ScientificSeminar #PrecisionMedicine

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Lara Muffley @muffley.bsky.social · Aug 7

Pinot! 🐈 ❤️

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · Aug 4

‪🗓️ Join us tomorrow! August 5
with @nurdankuru.bsky.social (CSHL) @cshlnews.bsky.social
and Ferdy van Geest (ErasmusMC)
#Genetics #RareDisease #MedicalGenetics
ℹ️ www.varianteffect.org/seminar-seri...

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Atlas of Variant Effects Alliance @varianteffect.bsky.social · Aug 4

Ever wondered how your genes shape your health? Dive into the Variants and Us (VUS) Podcast—where cutting-edge science meets real-world impact.
🎧 varianteffect.org/podcast/
#Genetics #RareDisease #VariantEffect #SciencePodcast #PersonalizedMedicine

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Doug Fowler @dougfowler.bsky.social · Jul 21

Interested in using functional data to understand clinical variants? Been hunting for a good review of the topic? We just wrote one! rdcu.be/exaEU

Multiplexed assays of variant effect for clinical variant interpretation

Nature Reviews Genetics - Multiplexed assays of variant effect (MAVEs) are highly scalable experimental approaches used to generate functional data for genetic variants. In this Review, McEwen et...

www.nature.com

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Sriram Pendyala @treependyala.bsky.social · Jul 7

🚨 Most variant screens measure growth or abundance. What do they miss? That variants impact a spectrum of protein and cellular phenotypes. Variant in situ sequencing (VIS-seq) finds what’s missing: image cells 🔬 first, decode later, revealing multi-scale phenotypes for thousands of variants.👇

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