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Reposted by Muzumdar Lab

Yale Cancer Center @yalecancer.bsky.social · 2d

A new study led by Dr. Prasanna Ananth explores how the
21st Century Cures Act—giving patients immediate access to electronic health records, impacts #cancer care in the pediatric oncology population.
yalecancercenter.org/news-article...

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Muzumdar Lab @muzumdarlab.bsky.social · 12d

Register now! www.eventbrite.com/e/the-sixth-...

The Sixth Annual Diabetes & Cancer Interface Symposium: Connecting the Dots

City of Hope’s annual Diabetes & Cancer Interface Symposium explores the research and treatment links between obesity, diabetes, and cancer.

www.eventbrite.com

Muzumdar Lab @muzumdarlab.bsky.social · 12d

Excited to present at the sixth annual #ConnectingTheDots symposium with @cityofhope.bsky.social. Join us Nov. 7 for a deep dive into the #diabetes-#cancer interface.

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Reposted by Muzumdar Lab

Nature Genetics @natgenet.nature.com · Aug 27

🎉PUBLISHED @natgenet.nature.com

📰Tracing the evolution of single-cell 3D genomes in Kras-driven #cancers.

By Miao Liu, @muzumdarlab.bsky.social, @sstevenwang.bsky.social and colleagues.

⬇️

www.nature.com/articles/s41...

Tracing the evolution of single-cell 3D genomes in Kras-driven cancers - Nature Genetics

This study uses chromatin tracing to identify alterations in single-cell 3D genome conformation during the progression of Kras-driven mouse lung adenocarcinoma and pancreatic ductal adenocarcinoma, an...

www.nature.com

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Muzumdar Lab @muzumdarlab.bsky.social · Aug 26

7/ This was a close collaboration with @sstevenwang.bsky.social. Kudos to #MiaoLiu, #SherryAgabiti, and #ShengyanJin for leading the effort with critical collaboration from @christianfruiz.bsky.social @jeffreytownsend.bsky.social @yalecancer.bsky.social and funding from #NCI @theaacr.bsky.social

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Muzumdar Lab @muzumdarlab.bsky.social · Aug 26

6/ 🚀 Take-home: The first single-cell 3D genome atlas of cancer in situ. Stage-specific shifts + new gene regulators = a 3D genomics roadmap for potential biomarkers and targets for precision oncology.

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Muzumdar Lab @muzumdarlab.bsky.social · Aug 26

5/ 🤖 The twist: 3D genome signatures don’t just classify tumor states—they add predictive & prognostic power beyond RNA-seq alone 📈. Compartment changes flagged key genes, spotlighting Rnf2 as a novel regulator of cancer genome folding.

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Muzumdar Lab @muzumdarlab.bsky.social · Aug 26

4/ 📊 The discovery: 3D genome changes are non-linear and exhibit convergent evolution across tumors. Tumors go through stage-specific shifts in compaction, compartment identity & heterogeneity—with a “structural bottleneck” early on. ⏳

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Muzumdar Lab @muzumdarlab.bsky.social · Aug 26

3/ 🛠 The tech: Using chromatin tracing, we imaged hundreds of loci across all 19 mouse autosomes in situ, mapping 3D genomic evolution in single #LungCancer and #PancreaticCancer cells within intact tissues. 📸

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Muzumdar Lab @muzumdarlab.bsky.social · Aug 26

2/ 🔍 Why it matters: Cancer isn’t just about mutations—it’s also how DNA folds in 3D. This study maps genome architecture from normal → pre-cancer → advanced cancer, at single-cell resolution.

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Muzumdar Lab @muzumdarlab.bsky.social · Aug 26

1/ 🚨 New in Nature Genetics @naturegenet.bsky.social:  “Tracing the evolution of single-cell 3D genomes in Kras-driven cancers” 🧬🧩 👉 The first atlas of how genome folding changes during cancer progression. www.nature.com/articles/s41...

Tracing the evolution of single-cell 3D genomes in Kras-driven cancers - Nature Genetics

This study uses chromatin tracing to identify alterations in single-cell 3D genome conformation during the progression of Kras-driven mouse lung adenocarcinoma and pancreatic ductal adenocarcinoma, an...

www.nature.com

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Muzumdar Lab @muzumdarlab.bsky.social · Aug 26

💡 Cancer cells don’t just mutate—they reorganize their DNA in 3D space.
Our new study shows how the genome’s folding pattern shifts as tumors progress, cell by cell 🧩🧬.
It’s the first 3D genome atlas of cancer progression.
Thread 👇

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Reposted by Muzumdar Lab

Bluma Lesch @ambystoma22.bsky.social · Aug 20

New paper on the role of H3K4me3 at enhancers! We (led by Haoming Yu) used dCas9 epigenome editing to add H3K4me3 to intergenic enhancers. This was (1) sufficient to turn up transcription at open, active regions and (2) has no effect on target gene transcription. genesdev.cshlp.org/content/earl...

H3K4me3 amplifies transcription at intergenic active regulatory elements

A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields

genesdev.cshlp.org

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Reposted by Muzumdar Lab

Yale Cancer Center @yalecancer.bsky.social · Aug 19

New @natgenet.nature.com study from @muzumdarlab.bsky.social + @sstevenwang.bsky.social
maps 3D genomes in KRAS-driven lung & pancreatic #cancer, revealing stage-specific changes + potential biomarkers.

➡️ yalecancercenter.org/news-article...

Cancer's Progress Detailed by 3D Genomic Maps

Using new technology, Yale researchers examine cancer progression in single cells to visualize and understand its evolution from pre-cancerous to advanced

yalecancercenter.org

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Muzumdar Lab @muzumdarlab.bsky.social · Aug 19

Wonderful to collaborate with you and the team on this study, Steven!

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Reposted by Muzumdar Lab

Siyuan (Steven) Wang @sstevenwang.bsky.social · Aug 19

This work was done in collaboration with my @yaleschoolofmed.bsky.social colleague Professor Mandar Muzumdar @muzumdarlab.bsky.social and co-led by Drs. Miao Liu, Shengyan Jin, and Sherry Agabiti. Congrats to all authors! Also thank you National Cancer Institute for funding this work! 10/12

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Reposted by Muzumdar Lab

Siyuan (Steven) Wang @sstevenwang.bsky.social · Aug 19

Link to YSM News article about this work: medicine.yale.edu/news-article... 12/12

Cancer's Progress Detailed by 3D Genomic Maps

Using new technology, Yale researchers examine cancer progression in single cells to visualize and understand its evolution from pre-cancerous to advanced

medicine.yale.edu

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Reposted by Muzumdar Lab

Siyuan (Steven) Wang @sstevenwang.bsky.social · Aug 19

Glad to share our latest publication in Nature Genetics: Tracing the evolution of single-cell 3D genomes in Kras-driven cancers. In this work, we generated the first single-cell 3D genome atlases of any cancer using any technique. 1/12

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Muzumdar Lab @muzumdarlab.bsky.social · Aug 18

Excited to share our latest paper in @natgenet.nature.com with #SiyuanWang @yale.edu on the evolution of 3D genome organization in 🐁 models of #LungCancer and #PancreaticCancer. Kudos to #MiaoLiu #SherrySu! @yalecancer.bsky.social www.nature.com/articles/s41...

Tracing the evolution of single-cell 3D genomes in Kras-driven cancers - Nature Genetics

This study uses chromatin tracing to identify alterations in single-cell 3D genome conformation during the progression of Kras-driven mouse lung adenocarcinoma and pancreatic ductal adenocarcinoma, an...

www.nature.com

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Reposted by Muzumdar Lab

christianfruiz.bsky.social @christianfruiz.bsky.social · Jul 16

🎉 So proud of my wife
Natasha Pinto Medici on her latest co–first author paper in @ScienceTransMed!
🚀 Her team introduces TMAB3 — a tumor-targeted, RNA-binding antibody that delivers RNA directly into tumors after systemic injection.
www.science.org/doi/10.1126/...

Systemic administration of an RNA binding and cell-penetrating antibody targets therapeutic RNA to multiple mouse models of cancer

A cell-penetrating and RNA binding antibody forms noncovalent complexes with an immunogenic RNA to target tumors and achieve antitumor efficacy.

www.science.org

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Muzumdar Lab @muzumdarlab.bsky.social · Jul 16

Stellar flash talk and poster presentation on #ubiquitination regulators in #KRAS inhibitor resistance by our own #CassieMarkham @faseborg.bsky.social Protein Phosphorylation! @yalecancer.bsky.social

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Muzumdar Lab @muzumdarlab.bsky.social · Jul 15

Way to go, @xiangyuge.bsky.social, for a fantastic talk on how #PI3K governs resistance to #KRAS inhibition in #PancreaticCancer cells @faseborg.bsky.social Protein Phosphorylation! @yalepathology.bsky.social @yalecancer.bsky.social. Check out her preprint: www.biorxiv.org/content/10.1...

Phosphoinositide 3-kinase regulates wild-type RAS signaling to confer resistance to KRAS inhibition

Despite the availability of RAS inhibitors and the dependence of >90% of pancreatic ductal adenocarcinomas (PDAC) on oncogenic KRAS mutations, resistance to KRAS inhibition remains a serious obstacle....

www.biorxiv.org

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Muzumdar Lab @muzumdarlab.bsky.social · Jun 25

8/👏 Kudos to lead author @xiangyuge.bsky.social with key contributions from Jaffar, Wenxue, Cassie, @christianfruiz.bsky.social, @moitrayee-lab.bsky.social, and Yansheng. #YCBI #YaleGenetics #YalePharm @yalecancer.bsky.social @lustgarten.org

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Muzumdar Lab @muzumdarlab.bsky.social · Jun 25

7/ 🧠 Big picture:
Our findings reveal that #PI3K can act upstream of wild-type RAS to mediate resistance to #KRAS inhibition.
This refines our understanding of #RAS pathway plasticity and provides new insights into #DrugResistance mechanisms.
Read more: www.biorxiv.org/content/10.1...

Phosphoinositide 3-kinase regulates wild-type RAS signaling to confer resistance to KRAS inhibition

Despite the availability of RAS inhibitors and the dependence of >90% of pancreatic ductal adenocarcinomas (PDAC) on oncogenic KRAS mutations, resistance to KRAS inhibition remains a serious obstacle....

www.biorxiv.org

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Muzumdar Lab @muzumdarlab.bsky.social · Jun 25

6/ 💡 Therapeutic insight:
Co-inhibition of PI3K + KRAS abrogates bypass and kills resistant cells.
This gives a mechanistic rationale for dual targeting in KRAS-driven cancers.

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