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Natalie Matosin @nataliematosin.bsky.social · 4d

~dogfish

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Natalie Matosin @nataliematosin.bsky.social · 7d

Home 💜

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Natalie Matosin @nataliematosin.bsky.social · 7d

Well not most of the day, but try to get out of the house and down there daily!

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Natalie Matosin @nataliematosin.bsky.social · 7d

I am very lucky to call this my backyard!

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Natalie Matosin @nataliematosin.bsky.social · 12d

Our findings highlight astrocytes as crucial players in how exposure to severe adversity raises risk to psychopathology and position them as strategic pharmacological targets for future intervention strategies.

Read more here: www.biorxiv.org/content/10.1...

Astrocytic glutamate regulation is shaped by adversity and glucocorticoid signalling

Astrocytes are a brain cell type vulnerable to the effects of stress and the development of psychiatric-like phenotypes in animals, yet how this translates to humans is unclear. Here, we probed the di...

www.biorxiv.org

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Natalie Matosin @nataliematosin.bsky.social · 12d

Human pluripotent stem cell-derived astrocytes from both two- and three-dimensional models confirmed that glutamate signalling is directly impacted by glucocorticoid activation.

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Natalie Matosin @nataliematosin.bsky.social · 12d

Early-life adversity exposure produced more pronounced cellular changes than adversity experienced later in life, and female cases displayed stronger transcriptomic associations than males with adversity exposure.

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Natalie Matosin @nataliematosin.bsky.social · 12d

In individuals with psychiatric disorders and high adversity exposure, we identified distinct alterations to glutamate-related synaptic functions, supported by histological quantification of >20,000 astrocytes.

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Natalie Matosin @nataliematosin.bsky.social · 12d

We probed the diversity of ∼145,000 total human cortical astrocytes with single nucleus and spatial transcriptomics, and showed that human astrocytes comprise a molecularly and anatomically diverse cell population.

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Natalie Matosin @nataliematosin.bsky.social · 12d

Latest lab preprint! Astrocytes are a brain cell type vulnerable to the effects of stress and the development of psychiatric-like phenotypes in animals, yet how this translates to humans is unclear... so we dived in:

www.biorxiv.org/content/10.1...

Astrocytic glutamate regulation is shaped by adversity and glucocorticoid signalling

Astrocytes are a brain cell type vulnerable to the effects of stress and the development of psychiatric-like phenotypes in animals, yet how this translates to humans is unclear. Here, we probed the di...

www.biorxiv.org

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Natalie Matosin @nataliematosin.bsky.social · Aug 17

Wonderful visits, highlighted the need for face-to-face interactions. Cant wait for all our upcoming collabs 🙌 thanks for carving time out to come see us @drcricru.bsky.social @nikosdaskalakis.bsky.social @rcbagot.bsky.social

MINDS Lab USYD @mindslab.bsky.social · Aug 17

Grateful to host @drcricru.bsky.social, @nikosdaskalakis.bsky.social & @rcbagot.bsky.social at USYD over the last few months. Your talks highlighted the importance of our field and understanding stress in mental illness. Lots of new ideas for future collaborations. Thanks for coming!

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Natalie Matosin @nataliematosin.bsky.social · Aug 12

The newspaper did say they reached out to you! I’m looking forward to reading your book, love your work 🩵

Natalie Matosin @nataliematosin.bsky.social · Aug 11

Microdosing delight to combat stress; interesting concept, backed by neuroscience. Was a pleasure to comment on the very excellent work of @drrachelbarr.bsky.social ‬on how the experience of delight can tune down our stress response. @brainandmindcentre.bsky.social www.smh.com.au/lifestyle/he...

As we stress more than ever, is it time to ‘microdose delight’?

Our brains are not built to handle the daily threats modern humans face. But there’s a trick that may help them.

www.smh.com.au

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Natalie Matosin @nataliematosin.bsky.social · Aug 5

BIOLOGICAL STRESS

Hannah Thomasy @hannahthomasy.bsky.social · Aug 5

It’s wild that “species” is one of the most fundamental concepts in biology but we can’t really define it & there are LOTS of organisms that experts disagree about. Are there other concepts in science that seem simple from the outside but are actually complicated? Plz dish the drama in your field🧪🧬🦠

What defines a species? Inside the fierce debate that's rocking biology to its core

The question of what defines a species has vexed scientists across the ages, particularly in conservation, where decisions require a firm understanding of biodiversity.

www.livescience.com

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Reposted by Natalie Matosin

JAMA @jama.com · Aug 2

US children's health has worsened from 2007 to 2023 across various indicators, including mortality, chronic conditions, and mental health.

ja.ma/4lZnRxG #MedSky #PedSky

Figure 1. All-Cause Mortality Rates per 100 000 in the US vs OECD18 for <1-Year-Old Infants and 1- to 19-Year-Old Individuals, 2007-2022

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Reposted by Natalie Matosin

Joar Øveraas Halvorsen @joarhalvorsen.bsky.social · Aug 2

This title!

“What happens to children’s mental health when we treat their parent’s depression? We have no idea. An empty systematic review.”

www.cambridge.org/core/journal...

What happens to children’s mental health when we treat their parent’s depression? We have no idea. An empty systematic review | Behavioural and Cognitive Psychotherapy | Cambridge Core

What happens to children’s mental health when we treat their parent’s depression? We have no idea. An empty systematic review

www.cambridge.org

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Natalie Matosin @nataliematosin.bsky.social · Jul 16

Reminder that applications are due this week!

MINDS Lab USYD @mindslab.bsky.social · Jul 7

📢 Help us progress our research! Opportunity to join our team.

We are recruiting a Research Assistant/Lab Manager. If you have experience in supporting a lab and tissue handling experience, we'd love to hear from you

Closes Sunday 20 July 2025 11:59

usyd.wd105.myworkdayjobs.com/USYD_EXTERNA...

Research Officer

Full time fixed term contract for one year Exciting opportunity to drive research to better understand how stress raises risk for mental illness using a broad range of cutting-edge techniques and anal...

usyd.wd105.myworkdayjobs.com

Natalie Matosin @nataliematosin.bsky.social · Jul 7

Note that we are only looking for candidates already in Australia for this position as we need to get started ASAP!

Natalie Matosin @nataliematosin.bsky.social · Jul 7

Looking for the next member of our team to support our ongoing projects. Check out the PD and if you think you're a fit, please apply!

MINDS Lab USYD @mindslab.bsky.social · Jul 7

📢 Help us progress our research! Opportunity to join our team.

We are recruiting a Research Assistant/Lab Manager. If you have experience in supporting a lab and tissue handling experience, we'd love to hear from you

Closes Sunday 20 July 2025 11:59

usyd.wd105.myworkdayjobs.com/USYD_EXTERNA...

Research Officer

Full time fixed term contract for one year Exciting opportunity to drive research to better understand how stress raises risk for mental illness using a broad range of cutting-edge techniques and anal...

usyd.wd105.myworkdayjobs.com

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Natalie Matosin @nataliematosin.bsky.social · Jun 27

This is important

Olivia Guest · Ολίβια Γκεστ @olivia.science · Jun 27

Hello & HAPPY FRIDAY, as promised an open letter by my lovely colleagues and myself. Everybody, feel free to sign this even if you are not NL-based and ‼️ share ‼️ (anonymous signature is poss):

Open Letter: Stop the Uncritical Adoption of AI Technologies in Academia

openletter.earth/open-letter-...

Open Letter: Stop the Uncritical Adoption of AI Technologies in Academia

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Natalie Matosin @nataliematosin.bsky.social · Jun 23

A pleasure to spend the last week with @drcricru.bsky.social - to share her fascinating work on brain/placenta with my colleagues at @Sydney_Uni and introduce her to our beautiful city + home. So lucky to have had extended time to bounce ideas and ponder life with this brilliant mind✨

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Reposted by Natalie Matosin

MINDS Lab USYD @mindslab.bsky.social · Jun 10

Check out our new paper led by the MINDS Lab original mass spec baddie @katrinazedmond.bsky.social 💃

Natalie Matosin @nataliematosin.bsky.social · Jun 10

🚨 NEW PAPER 🚨
Thrilled to share our latest work in "The Neurobiology of Stress" where we highlight the intricate roles of neuropeptides and neurosteroids in psychiatric disorders, & how new technologies can answer old questions about these important signallers. sciencedirect.com/science/arti...

Expanding our understanding of (mal)adapted stress physiology in psychiatric disorders: achieving single-cell characterisation of steroids and neuropeptides

Steroid hormones and neurosteroids (collectively neuroactive steroids), alongside neuropeptides, are key modulators of the central nervous system. The…

sciencedirect.com

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Natalie Matosin @nataliematosin.bsky.social · Jun 10

Fabulous work led by our PhD student @katrinazedmond.bsky.social - and congrats on your first first-author paper, Katrina!

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Natalie Matosin @nataliematosin.bsky.social · Jun 10

🚨 NEW PAPER 🚨
Thrilled to share our latest work in "The Neurobiology of Stress" where we highlight the intricate roles of neuropeptides and neurosteroids in psychiatric disorders, & how new technologies can answer old questions about these important signallers. sciencedirect.com/science/arti...

Expanding our understanding of (mal)adapted stress physiology in psychiatric disorders: achieving single-cell characterisation of steroids and neuropeptides

Steroid hormones and neurosteroids (collectively neuroactive steroids), alongside neuropeptides, are key modulators of the central nervous system. The…

sciencedirect.com

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