Nessim Louafi
@nesslfy.bsky.social
PhD Student in Luca Giorgetti's Lab (@lucagiorgetti.bsky.social) - Genome architecture - Microscopy - Image analysis - Biophysics
Reposted by Nessim Louafi
📢 Please help spread the word: We’re hiring a Head of Student & Postdoc Affairs to coordinate our international PhD program, provide guidance & career counseling, lead training programs, collaborate on EDI initiatives, and manage alumni relations. Apply at www.fmi.ch/education-ca...
December 4, 2025 at 7:23 AM
📢 Please help spread the word: We’re hiring a Head of Student & Postdoc Affairs to coordinate our international PhD program, provide guidance & career counseling, lead training programs, collaborate on EDI initiatives, and manage alumni relations. Apply at www.fmi.ch/education-ca...
Reposted by Nessim Louafi
Here is a copy of last year's Twitter thread explaining our preprint - jump to (21) for the new stuff 👀
Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function
now revised and journal accepted at www.science.org/doi/10.1126/...
🧵👇
Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function
now revised and journal accepted at www.science.org/doi/10.1126/...
🧵👇
November 27, 2025 at 9:59 PM
Here is a copy of last year's Twitter thread explaining our preprint - jump to (21) for the new stuff 👀
Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function
now revised and journal accepted at www.science.org/doi/10.1126/...
🧵👇
Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function
now revised and journal accepted at www.science.org/doi/10.1126/...
🧵👇
Reposted by Nessim Louafi
We are hiring a 2-year postdoctoral researcher to join our Membrane Biophysics team at the CBS in Montpellier. Join us to reinvent Atomic Force Microscopy to image the most common interface on our planet: the surface of water @membranesbiophy.bsky.social @cbsmontpellier.bsky.social
November 25, 2025 at 1:04 PM
We are hiring a 2-year postdoctoral researcher to join our Membrane Biophysics team at the CBS in Montpellier. Join us to reinvent Atomic Force Microscopy to image the most common interface on our planet: the surface of water @membranesbiophy.bsky.social @cbsmontpellier.bsky.social
Reposted by Nessim Louafi
In two weeks, our #qbio #Master students learned to build, from drawing to full realization, their own : confocal FCS, TIRF microscope, and optical tweezers setup ! This is hand-on #microscopy !
Interested ? Join the qbio master next year at the Montpellier University !
qbio.umontpellier.fr
Interested ? Join the qbio master next year at the Montpellier University !
qbio.umontpellier.fr
November 8, 2025 at 11:45 AM
In two weeks, our #qbio #Master students learned to build, from drawing to full realization, their own : confocal FCS, TIRF microscope, and optical tweezers setup ! This is hand-on #microscopy !
Interested ? Join the qbio master next year at the Montpellier University !
qbio.umontpellier.fr
Interested ? Join the qbio master next year at the Montpellier University !
qbio.umontpellier.fr
Reposted by Nessim Louafi
Postdoctoral position in the team of Alessandro Barducci in the CBS, focusing on multiscale simulations of RNA-driven condensates, with applications in synthetic biology.
More information :
www.cbs.cnrs.fr/images/jobs/...
The position is expected to start in early 2026, with some flexibility.
More information :
www.cbs.cnrs.fr/images/jobs/...
The position is expected to start in early 2026, with some flexibility.
November 5, 2025 at 5:43 PM
Postdoctoral position in the team of Alessandro Barducci in the CBS, focusing on multiscale simulations of RNA-driven condensates, with applications in synthetic biology.
More information :
www.cbs.cnrs.fr/images/jobs/...
The position is expected to start in early 2026, with some flexibility.
More information :
www.cbs.cnrs.fr/images/jobs/...
The position is expected to start in early 2026, with some flexibility.
Reposted by Nessim Louafi
📢 Spread the word: Applications are now open for our #PhD and #MDPhD programs! Become part of Basel, Europe’s #LifeScience hub, and grow in a dynamic, international, and supportive community. Apply by Nov 15: www.fmi.ch/education-ca...
September 26, 2025 at 7:19 AM
📢 Spread the word: Applications are now open for our #PhD and #MDPhD programs! Become part of Basel, Europe’s #LifeScience hub, and grow in a dynamic, international, and supportive community. Apply by Nov 15: www.fmi.ch/education-ca...
Very excited to share my PhD project! With @mattiaubertini.bsky.social in @lucagiorgetti.bsky.social we combined polymer simulation and super resolution live-cell imaging to study the dynamics of encounter of distant loci in the genome.
Really excited to share our latest work led by @mattiaubertini.bsky.social and @nesslfy.bsky.social: we report that cohesin loop extrusion creates rare but long-lived encounters between genomic sequences which underlie efficient enhancer-promoter communication.
www.biorxiv.org/content/10.1...
A🧵👇
www.biorxiv.org/content/10.1...
A🧵👇
September 25, 2025 at 7:04 AM
Very excited to share my PhD project! With @mattiaubertini.bsky.social in @lucagiorgetti.bsky.social we combined polymer simulation and super resolution live-cell imaging to study the dynamics of encounter of distant loci in the genome.
Reposted by Nessim Louafi
📣The Turco group is seeking a computational biologist to analyze large omics datasets. Work on cutting-edge 3D organoid models of the human placenta and be embedded in our Computational Biology Platform (part of @sib.swiss). Apply here: www.fmi.ch/education-ca...
September 12, 2025 at 7:02 AM
📣The Turco group is seeking a computational biologist to analyze large omics datasets. Work on cutting-edge 3D organoid models of the human placenta and be embedded in our Computational Biology Platform (part of @sib.swiss). Apply here: www.fmi.ch/education-ca...
Reposted by Nessim Louafi
I am excited to announce that we are looking for a Lab Manager @fmiscience.bsky.social in Basel. If you want to be part of a growing team investigating development and tissue formation, and are enthusiastic about helping set up a new lab, please check out the role:
www.fmi.ch/education-ca...
www.fmi.ch/education-ca...
September 14, 2025 at 11:46 AM
I am excited to announce that we are looking for a Lab Manager @fmiscience.bsky.social in Basel. If you want to be part of a growing team investigating development and tissue formation, and are enthusiastic about helping set up a new lab, please check out the role:
www.fmi.ch/education-ca...
www.fmi.ch/education-ca...
Reposted by Nessim Louafi
🚨 We're hiring, please share! The FMI seeks a tenure-track Group Leader (Assistant Prof) in Structural Biology 🔬
Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...
Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...
September 8, 2025 at 8:15 AM
🚨 We're hiring, please share! The FMI seeks a tenure-track Group Leader (Assistant Prof) in Structural Biology 🔬
Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...
Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...
Reposted by Nessim Louafi
A new preprint from our lab with @zelechowski.bsky.social & @georgkeller.bsky.social !
Using wireless EEG + VR, we recorded visuomotor mismatch responses in freely moving humans.
Huge thanks to all participants, Keller Lab members and FMI facilities!
Read more: www.biorxiv.org/content/10.1...
Using wireless EEG + VR, we recorded visuomotor mismatch responses in freely moving humans.
Huge thanks to all participants, Keller Lab members and FMI facilities!
Read more: www.biorxiv.org/content/10.1...
August 19, 2025 at 1:39 PM
A new preprint from our lab with @zelechowski.bsky.social & @georgkeller.bsky.social !
Using wireless EEG + VR, we recorded visuomotor mismatch responses in freely moving humans.
Huge thanks to all participants, Keller Lab members and FMI facilities!
Read more: www.biorxiv.org/content/10.1...
Using wireless EEG + VR, we recorded visuomotor mismatch responses in freely moving humans.
Huge thanks to all participants, Keller Lab members and FMI facilities!
Read more: www.biorxiv.org/content/10.1...
Reposted by Nessim Louafi
New preprint with @gfudenberg.bsky.social
We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding.
This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇
www.biorxiv.org/content/10.1...
We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding.
This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇
www.biorxiv.org/content/10.1...
NIPBL dosage shapes genome folding by tuning the rate of cohesin loop extrusion
Cohesin loop extrusion is a major driver of chromosome folding, but how its dynamics are controlled to shape the genome remains elusive. Here we disentangle the contributions of the cohesin cofactors ...
www.biorxiv.org
August 16, 2025 at 3:03 AM
New preprint with @gfudenberg.bsky.social
We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding.
This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇
www.biorxiv.org/content/10.1...
We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding.
This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇
www.biorxiv.org/content/10.1...
Reposted by Nessim Louafi
How can we quantify cell potency from scRNAseq data?
In our latest preprint, we show that intrinsic dimensionality (ID) tracks potency in single cells across reprogramming datasets, and we provide IDEAS, a Python toolkit for ID-based potency analysis: www.biorxiv.org/content/10.1...
In our latest preprint, we show that intrinsic dimensionality (ID) tracks potency in single cells across reprogramming datasets, and we provide IDEAS, a Python toolkit for ID-based potency analysis: www.biorxiv.org/content/10.1...
Intrinsic dimensionality of single-cell transcriptomic data reveals potency landscapes during cell reprogramming
Cell potency, the ability of a cell to generate other cell types, is a fundamental property that drives development, regeneration, and reprogramming. Recent computational advances have en- abled estim...
www.biorxiv.org
July 25, 2025 at 7:46 PM
How can we quantify cell potency from scRNAseq data?
In our latest preprint, we show that intrinsic dimensionality (ID) tracks potency in single cells across reprogramming datasets, and we provide IDEAS, a Python toolkit for ID-based potency analysis: www.biorxiv.org/content/10.1...
In our latest preprint, we show that intrinsic dimensionality (ID) tracks potency in single cells across reprogramming datasets, and we provide IDEAS, a Python toolkit for ID-based potency analysis: www.biorxiv.org/content/10.1...
Reposted by Nessim Louafi
We found a new asymmetry in the large-scale chromosome structure: sister chromatids are systematically shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! The work was led by Flavia Corsi, in close collaboration with the Daniel Gerlich lab.
www.biorxiv.org/content/10.1...
1/
www.biorxiv.org/content/10.1...
1/
July 15, 2025 at 8:11 AM
We found a new asymmetry in the large-scale chromosome structure: sister chromatids are systematically shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! The work was led by Flavia Corsi, in close collaboration with the Daniel Gerlich lab.
www.biorxiv.org/content/10.1...
1/
www.biorxiv.org/content/10.1...
1/
Reposted by Nessim Louafi
We are looking for a research assistant to join our lab and support ongoing projects with genome engineering in mouse embryonic stem cells! Please get in touch if you are interested.
www.fmi.ch/education-ca...
www.fmi.ch/education-ca...
Friedrich Miescher Institute, open position
Friedrich Miescher Institute, open position
www.fmi.ch
June 26, 2025 at 3:04 PM
We are looking for a research assistant to join our lab and support ongoing projects with genome engineering in mouse embryonic stem cells! Please get in touch if you are interested.
www.fmi.ch/education-ca...
www.fmi.ch/education-ca...
Reposted by Nessim Louafi
Come and work with us!
Super exciting and relevant projects!
Become an #AI pro and do something positive for the 🌍!
👩🎓 🧑🎓
If you know someone who might be interested… please repost and/or forward this! 🙏
Super exciting and relevant projects!
Become an #AI pro and do something positive for the 🌍!
👩🎓 🧑🎓
If you know someone who might be interested… please repost and/or forward this! 🙏
🚀 Fully-funded #PhD opportunity in Computational Biology with our @florianjug.bsky.social Group through Politecnico of Milan DADS programme! Co-supervision by Francesca Ieva.
🧬 Use #AI to decode complex biological data across scales.
Apply by 9 July 👉 humantechnopole.it/en/news/1-fu...
🧬 Use #AI to decode complex biological data across scales.
Apply by 9 July 👉 humantechnopole.it/en/news/1-fu...
June 9, 2025 at 7:51 AM
Come and work with us!
Super exciting and relevant projects!
Become an #AI pro and do something positive for the 🌍!
👩🎓 🧑🎓
If you know someone who might be interested… please repost and/or forward this! 🙏
Super exciting and relevant projects!
Become an #AI pro and do something positive for the 🌍!
👩🎓 🧑🎓
If you know someone who might be interested… please repost and/or forward this! 🙏
Reposted by Nessim Louafi
Spotiflow, our deep learning based spot detection method for microscopy, is now published in @natmethods.nature.com!
Since the pre-print, we have added many features, notably native 3D detection!
@maweigert.bsky.social @gioelelamanno.bsky.social @epfl-brainmind.bsky.social
Paper: rdcu.be/epIB7
(1/N)
Since the pre-print, we have added many features, notably native 3D detection!
@maweigert.bsky.social @gioelelamanno.bsky.social @epfl-brainmind.bsky.social
Paper: rdcu.be/epIB7
(1/N)
Spotiflow: accurate and efficient spot detection for fluorescence microscopy with deep stereographic flow regression
Nature Methods - Spotiflow uses deep learning for subpixel-accurate spot detection in diverse 2D and 3D images. The improved accuracy offered by Spotiflow enables improved biological insights in...
rdcu.be
June 6, 2025 at 6:58 PM
Spotiflow, our deep learning based spot detection method for microscopy, is now published in @natmethods.nature.com!
Since the pre-print, we have added many features, notably native 3D detection!
@maweigert.bsky.social @gioelelamanno.bsky.social @epfl-brainmind.bsky.social
Paper: rdcu.be/epIB7
(1/N)
Since the pre-print, we have added many features, notably native 3D detection!
@maweigert.bsky.social @gioelelamanno.bsky.social @epfl-brainmind.bsky.social
Paper: rdcu.be/epIB7
(1/N)
Reposted by Nessim Louafi
(1/n) Thread @matteomazzocca.bsky.social @domenicnarducci.bsky.social Simon Grosse-Holz @jessematthias.bsky.social preprint
Q: how does chromatin move?
Using MINFLUX, SPT & SRLCI, we track chromatin dynamics across 7 orders of magnitude in time to provide answers www.biorxiv.org/content/10.1...
Q: how does chromatin move?
Using MINFLUX, SPT & SRLCI, we track chromatin dynamics across 7 orders of magnitude in time to provide answers www.biorxiv.org/content/10.1...
May 15, 2025 at 12:37 PM
(1/n) Thread @matteomazzocca.bsky.social @domenicnarducci.bsky.social Simon Grosse-Holz @jessematthias.bsky.social preprint
Q: how does chromatin move?
Using MINFLUX, SPT & SRLCI, we track chromatin dynamics across 7 orders of magnitude in time to provide answers www.biorxiv.org/content/10.1...
Q: how does chromatin move?
Using MINFLUX, SPT & SRLCI, we track chromatin dynamics across 7 orders of magnitude in time to provide answers www.biorxiv.org/content/10.1...
Reposted by Nessim Louafi
How can AI help you to analyze your microscopy images?
Find out at the "Machine Learning for Microscopy Image Analysis" course at the @mblscience.bsky.social in Woods Hole from Aug 22-Sep 6!
Applications are due 🚨 April 30 🚨
Read on for more! 👇
www.mbl.edu/education/ad...
Find out at the "Machine Learning for Microscopy Image Analysis" course at the @mblscience.bsky.social in Woods Hole from Aug 22-Sep 6!
Applications are due 🚨 April 30 🚨
Read on for more! 👇
www.mbl.edu/education/ad...
AI@MBL: Machine Learning for Microscopy Image Analysis | Marine Biological Laboratory
The goal of this course is to familiarize researchers in the life sciences with state-of-the-art deep learning techniques for microscopy image analysis and to introduce them to tools and frameworks th...
www.mbl.edu
April 18, 2025 at 6:48 PM
How can AI help you to analyze your microscopy images?
Find out at the "Machine Learning for Microscopy Image Analysis" course at the @mblscience.bsky.social in Woods Hole from Aug 22-Sep 6!
Applications are due 🚨 April 30 🚨
Read on for more! 👇
www.mbl.edu/education/ad...
Find out at the "Machine Learning for Microscopy Image Analysis" course at the @mblscience.bsky.social in Woods Hole from Aug 22-Sep 6!
Applications are due 🚨 April 30 🚨
Read on for more! 👇
www.mbl.edu/education/ad...
Reposted by Nessim Louafi
📢Please share: We're now accepting applications for our #PhD and #MDPhD programs!
🧬Join us in Basel, Europe's #LifeScience hub, and unleash your potential in a vibrant, international and supportive environment.
📅Apply by May 1 at www.fmi.ch/education-ca...
🧬Join us in Basel, Europe's #LifeScience hub, and unleash your potential in a vibrant, international and supportive environment.
📅Apply by May 1 at www.fmi.ch/education-ca...
February 18, 2025 at 1:29 PM
📢Please share: We're now accepting applications for our #PhD and #MDPhD programs!
🧬Join us in Basel, Europe's #LifeScience hub, and unleash your potential in a vibrant, international and supportive environment.
📅Apply by May 1 at www.fmi.ch/education-ca...
🧬Join us in Basel, Europe's #LifeScience hub, and unleash your potential in a vibrant, international and supportive environment.
📅Apply by May 1 at www.fmi.ch/education-ca...
Reposted by Nessim Louafi
Celebrating 10 years of our lab with a new preprint:
www.biorxiv.org/content/10.1...
How does enhancer location within a TAD control transcriptional bursts from a cognate promoter?
Experiments by Jana Tünnermann and modelling by Gregory Roth
www.biorxiv.org/content/10.1...
How does enhancer location within a TAD control transcriptional bursts from a cognate promoter?
Experiments by Jana Tünnermann and modelling by Gregory Roth
March 29, 2025 at 12:46 PM
Celebrating 10 years of our lab with a new preprint:
www.biorxiv.org/content/10.1...
How does enhancer location within a TAD control transcriptional bursts from a cognate promoter?
Experiments by Jana Tünnermann and modelling by Gregory Roth
www.biorxiv.org/content/10.1...
How does enhancer location within a TAD control transcriptional bursts from a cognate promoter?
Experiments by Jana Tünnermann and modelling by Gregory Roth
Still time to apply to this great program! (Objectively)
Join the qbio Master’s Program in Montpellier, France : Quantitative Biology: Molecular Mechanisms of Living Systems
Q&A Session on Monday, February 10!
This curriculum blends biology, physics, bioinformatics, and quantitative methods to tackle biological challenges.
qbio.umontpellier.fr
Q&A Session on Monday, February 10!
This curriculum blends biology, physics, bioinformatics, and quantitative methods to tackle biological challenges.
qbio.umontpellier.fr
qBio – Quantitative Biology Master Montpellier
At the crossroads of Biology, Physics, Chemistry and Informatics, qbio is the graduate program destined for students interested in studying Biology with a quantitative perspective founded on transdisc...
qbio.umontpellier.fr
March 8, 2025 at 11:32 AM
Still time to apply to this great program! (Objectively)
Reposted by Nessim Louafi
🚨Job alert: We're hiring a Data Scientist (Image Analysis) to join our Facility for Advanced Imaging & Microscopy. The facility provides cutting-edge light and electron microscopy, high-content screening, image analysis and spatial-transcriptomics services.
Apply at: www.fmi.ch/education-ca...
Apply at: www.fmi.ch/education-ca...
February 12, 2025 at 7:55 AM
🚨Job alert: We're hiring a Data Scientist (Image Analysis) to join our Facility for Advanced Imaging & Microscopy. The facility provides cutting-edge light and electron microscopy, high-content screening, image analysis and spatial-transcriptomics services.
Apply at: www.fmi.ch/education-ca...
Apply at: www.fmi.ch/education-ca...
Reposted by Nessim Louafi
📣 Please share: We’re hiring a tenure-track Group Leader in Multicellular Systems to explore the molecular and cellular mechanisms driving the formation, maintenance, or destabilization of tissues, organs and organisms. Apply at: www.fmi.ch/education-ca...
December 16, 2024 at 11:50 AM
📣 Please share: We’re hiring a tenure-track Group Leader in Multicellular Systems to explore the molecular and cellular mechanisms driving the formation, maintenance, or destabilization of tissues, organs and organisms. Apply at: www.fmi.ch/education-ca...
Reposted by Nessim Louafi
Incredible day for the lab with @mattiaubertini.bsky.social and Verena Mutzel both being awarded EMBO fellowships to pursue their postdoctoral projects! We're so proud of them and grateful to the EMBO community for supporting our science.
December 11, 2024 at 6:46 PM
Incredible day for the lab with @mattiaubertini.bsky.social and Verena Mutzel both being awarded EMBO fellowships to pursue their postdoctoral projects! We're so proud of them and grateful to the EMBO community for supporting our science.