SteffiK.
ngn-steffi.bsky.social
SteffiK.
@ngn-steffi.bsky.social
Seit 2021 an Post-Vac, Me/Cfs uvm erkrankt
😢
September 15, 2025 at 4:04 PM
Danke ☺️
July 30, 2025 at 1:06 PM
• Vildagliptin und Saxagliptin stellten durch PI-PLC-Hemmung die membrangebundene SMPDL3B wieder her, was auf eine neuartige therapeutische Strategie für ME hindeutet.

pubmed.ncbi.nlm.nih.gov/40624584/
SMPDL3B a novel biomarker and therapeutic target in myalgic encephalomyelitis - PubMed
SMPDL3B emerges as a key biomarker for ME severity and immune dysregulation, with its activity influenced by hormonal and PI-PLC regulation. The ability of vildagliptin and saxagliptin to preserve mem...
pubmed.ncbi.nlm.nih.gov
July 24, 2025 at 11:57 AM
• Geschlechtsspezifische Unterschiede wurden festgestellt, wobei weibliche ME-Patienten höhere Plasma-SMPDL3B-Spiegel aufwiesen, die durch Östrogen beeinflusst wurden.
SMPDL3B a novel biomarker and therapeutic target in myalgic encephalomyelitis - PubMed
SMPDL3B emerges as a key biomarker for ME severity and immune dysregulation, with its activity influenced by hormonal and PI-PLC regulation. The ability of vildagliptin and saxagliptin to preserve mem...
pubmed.ncbi.nlm.nih.gov
July 24, 2025 at 11:57 AM
• Es wurden auch eine erhöhte PLCXD1-Expression und erhöhte Plasmaspiegel von PI-PLC beobachtet, was auf eine verstärkte Spaltung von membrangebundenem SMPDL3B hindeutet.
SMPDL3B a novel biomarker and therapeutic target in myalgic encephalomyelitis - PubMed
SMPDL3B emerges as a key biomarker for ME severity and immune dysregulation, with its activity influenced by hormonal and PI-PLC regulation. The ability of vildagliptin and saxagliptin to preserve mem...
pubmed.ncbi.nlm.nih.gov
July 24, 2025 at 11:57 AM
• ME-Patienten zeigten erhöhte Plasma-SMPDL3B-Spiegel, die mit der Schwere der Symptome korrelierten, und reduzierten membrangebundene SMPDL3B-Spiegel in Monozyten.
SMPDL3B a novel biomarker and therapeutic target in myalgic encephalomyelitis - PubMed
SMPDL3B emerges as a key biomarker for ME severity and immune dysregulation, with its activity influenced by hormonal and PI-PLC regulation. The ability of vildagliptin and saxagliptin to preserve mem...
pubmed.ncbi.nlm.nih.gov
July 24, 2025 at 11:56 AM
🫂❤️
July 24, 2025 at 9:47 AM