Nicolas Malaquin, PhD
@nmalaquin.bsky.social
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Scientist at the CRCHUM-Institut du Cancer de Montréal. Senescence SASP and cancer
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Reposted by Nicolas Malaquin, PhD
LBI Trauma
@lbitrauma.bsky.social
· Dec 31
Guidelines for minimal information on cellular senescence experimentation in vivo
This primer introduces the “minimal information on cellular senescence experimentation in vivo” (MICSE) guidelines, which aim to address the challenges in identifying and characterizing senescent cells. It provides an overview of senescence markers in various systems and offers a practical toolset to enhance our understanding of cellular senescence in vivo.
www.cell.com
Reposted by Nicolas Malaquin, PhD
Nicolas Manel Lab
@manellab.bsky.social
· Jan 14
Chromosome mis-segregation triggers cell cycle arrest through a mechanosensitive nuclear envelope checkpoint - Nature Cell Biology
Hervé, Scelfo et al. show that chromosome mis-segregation induces mTORC2- and ATR-mediated p53 activation through a mechanosensitive checkpoint at the nuclear envelope triggered by altered heterochrom...
doi.org
Reposted by Nicolas Malaquin, PhD
Reposted by Nicolas Malaquin, PhD