ogatkk.bsky.social
Kosuke Ogata
@ogatkk.bsky.social
110 followers 250 following 1 posts
Assistant Professor at Kyoto University, Japan. Proteomics; Mass spectrometry; Protein phosphorylation; Protein structure. Seeking the analytical method to evaluate the protein structure and phosphorylation.
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ogatkk.bsky.social
Kosuke Ogata @ogatkk.bsky.social · May 13
We utilized protein kinases to probe substrate protein structures. The phosphate groups enabled selective extraction of labeled sites.
Detecting Protein Higher-Order Structural Changes Using Kinase as a Phospho-Labeler www.biorxiv.org/content/10.1...
Detecting Protein Higher-Order Structural Changes Using Kinase as a Phospho-Labeler
We developed an approach to detect protein conformational changes on a proteome-wide scale by labeling proteins with phosphate groups through in vitro kinase reactions. This structural proteomics appr...
www.biorxiv.org
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Reposted by Kosuke Ogata
mannlab.bsky.social
Mann Lab @mannlab.bsky.social · Feb 26
In our latest @Nature review with Tiannan Guo & Judith Steen, we explore how technological breakthroughs are revolutionizing MS-based proteomics: From enhanced sensitivity enabling single-cell analysis to high-throughput plasma proteomics & AI-based data interpretation
www.nature.com/articles/s41...
Mass-spectrometry-based proteomics: from single cells to clinical applications - Nature
This Review summarizes advances in mass-spectrometry-based proteomics and explores the potential applications of these technologies in the clinic.
www.nature.com
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Reposted by Kosuke Ogata
vadim-demichev.bsky.social
Vadim Demichev @vadim-demichev.bsky.social · Jan 29
DIA-NN 2.0 is released! We consider it the biggest step forward in the history of DIA-NN. On modern LC-MS almost all identifications are now peptidoform-confident, with major improvements e.g. for phospho. Some other cool things too: github.com/vdemichev/Di...
Release DIA-NN 2.0 · vdemichev/DiaNN
We are excited to announce DIA-NN 2.0, the most significant milestone in the history of DIA-NN development. Key Breakthroughs Proteoform Confidence mode: DIA-NN 2.0 solves the long-standing chall...
github.com
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Reposted by Kosuke Ogata
ajbrenes.com
Alejandro Brenes @ajbrenes.com · Nov 10
#teamMassSpec here is a starting pack in case you just moved over, or in case you've been absent for a while. This is #proteomics or #massspec related. The pack is not comprehensive but it's a start.

go.bsky.app/HH7kqEh
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Reposted by Kosuke Ogata
ajbrenes.com
Alejandro Brenes @ajbrenes.com · Nov 16
Here's a new list for early career researchers (=not had your own lab for ages) in proteomics.

Feel free to ask to be added or removed, I've tried to make a guess but could've got it wrong.

I think it's good to also have an ECR network.

#teamMassSpec

go.bsky.app/Dp8PHX1
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