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olechsylte.bsky.social
Ole Christian Sylte
@olechsylte.bsky.social
130 followers 150 following 15 posts
Neuroscientist, postdoc in Stephenson-Jones lab at Sainsbury Wellcome Centre, UCL
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olechsylte.bsky.social
Ole Christian Sylte @olechsylte.bsky.social · Feb 5
Stable maps from drifting neurons: CA1 solves the "representational drift paradox" through coordinated population dynamics.

New preprint w/ @antjekilias.bsky.social , Marlene Bartos and @jf-sauer.bsky.social showing that representational drift isn’t random—it’s structured to preserve information🧵👇
Coordinated representational drift supports stable place coding in hippocampal CA1
The phenomenon of representational drift (i.e., changing neuronal tuning during repeated exposure to the same stimuli), is a fundamental paradox in neuroscience that raises the question how stable beh...
www.biorxiv.org
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Reposted by Ole Christian Sylte
gatsbyucl.bsky.social
Gatsby Computational Neuroscience Unit @gatsbyucl.bsky.social · 13d
🙋Are you interested in bridging theory & experiments?

Applications are now open for 2026 entry to the Gatsby Unit & SWC joint PhD programme.

Join us and be part of a vibrant research community!

💰 Fully-funded 4-year programme
ℹ️ www.ucl.ac.uk/life-science...

@sainsburywellcome.bsky.social
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Reposted by Ole Christian Sylte
sainsburywellcome.bsky.social
Sainsbury Wellcome Centre @sainsburywellcome.bsky.social · 15d
Applications are now open for the SWC Systems Neuroscience PhD Programme.

Join us in London!

🧠 World-class neuroscience training
💰 Fully-funded 4-year programme
🖥️ Close links to @gatsbyucl.bsky.social

Apply by 3 Nov: www.sainsburywellcome.org/web/content/...
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Reposted by Ole Christian Sylte
eelkesnoeren.bsky.social
Eelke Snoeren @eelkesnoeren.bsky.social · Aug 14
🚨New paper alert! We studied the long-term consequences of SSRI use during pregnancy on the offspring in rats in a seminatural environment. We found that perinatal FLX exposure significantly increases sexual behavior in adult male rats.
@uitnorgesarktiske.bsky.social
#neuroscience #neuroskyence
Perinatal fluoxetine exposure increases male rat sexual behavior
Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed to pregnant women due to their efficacy and safety profile, leading to potenti…
www.sciencedirect.com
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Reposted by Ole Christian Sylte
j-b-eppler.bsky.social
Jens-Bastian Eppler @j-b-eppler.bsky.social · Aug 4
And for me the big question is: What about representational drift? 😄

Manifolds can be mapped, but individual neuronal responses change. That’s neat, but how does it make sense?

How can perception stay stable if the neurons keep changing?
I’m sure manifolds will help us understand that too…

🧠🧪
3/3
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Reposted by Ole Christian Sylte
eelkesnoeren.bsky.social
Eelke Snoeren @eelkesnoeren.bsky.social · Jul 7
🚨 New Article Alert! 🚨
Our latest research reveals how long-term consumption of a cafeteria (CAF) diet impacts the ventral tegmental area in rats. 🍔🍟🍩#Neuroskyence @uitnorgesarktiske.bsky.social www.sciencedirect.com/science/arti...
Behavioral and neural alterations of the ventral tegmental area by exposure to junk food in rats
The brain reward system is essential for regulating appetitive and consummatory behaviors in response to various incentive stimuli. Junk food, charact…
www.sciencedirect.com
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Reposted by Ole Christian Sylte
eelkesnoeren.bsky.social
Eelke Snoeren @eelkesnoeren.bsky.social · May 31
New preprint alert! Perinatal fluoxetine exposure increases male rat sexual behavior. @uitnorgesarktiske.bsky.social #neuroscience #neuroskyence
biorxiv-neursci.bsky.social
bioRxiv Neuroscience @biorxiv-neursci.bsky.social · May 29
Perinatal fluoxetine exposure increases male rat sexual behavior https://www.biorxiv.org/content/10.1101/2025.05.26.656113v1
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Reposted by Ole Christian Sylte
thetransmitter.bsky.social
The Transmitter @thetransmitter.bsky.social · Jun 11
A non-value-based system in the brain automates decision-making and frees up cognitive resources for other tasks, a new study in mice suggests.

By Holly Barker

#neuroskyence

www.thetransmitter.org/neurobiology...
Dopamine neurons signal default behavior to reinforce habits
Movement-sensing neurons in the striatum influence a mouse’s choice of action by favoring routine behaviors.
www.thetransmitter.org
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Reposted by Ole Christian Sylte
ute-fr.bsky.social
Ute Häussler @ute-fr.bsky.social · May 20
A new paper from the group is online: we show that longterm low-frequency stimulation alleviates seizures beyond stimulation periods and reverses epilepsy-associated synaptic alterations. #TrEPILab

www.sciencedirect.com/science/arti...
Long-term hippocampal low-frequency stimulation alleviates focal seizures, memory deficits and synaptic pathology in epileptic mice
Mesial temporal lobe epilepsy (MTLE) is a prevalent form of focal epilepsy characterized by seizures originating from the hippocampus and adjacent reg…
www.sciencedirect.com
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Reposted by Ole Christian Sylte
antjekilias.bsky.social
Antje Kilias @antjekilias.bsky.social · May 18
Looking forward to an exciting Spring Hippocampal Research Conference in Verona with @mbartos.bsky.social @olechsylte.bsky.social @federicotorelli.bsky.social and @ute-fr.bsky.social
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Reposted by Ole Christian Sylte
hugospiers.bsky.social
Hugo Spiers @hugospiers.bsky.social · May 15
Impressive study in @nature from my colleague Marcus Stephenson-Jones at UCL in the @sainsburywellcome.bsky.social

www.nature.com/articles/s41...
Dopaminergic action prediction errors serve as a value-free teaching signal - Nature
Dopaminergic action prediction error signals are used by mice as a value-free teaching signal to reinforce stable sound–action associations in the tail of the striatum.
www.nature.com
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Reposted by Ole Christian Sylte
sainsburywellcome.bsky.social
Sainsbury Wellcome Centre @sainsburywellcome.bsky.social · May 14
Read the full paper ‘Dopaminergic action prediction errors serve as a value-free teaching signal’ in @natureportfolio.nature.com

@gatsbyucl.bsky.social @imperialcollegeldn.bsky.social

www.nature.com/articles/s41...
Dopaminergic action prediction errors serve as a value-free teaching signal - Nature
Dopaminergic action prediction error signals are used by mice as a value-free teaching signal to reinforce stable sound–action associations in the tail of the striatum.
www.nature.com
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Reposted by Ole Christian Sylte
in-code.bsky.social
in-code.bsky.social @in-code.bsky.social · Apr 30
Congrats to Aurore Gazala for winning the Eve Marder Best Paper Prize for “Subfield-specific interneuron circuits govern the hippocampal response to novelty in male mice” (Nat Comm, 2024) - awarded in person by Eve Marder at the IN-CODE retreat in Potsdam! @acazala.bsky.social #interneurons
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Reposted by Ole Christian Sylte
eelkesnoeren.bsky.social
Eelke Snoeren @eelkesnoeren.bsky.social · Apr 25
Play the "IBNS 2025 Reindeer Games Contest"! Share one of the reindeer adds on social media and get the most likes! @ibnsconnect.bsky.social

1st prize - $100 Gift Card or $200 off IBNS Registration
2nd prize - Free one year IBNS regular membership or two years Student/Postdoc membership
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olechsylte.bsky.social
Ole Christian Sylte @olechsylte.bsky.social · Apr 25
Don't miss your last chance to attend IBNS in Tromsø!
eelkesnoeren.bsky.social
Eelke Snoeren @eelkesnoeren.bsky.social · Apr 25
What about visiting a neuroscience conference in Europe this year? There is still time to register for IBNS in Tromsø (June 24th-29th 2025)! Please like and share! For more information: www.ibnsconnect.org/annual-meeting @ibnsconnect.bsky.social #neuroskyence
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olechsylte.bsky.social
Ole Christian Sylte @olechsylte.bsky.social · Apr 17
Really amazing!
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acazala.bsky.social
Aurore Cazala @acazala.bsky.social · Apr 17
🔬🤝🎨
Drawing over my 2photon recordings of axons in the dentate gyrus for our last picture contest ✨️
Mouse watching its axons
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Reposted by Ole Christian Sylte
mbartos.bsky.social
Marlene Bartos @mbartos.bsky.social · Mar 12
Check our new manuscript on ‚Coordinated representational drift supports stable place coding in the hippocampal CA1’
by Ole Sylte, Antje Kilias, Marlene Bartos and Jonas Sauer.

www.biorxiv.org/content/10.1...
Coordinated representational drift supports stable place coding in hippocampal CA1
The phenomenon of representational drift (i.e., changing neuronal tuning during repeated exposure to the same stimuli), is a fundamental paradox in neuroscience that raises the question how stable beh...
www.biorxiv.org
5 13
Reposted by Ole Christian Sylte
jf-sauer.bsky.social
Jonas Sauer @jf-sauer.bsky.social · Mar 11
New paper out! We found functional neuron classes in the mPFC with different spatial tuning properties (generalised vs. trajectory-specific) and distinct contribution to the encoding of task space. Great job by the first author Hannah!
www.cell.com/cell-reports...
Conjoint generalized and trajectory-specific coding of task structure by prefrontal neurons
Neurons in the medial prefrontal cortex (mPFC) show spatially modulated activities. Muysers et al. show that mPFC neurons fall into distinct functional classes that differ in terms of their spatial tu...
www.cell.com
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Reposted by Ole Christian Sylte
lmprida.bsky.social
Liset M. de la Prida @lmprida.bsky.social · Feb 26
New from the lab!! 👉🏼 authors.elsevier.com/a/1kgT43BtfH... 📝 @cellpress.bsky.social We discovered that genetically-defined neuron types in the hippocampus form unique manifolds! Dual color imaging, chemogenetics and topological analysis all at once! With Juan Gallego @juangallego.bsky.social
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Reposted by Ole Christian Sylte
acazala.bsky.social
Aurore Cazala @acazala.bsky.social · Feb 23
Slow life as a scientist
Drawing of a researcher performing analysis at his desk
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annduan.bsky.social
Chunyu Ann Duan @annduan.bsky.social · Feb 16
First preprint from our lab! An @jerlich.bsky.social collaboration

We developed novel frameworks to study multi-agent decisions in mice.

Mice flexibly shift their decision preference under social competition, by integrating real-time self and opponent information!

www.biorxiv.org/content/10.1...
Mice dynamically adapt to opponents in competitive multi-player games
Competing for resources in dynamic social environments is fundamental for survival, and requires continuous monitoring of both 'self' and 'others' to guide effective choices. Yet our understanding of ...
www.biorxiv.org
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olechsylte.bsky.social
Ole Christian Sylte @olechsylte.bsky.social · Feb 10
Don't miss the chance to present at the world's northernmost university city while catching the midnight sun 👇
ibnsconnect.bsky.social
International Behavioral Neuroscience Society @ibnsconnect.bsky.social · Feb 7
🚨 Reminder 🚨

📅 Submit your abstract by February 21, 2025!

Don’t miss your chance to be part of IBNS 2025 in Tromso, Norway!

👉More Details>> iibnsconnect.org/meetings
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olechsylte.bsky.social
Ole Christian Sylte @olechsylte.bsky.social · Feb 5
Huge thanks to co-first author @antjekilias.bsky.social for impressive experimental work, and to Marlene Bartos and @jf-sauer.bsky.social for their supervision!
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olechsylte.bsky.social
Ole Christian Sylte @olechsylte.bsky.social · Feb 5
How does this help downstream neurons?

If drift is coordinated (preserving geometry), downstream neurons can compensate and read stable spatial maps. But if drift distorts the geometry, a downstream network fails under noise.
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olechsylte.bsky.social
Ole Christian Sylte @olechsylte.bsky.social · Feb 5
How can the geometry be stable while individual neurons drift?

It turns out the entire population activity is gradually rotating and translating in neural state space. These two transformations can accurately account for the observed drift.
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