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Jonas Sauer @jf-sauer.bsky.social · Jun 2

Fantastic symposium on circuit function last week here at CIPMM. Thanks to our guests Kristina Lippmann, Magdalene Schlesiger, Fiona Muellner and @juliaveit.bsky.social for sharing their latest on synaptic function, interneuron & pyramidal cell networks and long-range communication.

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Reposted by Jonas Sauer

Torfi Sigurdsson @torfisigurdsson.bsky.social · Apr 24

See below for the latest results from the lab! Led by @susannebabl.bsky.social with support from @dfg.de and @for5159.bsky.social

Susanne Babl @susannebabl.bsky.social · Apr 24

The last part of my PhD with @torfisigurdsson.bsky.social is now published in @plosbiology.org

journals.plos.org/plosbiology/...

We looked at the interaction of the hippocampus and prefrontal cortex during spatial working memory when mice were navigating a T-maze, using ephys and optogenetics 🧠🐭

The dorsal and ventral hippocampus contribute differentially to spatial working memory and spatial coding in the prefrontal cortex

The hippocampus and prefrontal cortex interact to support spatial working memory, but are the dorsal and ventral hippocampus functionally redundant in this context? This study shows that both hippocam...

journals.plos.org

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Reposted by Jonas Sauer

Ilka Diester @ilka-diester.bsky.social · Apr 10

Engaging poster session at the IN-Code retreat. Thanks to our SAB members and all researchers of the CRC for their interest! All students did a great job presenting their projects. @mbartos.bsky.social @uni-freiburg.de @biologyunifreiburg.bsky.social

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Jonas Sauer @jf-sauer.bsky.social · Mar 11

New paper out! We found functional neuron classes in the mPFC with different spatial tuning properties (generalised vs. trajectory-specific) and distinct contribution to the encoding of task space. Great job by the first author Hannah!
www.cell.com/cell-reports...

Conjoint generalized and trajectory-specific coding of task structure by prefrontal neurons

Neurons in the medial prefrontal cortex (mPFC) show spatially modulated activities. Muysers et al. show that mPFC neurons fall into distinct functional classes that differ in terms of their spatial tu...

www.cell.com

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Jonas Sauer @jf-sauer.bsky.social · Feb 5

Representational drift in CA1? We find hidden features of stability in the internal geometry of population activity, which might help to maintain a stable downstream readout. Now preprinted thanks to a great collaboration w/ @olechsylte.bsky.social , @antjekilias.bsky.social and Marlene Bartos. 👇

Ole Christian Sylte @olechsylte.bsky.social · Feb 5

Stable maps from drifting neurons: CA1 solves the "representational drift paradox" through coordinated population dynamics.

New preprint w/ @antjekilias.bsky.social , Marlene Bartos and @jf-sauer.bsky.social showing that representational drift isn’t random—it’s structured to preserve information🧵👇

Coordinated representational drift supports stable place coding in hippocampal CA1

The phenomenon of representational drift (i.e., changing neuronal tuning during repeated exposure to the same stimuli), is a fundamental paradox in neuroscience that raises the question how stable beh...

www.biorxiv.org

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Reposted by Jonas Sauer

Ute Häussler @ute-fr.bsky.social · Jan 20

Our new preprint on long-term low-frequency stimulation in MTLE is online. We show that LFS has lasting effects on seizures even during stimulation-free periods and induces ultrastructural changes at the PP synapse.

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · Jan 20

Long-term hippocampal low-frequency stimulation alleviates focal seizures, memory deficits and synaptic pathology in epileptic mice https://www.biorxiv.org/content/10.1101/2025.01.16.633322v1

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Jonas Sauer @jf-sauer.bsky.social · Jan 16

Thanks a lot!

Jonas Sauer @jf-sauer.bsky.social · Jan 16

I am honoured to join Saarland University as Professor of Physiology in February 2025. My department will focus on the network mechanisms of learning, with particular interest in synaptic function & computations of large neuronal populations. We are hiring, so feel free to get in touch!

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