Orestis Savva
@orestissavva.bsky.social
Just another PhD student trying to make it in this world 🌎
White Rose 🏵 DTP (Sheffield)
🇨🇾🇬🇷
White Rose 🏵 DTP (Sheffield)
🇨🇾🇬🇷
Reposted by Orestis Savva
Cryo-EM ligand building using AlphaFold3-like model and molecular dynamics pubmed.ncbi.nlm.nih.gov/40788932/ #cryoem
August 12, 2025 at 9:33 PM
Cryo-EM ligand building using AlphaFold3-like model and molecular dynamics pubmed.ncbi.nlm.nih.gov/40788932/ #cryoem
Reposted by Orestis Savva
Cool and collected: Advances in sample preparation for cryo-electron microscopy pubmed.ncbi.nlm.nih.gov/40784122/ #cryoem
August 11, 2025 at 8:58 PM
Cool and collected: Advances in sample preparation for cryo-electron microscopy pubmed.ncbi.nlm.nih.gov/40784122/ #cryoem
Reposted by Orestis Savva
Human ribosome interactions reframe neomycin toxicity www.biorxiv.org/content/10.1101/2025.07.22.666027v1 #cryoem
July 27, 2025 at 7:10 AM
Human ribosome interactions reframe neomycin toxicity www.biorxiv.org/content/10.1101/2025.07.22.666027v1 #cryoem
Reposted by Orestis Savva
We have written up a tutorial on how to run BindCraft, how to prepare your input PDB, how to select hotspots, and various other tips and tricks to get the most out of binder design!
github.com/martinpacesa...
github.com/martinpacesa...
June 30, 2025 at 7:45 PM
We have written up a tutorial on how to run BindCraft, how to prepare your input PDB, how to select hotspots, and various other tips and tricks to get the most out of binder design!
github.com/martinpacesa...
github.com/martinpacesa...
Reposted by Orestis Savva
Time-resolved cryo-electron microscopy can resolve protein motion on millisecond or even microsecond timescales, but the need for highly specialized tools and skills limits the method’s reach
www.nature.com/artic...
www.nature.com/artic...
Freeze frame: cracking molecular motion
Nature - Time-resolved cryo-electron microscopy can resolve protein motion on millisecond or even microsecond timescales, but the need for highly specialized tools and skills limits the method’s...
www.nature.com
June 30, 2025 at 4:22 PM
Time-resolved cryo-electron microscopy can resolve protein motion on millisecond or even microsecond timescales, but the need for highly specialized tools and skills limits the method’s reach
www.nature.com/artic...
www.nature.com/artic...
Reposted by Orestis Savva
New research shows that simply changing how a reaction vessel is positioned on a magnetic stirrer can significantly change a reaction's speed and product quality, influencing the reproducibility of results. #ChemSky #ScienceSky #EduSky
Position of flask on magnetic stirrers can drastically affect reproducibility of experiments
Comprehensive examination reveals improper siting of reaction vessels can affect catalyst formation, alter nanoparticle formation and change yields
www.chemistryworld.com
June 26, 2025 at 2:35 PM
New research shows that simply changing how a reaction vessel is positioned on a magnetic stirrer can significantly change a reaction's speed and product quality, influencing the reproducibility of results. #ChemSky #ScienceSky #EduSky
Reposted by Orestis Savva
Structural studies on ribosomes of differentially macrolide-resistant Staphylococcus aureus strains pubmed.ncbi.nlm.nih.gov/40490363/ #cryoem
June 10, 2025 at 3:48 PM
Structural studies on ribosomes of differentially macrolide-resistant Staphylococcus aureus strains pubmed.ncbi.nlm.nih.gov/40490363/ #cryoem
Reposted by Orestis Savva
A great read on how flexibility and air–water interface interactions impact SPA cryo-EM data quality! Congratulations @isobelhirst.bsky.social @stemuench.bsky.social @scarfflab.bsky.social and the team!
I’m very happy to share my first paper on the effects of AWI interactions and flexibility on SPA data quality! Thank you to everyone on the team 🤩
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Untangling the effects of flexibility and the AWI in cryoEM sample preparation: A case study using KtrA
Single particle cryo-electron microscopy (cryoEM) is a powerful tool for elucidating the structures of biological macromolecules without requiring cry…
www.sciencedirect.com
June 2, 2025 at 5:32 PM
A great read on how flexibility and air–water interface interactions impact SPA cryo-EM data quality! Congratulations @isobelhirst.bsky.social @stemuench.bsky.social @scarfflab.bsky.social and the team!
Reposted by Orestis Savva
Illuminating ubiquitination mechanisms: How cryo-EM has shed light on Cullin RING E3 ligase function pubmed.ncbi.nlm.nih.gov/40311545/ #cryoem
May 2, 2025 at 8:19 PM
Illuminating ubiquitination mechanisms: How cryo-EM has shed light on Cullin RING E3 ligase function pubmed.ncbi.nlm.nih.gov/40311545/ #cryoem
Reposted by Orestis Savva
Missed any of the Fragment-Screen webinars with @instruct-eric.bsky.social?
Take a look at them here, with talks from @ceitec.eu, @ebi.embl.org, IBM Research and FFULisboa!
fragmentscreen.org/news-and-eve...
Take a look at them here, with talks from @ceitec.eu, @ebi.embl.org, IBM Research and FFULisboa!
fragmentscreen.org/news-and-eve...
April 23, 2025 at 9:04 AM
Missed any of the Fragment-Screen webinars with @instruct-eric.bsky.social?
Take a look at them here, with talks from @ceitec.eu, @ebi.embl.org, IBM Research and FFULisboa!
fragmentscreen.org/news-and-eve...
Take a look at them here, with talks from @ceitec.eu, @ebi.embl.org, IBM Research and FFULisboa!
fragmentscreen.org/news-and-eve...
Reposted by Orestis Savva
Protein structure prediction via deep learning: an in-depth review pubmed.ncbi.nlm.nih.gov/40248099/ #cryoem
April 20, 2025 at 12:25 AM
Protein structure prediction via deep learning: an in-depth review pubmed.ncbi.nlm.nih.gov/40248099/ #cryoem
Reposted by Orestis Savva
Unraveling the proton-sensing mechanisms of G protein-coupled receptors: Insights from cryogenic electron microscopy studies pubmed.ncbi.nlm.nih.gov/40250408/ #cryoem
April 19, 2025 at 12:55 PM
Unraveling the proton-sensing mechanisms of G protein-coupled receptors: Insights from cryogenic electron microscopy studies pubmed.ncbi.nlm.nih.gov/40250408/ #cryoem
Reposted by Orestis Savva
The code & camera-ready version of our #ICLR2025 paper on "Multi-domain Distribution Learning for De Novo Drug Design" are now available
📚 Paper: openreview.net/forum?id=g3V...
💻 Code: github.com/LPDI-EPFL/Dr...
(1/4)
📚 Paper: openreview.net/forum?id=g3V...
💻 Code: github.com/LPDI-EPFL/Dr...
(1/4)
March 7, 2025 at 1:38 PM
The code & camera-ready version of our #ICLR2025 paper on "Multi-domain Distribution Learning for De Novo Drug Design" are now available
📚 Paper: openreview.net/forum?id=g3V...
💻 Code: github.com/LPDI-EPFL/Dr...
(1/4)
📚 Paper: openreview.net/forum?id=g3V...
💻 Code: github.com/LPDI-EPFL/Dr...
(1/4)
Reposted by Orestis Savva
The structural diversity of psychedelic drug actions revealed pubmed.ncbi.nlm.nih.gov/40108183/ #cryoem
March 22, 2025 at 2:20 AM
The structural diversity of psychedelic drug actions revealed pubmed.ncbi.nlm.nih.gov/40108183/ #cryoem
Reposted by Orestis Savva
Structure-guided design of partial agonists at an opioid receptor pubmed.ncbi.nlm.nih.gov/40082451/ #cryoem
March 16, 2025 at 3:52 AM
Structure-guided design of partial agonists at an opioid receptor pubmed.ncbi.nlm.nih.gov/40082451/ #cryoem
Reposted by Orestis Savva
Protein bL38 facilitates incorporation of uL6 during assembly of the 50S subunit in Flavobacterium johnsoniae pubmed.ncbi.nlm.nih.gov/39997215/ #cryoem
February 26, 2025 at 8:43 PM
Protein bL38 facilitates incorporation of uL6 during assembly of the 50S subunit in Flavobacterium johnsoniae pubmed.ncbi.nlm.nih.gov/39997215/ #cryoem
Reposted by Orestis Savva
Reposted by Orestis Savva
HflX-mediated drug resistance through ribosome splitting and rRNA disordering in mycobacteria pubmed.ncbi.nlm.nih.gov/39913204/ #cryoem
February 8, 2025 at 12:36 AM
HflX-mediated drug resistance through ribosome splitting and rRNA disordering in mycobacteria pubmed.ncbi.nlm.nih.gov/39913204/ #cryoem
Reposted by Orestis Savva
Reposted by Orestis Savva
The binding of RbgA to a critical 50S assembly intermediate facilitates YphC function in bacterial ribosomal assembly pubmed.ncbi.nlm.nih.gov/39658043/
December 11, 2024 at 3:04 PM
The binding of RbgA to a critical 50S assembly intermediate facilitates YphC function in bacterial ribosomal assembly pubmed.ncbi.nlm.nih.gov/39658043/
Apparently, everyone is moving to Blue Sky now...
December 7, 2024 at 11:08 AM
Apparently, everyone is moving to Blue Sky now...