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Reposted by Pablo Ivan Nikel

labnikel.bsky.social @labnikel.bsky.social · Aug 22

🚨 New paper in mBio!
We established strict formatotrophic & methylotrophic growth in engineered Pseudomonas putida via the reductive glycine pathway (rGlyP). journals.asm.org/doi/full/10....
Here’s a teaser of how we did it 🧵👇1/5

Synthetic C1 metabolism in Pseudomonas putida enables strict formatotrophy and methylotrophy via the reductive glycine pathway | mBio

Soluble C1 feedstocks, such as formate and methanol, have gained attention as sustainable substrates for biotechnology, with the potential to reduce greenhouse gas emissions and reliance on sugar-based resources. Despite their promise, the metabolic ...

journals.asm.org

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Reposted by Pablo Ivan Nikel

labnikel.bsky.social @labnikel.bsky.social · 4h

3/4 Our perspective lays out:
1️⃣ A blueprint for designing next-gen synthetic C1 microbes
2️⃣ A roadmap for engineering P. putida into an autotrophic chassis
3️⃣ A circular carbon economy vision, revalorizing CO₂ + waste streams
📊 Together, these steps connect design → engineering → sustainability.

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Reposted by Pablo Ivan Nikel

labnikel.bsky.social @labnikel.bsky.social · 4h

🚀 Thrilled to share our new Nature Communications article:
“A blueprint for designing the next-generation of synthetic C1 microbes”
We propose a framework to unlock sustainable, carbon-efficient biomanufacturing using non-canonical hosts.
🔗 www.nature.com/articles/s41... A short 🧵1/4

A blueprint for designing the next-generation of synthetic C1 microbes - Nature Communications

Synthetic one-carbon assimilation could contribute to a more sustainable and circular carbon economy, but much work in this field has focused on model microorganisms. Here the authors provide their perspective on the potential value of non-model microbes, and how that potential could be realised.

www.nature.com

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Pablo Ivan Nikel @pabnik.bsky.social · 5d

A blueprint for designing the next-generation of #synthetic C1 #microbes @natureportfolio.nature.com / We outline how to engineer non-canonical hosts, apply modeling & C1-inducible promoters & integrate sustainability metrics for carbon-efficient #biomanufacturing
www.nature.com/articles/s41...

A blueprint for designing the next-generation of synthetic C1 microbes - Nature Communications

Synthetic one-carbon assimilation could contribute to a more sustainable and circular carbon economy, but much work in this field has focused on model microorganisms. Here the authors provide their perspective on the potential value of non-model microbes, and how that potential could be realised.

www.nature.com

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Pablo Ivan Nikel @pabnik.bsky.social · 14d

The very 1st #Course on #SynBio & #Metabolic #Engineering of #Pseudomonas at Cold Spring Harbor Asia successfully completed in Suzhou, #China! Excellent group of students & lecturers, w/time for culture, food & stand-up paddling alongside the science—thanks to all who participated & stay tuned 4+!

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Reposted by Pablo Ivan Nikel

International Microbiology Literacy Initiative - IMiLI @imili-micro.bsky.social · 14d

Welcome to the social media account of the International Microbiology Literacy Initiative (IMiLI). Nearly 1,000 researchers freely contribute to the IMiLI project integrating microbiology into education providing downloadable resources for all. Explore at imili.org

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Reposted by Pablo Ivan Nikel

Victor de Lorenzo (CNB, Madrid) @vdlorenzo.bsky.social · 14d

Who is afraid of HGT? True, antibiotic resistances disseminate through it. But we can also leverage the same channels for spreading good stuff at a very large scale and fortifying the env microbiome with beneficial activities www.biorxiv.org/content/10.1... by Victor Maull & @ricardsole.bsky.social

Synthetic Horizontal Gene Transfer for Ecosystem Restoration

Restoring endangered ecosystems has become a pressing issue as the effects of global warming continue to harm existing communities. Over the last decade, several studies have suggested the use of synt...

www.biorxiv.org

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Pablo Ivan Nikel @pabnik.bsky.social · Sep 5

Here is Andrew’s obituary, where you can share a tribute or plant a tree in his memory as a way to honor his life 🕊️
www.forestmeadowsfh.com/obituaries/A...

Obituary information for Andrew Donald Hanson

View Andrew Donald Hanson's obituary, contribute to their memorial, see their funeral service details, and more.

www.forestmeadowsfh.com

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Reposted by Pablo Ivan Nikel

Andreas P.M. Weber 🌾🌱🧬 @apmweber.bsky.social · Sep 3

We are deeply saddened by the news that Andrew D. Hanson (@adhansonlab.bsky.social) is no longer with us. He was an exceptional scientist, mentor, and leader in multiple fields. He constantly reminded us that over-promising would backfire. Rest in peace, Andrew.

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Pablo Ivan Nikel @pabnik.bsky.social · Sep 3

Andrew was a force of nature. He remained active until the very end and wrote a couple of very moving, lucid, and sharp farewell emails that I will always treasure. R.I.P. Andrew 🕊️

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Pablo Ivan Nikel @pabnik.bsky.social · Sep 2

Delighted to join #MetabolicEngineering as Associate Editor w/Sang Yup Lee, Jay Keasling, I. Borodina, C. Maranas & C. Wittmann. I'll handle submissions in #SyntheticMetabolism, #Pseudomonas, #SynBio, new-to-nature #bioproduction & #EnvironmentalBiotechnology!

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Pablo Ivan Nikel @pabnik.bsky.social · Aug 21

Saying goodbye to Elio Schaechter, a titan of the #Microbiology field. Farewell Elio!

STCmicrobeblog @stcmicrobeblog.bsky.social · Aug 21

schaechter.asmblog.org/schaechter/2...
#MicroSky

Elio (1928-2025)

by The STC Team — Losing a close friend always saddens one deeply, regardless of age. Losing a person who has so immensely influenced our worldview through his guidance and example makes the sadness e...

schaechter.asmblog.org

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Pablo Ivan Nikel @pabnik.bsky.social · Aug 21

#Synthetic C1 #metabolism in #Pseudomonas putida enables strict formatotrophy and methylotrophy via the reductive glycine pathway—led by J. Turlin, M. G. Alván, @oscarpuiggene.bsky.social w/@stefanodonati.bsky.social & @sebwenk.bsky.social @mbio.bsky.social #SynBio
journals.asm.org/doi/10.1128/...

Synthetic C1 metabolism in Pseudomonas putida enables strict formatotrophy and methylotrophy via the reductive glycine pathway | mBio

Soluble C1 feedstocks, such as formate and methanol, have gained attention as sustainable substrates for biotechnology, with the potential to reduce greenhouse gas emissions and reliance on sugar-based resources. Despite their promise, the metabolic ...

journals.asm.org

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Reposted by Pablo Ivan Nikel

sevaplasmids.bsky.social @sevaplasmids.bsky.social · Jul 16

🔍Problems with synthetic C1 metabolism? The @pabnik.bsky.social group identifies seven major barriers limiting its deployment in microorganisms and proposes specific strategies to overcome each of them. Check out their paper 👉https://doi.org/10.1093/femsre/fuaf011

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Reposted by Pablo Ivan Nikel

TOLERATE EU Project @tolerateeu.bsky.social · Jul 15

📍 Milan | TODAY!
Join Amedea Perfumo & @pabnik.bsky.social at #FEMS 2025 for a dynamic session🧬 "Something (very) old, something new: Innovative microbial solutions for sustainability challenges
🕦 15 July | 11:30–13:00 | Tower Lounge
🔗 femsmicro.org
▶️ youtu.be/0-bhcMpjJ_c
#TolerateEUProject

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Pablo Ivan Nikel @pabnik.bsky.social · Jul 13

Looking forward to see old MicroFriends and make some new ones at #FEMS2025!

Hilary Lappin-Scott @lappinscott.bsky.social · Jul 13

It’s all getting very exciting now as #fems2025 commences tomorrow! Milan is such a beautiful city too

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Reposted by Pablo Ivan Nikel

labnikel.bsky.social @labnikel.bsky.social · Jul 9

Check out our newest article led by @oscarpuiggene.bsky.social !

Pablo Ivan Nikel @pabnik.bsky.social · Jul 7

Implementing synthetic serine cycles in #Pseudomonas putida unlock methanol assimilation in our favorite bug w/carbon conservation, led by ÒscarPuiggené @labnikel.bsky.social · #SynBio #MetabolicEngineering #Methanol published in @cp-trendsbiotech.bsky.social
www.sciencedirect.com/science/arti...

Systematic engineering of synthetic serine cycles in Pseudomonas putida uncovers emergent topologies for methanol assimilation

The urgent need for a circular carbon economy has driven research into sustainable substrates, including one-carbon (C1) compounds. The non-pathogenic…

www.sciencedirect.com

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Reposted by Pablo Ivan Nikel

labnikel.bsky.social @labnikel.bsky.social · Jul 9

The 5th edition of the #Pseudomonas grass roots meeting will take place on the 27th/28th of October 2025 in Denmark. This year, our group at DTU Biosustain will host 2 exciting days of networking, exchanging ideas and learning for early career-stage scientists working with Pseudomonas. 👇

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Reposted by Pablo Ivan Nikel

sevaplasmids.bsky.social @sevaplasmids.bsky.social · Jul 9

🧬 The language of SEVA expands! The group of @pabnik.bsky.social use #SEVAplasmids nomenclature in the design of CIFR—a novel iterative transposon tool for genomic engineering of Gam-negative bacteria. 👉 doi.org/10.1016/j.ym...

Redirecting

doi.org

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Pablo Ivan Nikel @pabnik.bsky.social · Jul 9

🚨 Due to popular demand, the deadline to apply for the @cshlnews.bsky.social course Advanced #SynBio & #Metabolic #Engineering of #Pseudomonas is extended to July 22! #PhD students & #postdocs welcome!
📍Suzhou, China
📅 Sept 7–21
🔗Apply now: csh-asia.org?content/2642

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Pablo Ivan Nikel @pabnik.bsky.social · Jul 7

Implementing synthetic serine cycles in #Pseudomonas putida unlock methanol assimilation in our favorite bug w/carbon conservation, led by ÒscarPuiggené @labnikel.bsky.social · #SynBio #MetabolicEngineering #Methanol published in @cp-trendsbiotech.bsky.social
www.sciencedirect.com/science/arti...

Systematic engineering of synthetic serine cycles in Pseudomonas putida uncovers emergent topologies for methanol assimilation

The urgent need for a circular carbon economy has driven research into sustainable substrates, including one-carbon (C1) compounds. The non-pathogenic…

www.sciencedirect.com

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Reposted by Pablo Ivan Nikel

TOLERATE EU Project @tolerateeu.bsky.social · Jun 30

Today, the #TOLERATEProject held its 1st Review Meeting (M1–M18) with PO & PM highlighting our progress, innovation & first results. A key step to shape the road ahead! 🔬🌱💦
Learn more: https://tolerate-eu-project.com/

#HorizonEurope #EUProjects #Biotechnology #SustainableAgriculture

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Reposted by Pablo Ivan Nikel

TOLERATE EU Project @tolerateeu.bsky.social · Jul 1

🌱⚖️ Is EU law keeping up with agri-food innovation?
Our latest TOLERATE article explores how outdated GMO/NGT rules could hinder progress.
Thanks to Mirta Alessandrini & Francesco Montanari for their legal insights.
👉 Read more: tolerate-eu-project.com/tolerate-agr...

TOLERATE - Agri-food Science & Law Join Forces Against Climate ChangeResurrecting Ancient Genes with Synthetic Biology to Tackle Modern Challenges - Cyprus Institute of Neurology & Genetics

Setting the scene Agriculture has been the most important source of sustenance for mankind for thousands of years. However, current farming practices are often singled out as key drivers of climate ch...

tolerate-eu-project.com

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Pablo Ivan Nikel @pabnik.bsky.social · Jun 30

Rhodotorula?

Reposted by Pablo Ivan Nikel

labnikel.bsky.social @labnikel.bsky.social · Jun 23

Back from an inspiring week at #ME16 in our home #Copenhagen! 🌍

Engaging talks, exciting science, and amazing connections — we’re full of new ideas!

🎉 Big congrats to @giusifav.bsky.social for winning a poster award 🏆
🙌 And proud to have our PI @pabnik.bsky.social as co-chair of the event!

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