Patricia Benčić
@patriciabencic.bsky.social
Pharmacist | Postdoc at LCBM (EPFL) in 🇨🇭.
Nucleic acids and their (synthetic) modification 🧬
Nucleic acids and their (synthetic) modification 🧬
Pinned
Doping In Vivo Alkylation in E. coli by Introducing the Direct Sulfurylation Pathway of S. cerevisiae
S-Adenosylmethionine-dependent methyltransferases are emerging enzymes for selective biocatalytic alkylation. Introduction of the direct sulfurylation pathway from S. cerevisiae improved methylation ...
doi.org
Doping, but make it biocatalysis!I’ve had an amazing time collaborating with the Andexer Group at ALU Freiburg on this project we’re happy to have published in Angewandte Chemie.
#biocatalysis #methyltransferases
#AdoMet
doi.org/10.1002/anie...
#biocatalysis #methyltransferases
#AdoMet
doi.org/10.1002/anie...
Amazing work by my (unfortunately former) colleague @alexateslenko.bsky.social
Check out our new study of chromatin ubiquitylation. @alexateslenko.bsky.social visualized directly at single molecule scale how vPRC1 ubiquitylates neighboring nucleosomes. These results suggest potential mechanism on how H2Aub domains are established. 👇👇👇
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Single-molecule analysis reveals the mechanism of chromatin ubiquitylation by variant PRC1 complexes
Single-molecule experiments show that active conformation formation controls chromatin ubiquitylation kinetics by variant PRC1.
www.science.org
May 28, 2025 at 7:52 AM
Amazing work by my (unfortunately former) colleague @alexateslenko.bsky.social
Join us May 19th to May 21st for Pint of Science in Lausanne!
The program for Pint of Science Lausanne 🧪 is ready!
pintofscience.ch/events/lausa...
This year we have again three venues covering topics from aging to robotic surgery or sustainable agriculture
Come join us on the 19th, 20th and 21st of May 🥳
#PintCH #scicomm @pintofscience.ch
pintofscience.ch/events/lausa...
This year we have again three venues covering topics from aging to robotic surgery or sustainable agriculture
Come join us on the 19th, 20th and 21st of May 🥳
#PintCH #scicomm @pintofscience.ch
Lausanne
Explore Pint of Science Switzerland events in Lausanne
pintofscience.ch
April 24, 2025 at 10:21 AM
Join us May 19th to May 21st for Pint of Science in Lausanne!
Reposted by Patricia Benčić
Cryogenic Electron Microscopy: MagIC beads for scarce macromolecules. #CryoEm
https://elifesciences.org/articles/105335?utm_source=bluesky&utm_medium=social&utm_campaign=organic_insights
https://elifesciences.org/articles/105335?utm_source=bluesky&utm_medium=social&utm_campaign=organic_insights
January 25, 2025 at 9:21 AM
Cryogenic Electron Microscopy: MagIC beads for scarce macromolecules. #CryoEm
https://elifesciences.org/articles/105335?utm_source=bluesky&utm_medium=social&utm_campaign=organic_insights
https://elifesciences.org/articles/105335?utm_source=bluesky&utm_medium=social&utm_campaign=organic_insights
When you’ve actually wanted to be a paleontologist…
#biologistswhobake
#biologistswhobake
December 15, 2024 at 7:30 PM
When you’ve actually wanted to be a paleontologist…
#biologistswhobake
#biologistswhobake
Reposted by Patricia Benčić
New preprint @chemrxiv.bsky.social on discovery of macrocyclic inhibitors of HDAC11 with the Christian Heinis #EPFL
Main contributors @danieladankova.bsky.social, @alexanderln.bsky.social, @carlosmyruela.bsky.social
🙏 @ERC_Research, @novonordiskfond, @DFF_raad for 💶
chemrxiv.org/engage/chemr...
Main contributors @danieladankova.bsky.social, @alexanderln.bsky.social, @carlosmyruela.bsky.social
🙏 @ERC_Research, @novonordiskfond, @DFF_raad for 💶
chemrxiv.org/engage/chemr...
December 10, 2024 at 2:28 PM
New preprint @chemrxiv.bsky.social on discovery of macrocyclic inhibitors of HDAC11 with the Christian Heinis #EPFL
Main contributors @danieladankova.bsky.social, @alexanderln.bsky.social, @carlosmyruela.bsky.social
🙏 @ERC_Research, @novonordiskfond, @DFF_raad for 💶
chemrxiv.org/engage/chemr...
Main contributors @danieladankova.bsky.social, @alexanderln.bsky.social, @carlosmyruela.bsky.social
🙏 @ERC_Research, @novonordiskfond, @DFF_raad for 💶
chemrxiv.org/engage/chemr...
Reposted by Patricia Benčić
#IchBinHanna schreibt ihren Wunschzettel! Es braucht endlich Perspektiven für Wissenschaft als Beruf! Kein #Wahlprogramm ohne Hanna! @spdde.bsky.social @gruene.de @dielinkebt.bsky.social
December 1, 2024 at 2:16 PM
#IchBinHanna schreibt ihren Wunschzettel! Es braucht endlich Perspektiven für Wissenschaft als Beruf! Kein #Wahlprogramm ohne Hanna! @spdde.bsky.social @gruene.de @dielinkebt.bsky.social
Reposted by Patricia Benčić
Want to see how PRC1 writes the Polycomb ubiquitin mark on chromatin, in real-time? Check out our latest preprint, done all by Alexandra Teslenko at ISIC EPFL, a tour-de-force of single-molecule enzymology!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Single-molecule analysis reveals the mechanism of chromatin ubiquitylation by variant PRC1 complexes
Chromatin regulation relies on "writer" enzymes that add post-translational modifications (PTMs) to histone proteins. Variant Polycomb repressive complex 1 (PRC1) exists as several subtypes, which are...
www.biorxiv.org
November 1, 2024 at 11:29 AM
Want to see how PRC1 writes the Polycomb ubiquitin mark on chromatin, in real-time? Check out our latest preprint, done all by Alexandra Teslenko at ISIC EPFL, a tour-de-force of single-molecule enzymology!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Doping, but make it biocatalysis!I’ve had an amazing time collaborating with the Andexer Group at ALU Freiburg on this project we’re happy to have published in Angewandte Chemie.
#biocatalysis #methyltransferases
#AdoMet
doi.org/10.1002/anie...
#biocatalysis #methyltransferases
#AdoMet
doi.org/10.1002/anie...
Doping In Vivo Alkylation in E. coli by Introducing the Direct Sulfurylation Pathway of S. cerevisiae
S-Adenosylmethionine-dependent methyltransferases are emerging enzymes for selective biocatalytic alkylation. Introduction of the direct sulfurylation pathway from S. cerevisiae improved methylation ...
doi.org
November 16, 2024 at 9:04 AM
Doping, but make it biocatalysis!I’ve had an amazing time collaborating with the Andexer Group at ALU Freiburg on this project we’re happy to have published in Angewandte Chemie.
#biocatalysis #methyltransferases
#AdoMet
doi.org/10.1002/anie...
#biocatalysis #methyltransferases
#AdoMet
doi.org/10.1002/anie...