Penn Epigenetics Institute
@pennepigenetics.bsky.social
Penn Epigenetics Institute at The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
Reposted by Penn Epigenetics Institute
Check out the spotlight @cambupenn.bsky.social student Lexie Schneider and I wrote about research demonstrating that Dad’s that exercise have sons that are more physically fit which is inherited by regulating miRNAs in sperm
Online Now: Run for your sons: paternal exercise boosts offspring fitness #trends #endocrinology #metabolism
Run for your sons: paternal exercise boosts offspring fitness
Once controversial, paternal nongenetic inheritance is becoming widely accepted. In a recent study, Yin et al. expand this burgeoning field by demonstrating that the benefits of paternal exercise are passed to progeny via modulating sperm miRNAs. These sperm miRNAs regulate the corepressor NCor1 during embryogenesis to casually transmit improved fitness and metabolism to offspring.
dlvr.it
November 21, 2025 at 1:33 PM
Check out the spotlight @cambupenn.bsky.social student Lexie Schneider and I wrote about research demonstrating that Dad’s that exercise have sons that are more physically fit which is inherited by regulating miRNAs in sperm
Reposted by Penn Epigenetics Institute
Pleased to share the programme for #GenReg26 is now live!
Head to the website to check out the sessions & speakers shaping our second edition➡️ bit.ly/3LGC4Cg
If you haven’t registered yet, now’s the time - final deadlines are fast approaching!⌛️
Head to the website to check out the sessions & speakers shaping our second edition➡️ bit.ly/3LGC4Cg
If you haven’t registered yet, now’s the time - final deadlines are fast approaching!⌛️
November 13, 2025 at 10:35 AM
Pleased to share the programme for #GenReg26 is now live!
Head to the website to check out the sessions & speakers shaping our second edition➡️ bit.ly/3LGC4Cg
If you haven’t registered yet, now’s the time - final deadlines are fast approaching!⌛️
Head to the website to check out the sessions & speakers shaping our second edition➡️ bit.ly/3LGC4Cg
If you haven’t registered yet, now’s the time - final deadlines are fast approaching!⌛️
Reposted by Penn Epigenetics Institute
Andrew Katznelson (@andykatznelson.bsky.social) in the Zaret lab defends his thesis tomorrow!
November 18, 2025 at 6:30 PM
Andrew Katznelson (@andykatznelson.bsky.social) in the Zaret lab defends his thesis tomorrow!
Reposted by Penn Epigenetics Institute
Congrats to @annavoss.bsky.social on a fantastic poster presentation at SFN today!!! Stay tuned for more on her work in the future on links between histone variant H2BE and a novel neurodevelopmental disorder.
November 18, 2025 at 1:45 AM
Congrats to @annavoss.bsky.social on a fantastic poster presentation at SFN today!!! Stay tuned for more on her work in the future on links between histone variant H2BE and a novel neurodevelopmental disorder.
Reposted by Penn Epigenetics Institute
Also, here’s an accessible video intro:
November 15, 2025 at 5:33 PM
Also, here’s an accessible video intro:
Reposted by Penn Epigenetics Institute
So awesome to have this great paper from Sam Reffsin and Sara Cherry out! In it, we use retrospective clone tracing to show that there are particular single cell states that are more susceptible to viral infection (both SARS-CoV-2 and flu)!
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Single-cell susceptibility to viral infection is driven by variable cell states
Not all cells that can be infected by a virus become infected with that virus. Single-cell
clone tracing reveals intrinsic cell states with variable expression patterns that
increase susceptibility to...
www.cell.com
November 14, 2025 at 4:47 PM
So awesome to have this great paper from Sam Reffsin and Sara Cherry out! In it, we use retrospective clone tracing to show that there are particular single cell states that are more susceptible to viral infection (both SARS-CoV-2 and flu)!
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Penn Epigenetics Institute
ft. Lee, Goldberg, Cloud, Kim, Zhao (@chopresearch.bsky.social), Parker, Kohli (@penn-id.bsky.social), Krapp, @marisa-bartolomei.bsky.social (CDB), Loo (BioBio), Jin (@penncbio.bsky.social) & @zhouwanding.bsky.social (@pennpathlabmed.bsky.social) genomebiology.biomedcentral.com/articles/10....
October 28, 2025 at 4:27 PM
ft. Lee, Goldberg, Cloud, Kim, Zhao (@chopresearch.bsky.social), Parker, Kohli (@penn-id.bsky.social), Krapp, @marisa-bartolomei.bsky.social (CDB), Loo (BioBio), Jin (@penncbio.bsky.social) & @zhouwanding.bsky.social (@pennpathlabmed.bsky.social) genomebiology.biomedcentral.com/articles/10....
Reposted by Penn Epigenetics Institute
Super proud of Dr. @giannatbusch.bsky.social for successfully defending her thesis! Such a talented and wonderful human!
October 26, 2025 at 6:33 PM
Super proud of Dr. @giannatbusch.bsky.social for successfully defending her thesis! Such a talented and wonderful human!
Reposted by Penn Epigenetics Institute
Congratulations to Elizabeth Traxler (@penncancer.bsky.social), recipient of the NIH Director's Early Independence Award! Learn more about Dr. Traxler & her research interests here➡️ tinyurl.com/56kv62yu #NIHHighRisk
October 21, 2025 at 7:40 PM
Congratulations to Elizabeth Traxler (@penncancer.bsky.social), recipient of the NIH Director's Early Independence Award! Learn more about Dr. Traxler & her research interests here➡️ tinyurl.com/56kv62yu #NIHHighRisk
Reposted by Penn Epigenetics Institute
Congratulations to Gerd Blobel (@chopresearch.bsky.social/ @pennmedicine.bsky.social/ @pennepigenetics.bsky.social) on his election to the National Academy of Medicine! Learn more about Dr. Blobel & his research here➡️ blobellab.squarespace.com #PSOMatNAM @nam.edu
October 22, 2025 at 5:03 PM
Congratulations to Gerd Blobel (@chopresearch.bsky.social/ @pennmedicine.bsky.social/ @pennepigenetics.bsky.social) on his election to the National Academy of Medicine! Learn more about Dr. Blobel & his research here➡️ blobellab.squarespace.com #PSOMatNAM @nam.edu
Reposted by Penn Epigenetics Institute
Congratulations to the 3 @pennmedicine.bsky.social honorees elected to the National Academy of Medicine! Election to @nam.edu is considered one of the highest honors in the field of health & medicine. Check back this week as we profile each new member tinyurl.com/ysjzdrbk
October 22, 2025 at 12:44 PM
Congratulations to the 3 @pennmedicine.bsky.social honorees elected to the National Academy of Medicine! Election to @nam.edu is considered one of the highest honors in the field of health & medicine. Check back this week as we profile each new member tinyurl.com/ysjzdrbk
Reposted by Penn Epigenetics Institute
Male mice that exercise can pass their newly gained fitness on to male offspring.
If the same holds true in humans, researchers say, fathers could help improve the health of any future children by staying in shape themselves. https://scim.ag/47igpZm
If the same holds true in humans, researchers say, fathers could help improve the health of any future children by staying in shape themselves. https://scim.ag/47igpZm
Well-exercised male mice appear to pass fitness to their male offspring
Surprising epigenetic effect relies on snippets of RNA packaged within sperm
scim.ag
October 13, 2025 at 1:30 PM
Male mice that exercise can pass their newly gained fitness on to male offspring.
If the same holds true in humans, researchers say, fathers could help improve the health of any future children by staying in shape themselves. https://scim.ag/47igpZm
If the same holds true in humans, researchers say, fathers could help improve the health of any future children by staying in shape themselves. https://scim.ag/47igpZm
Reposted by Penn Epigenetics Institute
Congratulations to the impressive list of @pennmedicine.bsky.social scientists awarded NIH Director's high-risk, high-reward research grants! These #NIHHighRisk awards fund innovative & impactful biomedical research. Check back as we profile each winner➡️ tinyurl.com/2prk75be
October 14, 2025 at 8:18 PM
Congratulations to the impressive list of @pennmedicine.bsky.social scientists awarded NIH Director's high-risk, high-reward research grants! These #NIHHighRisk awards fund innovative & impactful biomedical research. Check back as we profile each winner➡️ tinyurl.com/2prk75be
Reposted by Penn Epigenetics Institute
The BGS program is partnering with the Community 4 Rigor (@comm4rigor) to offer a two-part workshop series designed to help you prepare for the Preliminary Exam, and strengthen your rigor mindset and skills. @cambupenn prelim students RSVP to save your spot today! forms.monday.com/forms/4c859e...
October 15, 2025 at 1:31 PM
The BGS program is partnering with the Community 4 Rigor (@comm4rigor) to offer a two-part workshop series designed to help you prepare for the Preliminary Exam, and strengthen your rigor mindset and skills. @cambupenn prelim students RSVP to save your spot today! forms.monday.com/forms/4c859e...
Reposted by Penn Epigenetics Institute
In this article, I share my perspective on leveraging AI and single-cell profiling to predict type 1 diabetes. It’s great to see the diverse insights contributed by other experts in the field: www.nature.com/articles/s42...
Artificial intelligence in metabolic research - Nature Metabolism
The recent developments in artificial intelligence (AI) have created both intrigue and apprehension in the world of research. In this Viewpoint, we asked 12 experts in the field of metabolism to share their — differing — opinions on the use of AI in pre-clinical and clinical metabolic research.
www.nature.com
October 7, 2025 at 9:26 PM
In this article, I share my perspective on leveraging AI and single-cell profiling to predict type 1 diabetes. It’s great to see the diverse insights contributed by other experts in the field: www.nature.com/articles/s42...
Reposted by Penn Epigenetics Institute
Check out this new Levine-Lampson collaboration, led by the talented Hyuk-Joon Jeon.
We explored the consequences of inheriting long telomeres from dad and short telomeres from mom. Or the reciprocal. Turns out, parent-of-origin matters (in mice, at least).
authors.elsevier.com/c/1loW-3QW8S...
We explored the consequences of inheriting long telomeres from dad and short telomeres from mom. Or the reciprocal. Turns out, parent-of-origin matters (in mice, at least).
authors.elsevier.com/c/1loW-3QW8S...
authors.elsevier.com
October 4, 2025 at 4:40 PM
Check out this new Levine-Lampson collaboration, led by the talented Hyuk-Joon Jeon.
We explored the consequences of inheriting long telomeres from dad and short telomeres from mom. Or the reciprocal. Turns out, parent-of-origin matters (in mice, at least).
authors.elsevier.com/c/1loW-3QW8S...
We explored the consequences of inheriting long telomeres from dad and short telomeres from mom. Or the reciprocal. Turns out, parent-of-origin matters (in mice, at least).
authors.elsevier.com/c/1loW-3QW8S...
Reposted by Penn Epigenetics Institute
Spatial joint profiling of DNA methylome & transcriptome in mammalian tissues ft. @LeeChinNien, @HongxiangFu, Angelysia Cardilla, @zhouwanding & @dengyanxiang.bsky.social (@pennpathlabmed.bsky.social) @nature.com www.nature.com/articles/s41...
October 2, 2025 at 8:00 PM
Spatial joint profiling of DNA methylome & transcriptome in mammalian tissues ft. @LeeChinNien, @HongxiangFu, Angelysia Cardilla, @zhouwanding & @dengyanxiang.bsky.social (@pennpathlabmed.bsky.social) @nature.com www.nature.com/articles/s41...
Reposted by Penn Epigenetics Institute
The Vahedi Lab is seeking a highly motivated Research Specialist A/B to join our dynamic research group studying the mechanisms of immune regulation. Apply here: wd1.myworkdaysite.com/recruiting/u...
Research Specialist A/B
University Overview The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school co...
wd1.myworkdaysite.com
September 23, 2025 at 9:47 PM
The Vahedi Lab is seeking a highly motivated Research Specialist A/B to join our dynamic research group studying the mechanisms of immune regulation. Apply here: wd1.myworkdaysite.com/recruiting/u...
Reposted by Penn Epigenetics Institute
Zachary Gardner in the Jain lab defends his thesis tomorrow!
September 21, 2025 at 5:01 PM
Zachary Gardner in the Jain lab defends his thesis tomorrow!
Reposted by Penn Epigenetics Institute
Students✨ Alumni🎓 Faculty🧪 - Are you registered?! BGS is celebrating 40 years this fall🍂. Everyone who plans to attend should register in advance. For more info and to see who's coming: www.med.upenn.edu/bgs-at-40/
September 18, 2025 at 6:54 PM
Students✨ Alumni🎓 Faculty🧪 - Are you registered?! BGS is celebrating 40 years this fall🍂. Everyone who plans to attend should register in advance. For more info and to see who's coming: www.med.upenn.edu/bgs-at-40/
Reposted by Penn Epigenetics Institute
We’re excited to share that, after receiving many requests each year from the research community for Oligopaint DNA & RNA FISH probes, we’re piloting a service to design & prepare probes for labs.
Please share with colleagues who may benefit!
ericjoycelab.com/oligopaint-f...
Please share with colleagues who may benefit!
ericjoycelab.com/oligopaint-f...
Oligopaint Probe Requests
In an effort to make Oligopaint FISH probes more broadly available to the research community, we offer DNA and RNA FISH probe design, synthesis, and generation. By dedicating a full-time staff memb…
ericjoycelab.com
September 16, 2025 at 5:44 PM
We’re excited to share that, after receiving many requests each year from the research community for Oligopaint DNA & RNA FISH probes, we’re piloting a service to design & prepare probes for labs.
Please share with colleagues who may benefit!
ericjoycelab.com/oligopaint-f...
Please share with colleagues who may benefit!
ericjoycelab.com/oligopaint-f...
Reposted by Penn Epigenetics Institute
Krista Budinich in the Liling Wan Lab has a recent preprint: RNA reinforces condensate nucleation on chromatin to amplify oncogenic transcription pubmed.ncbi.nlm.nih.gov/40766627/
RNA reinforces condensate nucleation on chromatin to amplify oncogenic transcription - PubMed
Aberrant chromatin-associated condensates have emerged as drivers of transcriptional dysregulation in cancer, yet the mechanisms regulating their formation and function remain poorly understood.…
pubmed.ncbi.nlm.nih.gov
September 16, 2025 at 4:03 PM
Krista Budinich in the Liling Wan Lab has a recent preprint: RNA reinforces condensate nucleation on chromatin to amplify oncogenic transcription pubmed.ncbi.nlm.nih.gov/40766627/
Reposted by Penn Epigenetics Institute
Igf2 adult-specific skeletal muscle enhancer activity revealed in mice with intergenic CTCF boundary deletion ft. Joanne Thorvaldsen, Aimee Juan, Yemin Lan, Christopher Krapp & @marisa-bartolomei.bsky.social (@PennCDB/ @pennepigenetics.bsky.social) @PLOSGenetics journals.plos.org/plosgenetics...
September 16, 2025 at 3:08 PM
Igf2 adult-specific skeletal muscle enhancer activity revealed in mice with intergenic CTCF boundary deletion ft. Joanne Thorvaldsen, Aimee Juan, Yemin Lan, Christopher Krapp & @marisa-bartolomei.bsky.social (@PennCDB/ @pennepigenetics.bsky.social) @PLOSGenetics journals.plos.org/plosgenetics...
Reposted by Penn Epigenetics Institute
Dr. Yeqiao Zhou, alum from the Faryabi lab (@faryabi.bsky.social), has a preprint publication on: OLIVE Provides Rapid Visualization and Analysis of Chromatin Tracing Experiments www.biorxiv.org/content/10.1...
OLIVE Provides Rapid Visualization and Analysis of Chromatin Tracing Experiments
Optical chromatin tracing experiments directly capture the three-dimensional folding of thousands of individual alleles, highlighting the need for a tool that enables fast, interactive, and…
www.biorxiv.org
September 11, 2025 at 7:00 PM
Dr. Yeqiao Zhou, alum from the Faryabi lab (@faryabi.bsky.social), has a preprint publication on: OLIVE Provides Rapid Visualization and Analysis of Chromatin Tracing Experiments www.biorxiv.org/content/10.1...
Reposted by Penn Epigenetics Institute
🚨 We're hiring, please share! The FMI seeks a tenure-track Group Leader (Assistant Prof) in Structural Biology 🔬
Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...
Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...
September 8, 2025 at 8:15 AM
🚨 We're hiring, please share! The FMI seeks a tenure-track Group Leader (Assistant Prof) in Structural Biology 🔬
Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...
Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...