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Petra Mocellin @petramoce.bsky.social · Jun 16

A new role for my favorite neuronal population ❤️

Food perception increases the activity of MS glutamatergic neurons, independent of palatability.

Amazing work from the @sophiesteculorum.bsky.social lab!

www.nature.com/articles/s42...

A food-sensitive olfactory circuit drives anticipatory satiety - Nature Metabolism

The authors describe a sensory circuit involving the medial septum (MS), where MS glutamatergic neurons integrate food odours to prime satiety and regulate nutrient intake.

www.nature.com

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Reposted by Petra Mocellin

Yulong Li Lab @yulonglilab.bsky.social · Jun 6

Excited to share our Science paper on HaloDA1.0-the first genetically encoded far-red dopamine sensor! 🥳It enables powerful multiplex imaging in neurons, brain slices, and live animals.🧠🔬 #GRABsensors #Dopamine www.science.org/doi/10.1126/...

In vivo multiplex imaging of dynamic neurochemical networks with designed far-red dopamine sensors

Dopamine (DA) plays a crucial role in a variety of brain functions through intricate interactions with other neuromodulators and intracellular signaling pathways. However, studying these complex netwo...

www.science.org

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Petra Mocellin @petramoce.bsky.social · May 1

Too excited not to share this beauty!
#fluorescenceFriday (but a day earlier)

TH staining in cyan
Virus injection in magenta

Zona Incerta is definitely a tough cookie 🍪 but getting there!

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Reposted by Petra Mocellin

Eshaan Iyer @eshaaniyer.bsky.social · Apr 15

Thrilled to see this part of my PhD work with @rcbagot.bsky.social now out in @natcomms.nature.com!
(1/14)

www.nature.com/articles/s41...

Reward integration in prefrontal-cortical and ventral-hippocampal nucleus accumbens inputs cooperatively modulates engagement - Nature Communications

Neural circuit mechanisms underlying integrating information about reward across time are not fully understood. Here, the authors show that common outcome-integration signals from the medial...

www.nature.com

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Petra Mocellin @petramoce.bsky.social · Mar 27

Don’t miss @handejong.bsky.social latest work at #cosyne2025 this Saturday!

Featuring wireless fiber photometry in a brand new foraging task 🪤 and discounted future value modeling in different accumbens subregions!

Han de Jong @handejong.bsky.social · Mar 27

I’m excited to present a new research project at #cosyne2025 this year!

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Petra Mocellin @petramoce.bsky.social · Mar 27

The latest work from the Lammel lab is out today!

Discover how changes in neurotensin signaling from the NAc Lat to the VTA lead to food devaluation in a mouse model of obesity 🧀🐭

www.nature.com/articles/s41...

Changes in neurotensin signalling drive hedonic devaluation in obesity - Nature

In mice, prolonged consumption of a high-fat diet decreases interest in calorie-rich foods as a result of reduced neurotensin expression and signalling, which uncouples hedonic feeding behaviour linke...

www.nature.com

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Petra Mocellin @petramoce.bsky.social · Mar 6

elifesciences.org/reviewed-pre...

Molecular and spatial transcriptomic classification of midbrain dopamine neurons and their alterations in a LRRK2G2019S model of Parkinson’s disease

elifesciences.org

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Petra Mocellin @petramoce.bsky.social · Feb 15

This looks so so cool, cannot wait to read it! 🤯

“Dopaminergic mechanisms of dynamical social specialization in mouse microsocieties”

www.biorxiv.org/content/10.1...

www.biorxiv.org

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Reposted by Petra Mocellin

Matteo Carandini @carandinilab.net · Feb 7

Neuropixels and Optogenetics are delighted to announce the birth of

Neuropixels Opto

Combining high-resolution electrophysiology and optogenetics

Today in bioRxiv

960 sites, 28 emitters, 2 colors

By Lakunina, @karolinazsocha.bsky.social, Ladd, et al

www.biorxiv.org/content/10.1...

(1/2)

A Neuropixels Opto probe with 3 blue emitters and 3 red emitters lighting up in succession, with corresponding neural activity in different layers of the cortex.

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Petra Mocellin @petramoce.bsky.social · Jan 29

Huge thanks to Drew Kesner for organizing this panel—despite being Bluesky-less! Wishing the NIH situation was different so he could join us. ⛰️

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Petra Mocellin @petramoce.bsky.social · Jan 29

Day 5 at #wcbr2025 – don’t miss our panel!

Join us at 4:30 PM for a session fully dedicated to the medial #septum : inputs, outputs, and role in #motivation & #cognition. 🧠

Excited to share the stage with @smikulovic.bsky.social, @eliftuncozcan.bsky.social, and Dave Bortz. 👩‍🔬👨‍🔬

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Petra Mocellin @petramoce.bsky.social · Jan 27

Day 3 at #wcbr2025 - lots of dopamine, acetylcholine, dorsal and ventral striatum, midbrain circuits and motivated behaviors. Learning so much from such a diverse group of scientists from single dendrite in vivo 2P imaging to high density recordings and modeling 🧠🤯 the field is moving so fast!

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Petra Mocellin @petramoce.bsky.social · Jan 25

Kicked off the first day at #WCBR with an amazing plenary from Suzanne Dickson on #ghrelin, #hunger signaling and its effect on #hypothalamic and #midbrain circuits 🧠

Amazing science in an amazing venue! 🤩

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Petra Mocellin @petramoce.bsky.social · Jan 7

Is #Fluorescence Tuesday a thing?

Still trying to improve the staining protocol, but love this pic of SN #neurons 🔬🧠🐭

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Petra Mocellin @petramoce.bsky.social · Dec 16

Useful resource for 2025 neuro meetings!

The Transmitter @thetransmitter.bsky.social · Nov 20

Still thinking about which neuroscience conferences to attend next year?

Explore our events page, featuring a curated list of top neuroscience meetings with topic-based filters. Plus, check out upcoming webinars compiled by @worldwideneuro.bsky.social.

thetransmitter.org/events

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Petra Mocellin @petramoce.bsky.social · Dec 11

Wow!

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Petra Mocellin @petramoce.bsky.social · Dec 11

Thrilled to share that I’ve been awarded an EMBO postdoctoral fellowship to study nigrostriatal axon regeneration and Parkinson’s disease in the Lammel lab at UC Berkeley 🧠🔬

Grateful for this amazing opportunity and excited to join the EMBO fellows community! 🤩

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Petra Mocellin @petramoce.bsky.social · Dec 6

@norambr.bsky.social !

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Petra Mocellin @petramoce.bsky.social · Dec 3

Congrats Sabine! 🤩

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Petra Mocellin @petramoce.bsky.social · Dec 3

Me 🙋🏻‍♀️

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Petra Mocellin @petramoce.bsky.social · Dec 2

Help #neurosky #neuroskyence

Are you (or do you know) someone studying the transcription factor Ascl4/Mash4? 🧠 #neurodevelopment #differentiation #neurons #wiring

N.b. This is not the same as the acyl CoA synthetase protein ASCL4

I have some questions 💡

Please share! 🙏

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Petra Mocellin @petramoce.bsky.social · Nov 30

Me too 🙋🏻‍♀️

Petra Mocellin @petramoce.bsky.social · Nov 20

3️⃣ Within the GABAergic population, we identified 6 subclusters in the continuum.

These include:
- PV+ and calretinin+ neurons, confirming prior observations
- NPAS1+/Sst+ neurons, which form a distinctive subpopulation
- Nts expressing neurons, adding to the complexity of the GABA population

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Petra Mocellin @petramoce.bsky.social · Nov 20

2️⃣ ChAT-expressing neurons are better described along a transcriptomic continuum with two distinct endpoints:

- one predominantly expresses Galanin, a neuropeptide largely underexplored
-one co-expresses GABAergic machinery, aligning with the previously reported ChAT-GABA co-releasing neurons

3/n

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Petra Mocellin @petramoce.bsky.social · Nov 20

Key findings:

1️⃣ Gad1 and Gad2, traditionally considered specific to GABAergic neurons, also show unexpected expression in ChAT and VGluT2-expressing neurons, challenging established assumptions about neuronal markers in the MSDB.

2/n

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