ironicsans.substack.com/p/60-the-cas...

But 'does he...you know...punt from the Cambridge end' certainly CAN be

Note for those who know neither Oxford nor Cambridge: hard though it is to believe, “they punt from the wrong end” is not, in fact, a euphemism.

cannot really explain to non-Brits how funny it is that this country has artificially developed an entire economy around a triangle of cities in the lowest quarter of the nation and then keeps failing to connect two of those three cities

Kemi Badenoch thinks the Widow's Mite is a cautionary tale about chlamydia

Kemi Badenoch thinks "Caritas" is Boris Johnson's wife

Is there any information on the average amount paid in? Few hundred? Few thousand? What proportion actually go over 12k?

At the very least I’d like to see a validation study done on an anonymised panel of random blood samples of a similar vintage and condition, to verify that it’s not some kind of technical artefact that causes all old samples to look janky when compared to fresh isolates.

Do I believe the PRS finding? Nah. I’m sceptical about them even in high quality extant blood samples, and can quite believe that degraded samples will throw statistically uninterpretable results.

Do I believe the Kallman finding? Probably, depending on the depth of coverage at the locus, the exact nature of the mutation and how that relates to other patients with KS (none of which is information I have).

Without seeing a proper paper I can’t really comment on the accuracy of the finding except to say that I doubt any clinical diagnostic assay has ever been validated for 80 year old dried, degraded blood samples.