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Patrick Murphy

@pjmurphy249.bsky.social

420 followers 280 following 56 posts

Associate Professor @Cornell #Genetics #Epigenetics #Chromatin #Zebrafish #Development #Reproduction #EvoDevo #Bioinformatics #ZGA #StemCells #Regeneration #GoBills #BillsMafia https://blogs.cornell.edu/murphylab/ 🦬🏈💪

blogs.cornell.edu

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Patrick Murphy @pjmurphy249.bsky.social · Feb 5

PREPRINT! Park et al. makes the case that we may be misunderstanding heterochromatin for past 30 years due to ChIP-Seq biases... 1/n

bioRxiv Genomics @biorxiv-genomic.bsky.social · Feb 5

CUT&Tag Identifies Repetitive Genomic Loci that are Excluded from ChIP Assays https://www.biorxiv.org/content/10.1101/2025.02.03.636299v1

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Patrick Murphy @pjmurphy249.bsky.social · 22d

The frig in my basement has a magic gene editing drawer.

Patrick Murphy @pjmurphy249.bsky.social · Aug 21

Big day for the new Cornell version of the Murph lab. Our first gel… woohooo!!!! Science Baby!!!

Reposted by Patrick Murphy

Sara Wickstrom @sarawickstrom.bsky.social · Aug 7

Very happy to see our preprint on how the mechanosensitive ion channel Piezo1 controls intercellular junction maturation by balancing cortex and membrane tension now published in @jcellsci.bsky.social Congratulations to Ahsan & team! journals.biologists.com/jcs/article/...

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Patrick Murphy @pjmurphy249.bsky.social · Jul 17

The “Ins and Outs and What-Abouts” of H2A.Z: A tribute to C. David Allis - Journal of Biological Chemistry www.jbc.org/article/S002...

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Patrick Murphy @pjmurphy249.bsky.social · Jul 11

Check out the new chalk art outside the lab at Cornell!

Patrick Murphy @pjmurphy249.bsky.social · Jul 8

@zebrafishrock.bsky.social could you please broadcast this?

Patrick Murphy @pjmurphy249.bsky.social · Jul 8

Please RT: Published today, a super fun collaboration w/ @fanjumeng.bsky.social and Marnie Halpern's lab to establish methods for transgene mapping in zebrafish - TransTag enables simple and efficient transgene mapping in zebrafish via tagmentation: Cell Reports Methods www.cell.com/cell-reports...

TransTag enables simple and efficient transgene mapping in zebrafish via tagmentation

Meng et al. develop a method called TransTag for simple and efficient mapping of Tol2-based transgenes in zebrafish. TransTag robustly identifies transgene insertion sites and offers an alignment-free...

www.cell.com

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Patrick Murphy @pjmurphy249.bsky.social · Jul 8

TransTag enables simple and efficient transgene mapping in zebrafish via tagmentation: Cell Reports Methods www.cell.com/cell-reports...

TransTag enables simple and efficient transgene mapping in zebrafish via tagmentation

www.cell.com

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Patrick Murphy @pjmurphy249.bsky.social · May 22

Congrats Shan. It was wonderful to participate in the graduation ceremony with you! @urochester.bsky.social

Reposted by Patrick Murphy

marisa-bartolomei.bsky.social @marisa-bartolomei.bsky.social · Apr 30

Great event. Great trainees. Thank you!

Patrick Murphy @pjmurphy249.bsky.social · Apr 29

Such an awesome day! It was wonderful to host Marisa Bartolomei @marisa-bartolomei.bsky.social as the Keynote speaker our annual Genetics Day symposium.

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Patrick Murphy @pjmurphy249.bsky.social · Apr 29

Such an awesome day! It was wonderful to host Marisa Bartolomei @marisa-bartolomei.bsky.social as the Keynote speaker our annual Genetics Day symposium.

Patrick Murphy @pjmurphy249.bsky.social · Apr 5

Congrats!!

IMP @impvienna.bsky.social · Apr 4

🎉Congratulations to our @idajentoft.bsky.social, postdoc in the @pauligroup.bsky.social on being awarded a HFSP fellowship!

The funding will support her research into the molecular mechanisms that regulate translation during embryonic diapause.

More about the project: www.imp.ac.at/news/article...

Patrick Murphy @pjmurphy249.bsky.social · Apr 4

Having an awesome time at the Tri-Repro meeting @pennmedicine.bsky.social @pennepigenetics.bsky.social with my good bud @themodzlab.bsky.social

Reposted by Patrick Murphy

Elizabeth Jacobs, PhD @elizabethjacobs.bsky.social · Mar 28

I had a hypothesis that vitamin D prevents cancer. I worked on this for > 10 years, had 3 NIH-funded grants, and published >30 papers on this topic. Based on our work and that of my esteemed colleagues, I concluded that the evidence does not support the hypothesis.

RFK Jr., we are not the same.

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Patrick Murphy @pjmurphy249.bsky.social · Feb 28

Had a wonderful time visiting the Genetics Department at the University of Georgia. Great food! Great conversation! Great company! and Excellent weather! Thanks for the invite @gollmg.bsky.social

Reposted by Patrick Murphy

lukelukeluke @lukelukeluke.bsky.social · Feb 25

Congratulations to @flashes.blue for their official launch on the App Store 🎉🎉🎉

It’s an instagram alternative built on the AT protocol 🙌 all the visual scrolling with none of the Meta algorithm

A cropped screenshot of the Flashes app in the App Store

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Patrick Murphy @pjmurphy249.bsky.social · Feb 20

Congrats Brandon! So proud of your accomplishments.

Patrick Murphy @pjmurphy249.bsky.social · Feb 12

We all know the story of Henrietta Lacks, but there are countless other examples when biomedical research advanced with a little regard for morals or ethics - often at the expense of poor, disadvantaged, or minority individuals. This book has been enlightening. A good read for current scientists.

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Reposted by Patrick Murphy

@LaBonneLaB @labonnelab.bsky.social · Feb 11

CONGRATS to all!!

Society for Developmental Biology @socdevbio.bsky.social · Feb 11

Congrats to the 2025 SDB Award Winners!
Conklin Medal: Blanche Capel
DB-SDB Lifetime Achievement Award: Billie Swalla
Hamburger Outstanding Educator Prize: Erica Crespi
Hay New Investigator Award: Mubarak Syed
SDB Trainee Science Communication Award: Joaquin Navajas Acedo
bit.ly/4bcrFap

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Reposted by Patrick Murphy

Pradeepa Madapura @pradeepmadapura.bsky.social · Feb 6

Now that I have read this paper, my lab has new findings based on CUT&Tag data that challenge the traditional view of euchromatic and repressive factors. I have started doubting all previous ChIPseq-based conclusions for many targets we are interested in. Thanks for publishing the preprint

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Reposted by Patrick Murphy

bioRxiv Genomics @biorxiv-genomic.bsky.social · Feb 5

CUT&Tag Identifies Repetitive Genomic Loci that are Excluded from ChIP Assays https://www.biorxiv.org/content/10.1101/2025.02.03.636299v1

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Reposted by Patrick Murphy

Pradeepa Madapura @pradeepmadapura.bsky.social · Feb 5

Very interesting another reason to stop doing Chip seq and do cut&tag. Looking forward to reading it

bioRxiv Genomics @biorxiv-genomic.bsky.social · Feb 5

CUT&Tag Identifies Repetitive Genomic Loci that are Excluded from ChIP Assays https://www.biorxiv.org/content/10.1101/2025.02.03.636299v1

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Patrick Murphy @pjmurphy249.bsky.social · Feb 5

Thanks so much Ed!!

Patrick Murphy @pjmurphy249.bsky.social · Feb 5

... Finally, Brandon purified proteins that would otherwise be lost in the pellet in ChIP-Seq, and identified several interesting factors, such as BRD4, NSD2, and RUNX1, (which co-precipitated with repetitive heterochromatin) suggesting these factors might bind and regulate silenced chromatin... 5/5

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Patrick Murphy @pjmurphy249.bsky.social · Feb 5

... Brandon then demonstrated that in situ chromatin fragmentation techniques, like CUT&Tag or CUT&Run, can overcome this problem, allowing him to characterize H3K9me3 enrichment over evolutionarily young repetitive elements.... 4/n