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Plevka Lab @plevkalab.bsky.social · Mar 22

Conference season is back! 🔬🧪

We’re excited to return to Nové Hrady for the XXI Discussions in Structural Molecular Biology by @structbiocssb.bsky.social.

Closing the final session, Pavel Plevka dived into the fascinating world of #enterovirus entry—a great way to wrap up the meeting!

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Plevka Lab @plevkalab.bsky.social · Dec 9

Hi, can our lab be added to the pack? We study interaction of phages with biofilm 🙂

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Plevka Lab @plevkalab.bsky.social · Dec 9

Hi, can our lab be added to the pack? 🙂

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Plevka Lab @plevkalab.bsky.social · Dec 9

Hi, can our lab be added to the pack? 🙂

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Plevka Lab @plevkalab.bsky.social · Dec 9

Hi, can our lab be added to the pack? 🙂

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Plevka Lab @plevkalab.bsky.social · Dec 9

Hello, can you add our lab to the pack? :)

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Plevka Lab @plevkalab.bsky.social · Dec 9

Can you, please, add our lab to the list? 🙂

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Plevka Lab @plevkalab.bsky.social · Dec 9

Can you, please, add our lab to the list?

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Plevka Lab @plevkalab.bsky.social · Dec 9

We would like to be added to the list 🙂

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Plevka Lab @plevkalab.bsky.social · Dec 9

📌

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Plevka Lab @plevkalab.bsky.social · Dec 6

Thank you, Lars! We’re thrilled to join this vibrant community and connect with amazing labs like yours. Looking forward to engaging discussions and collaborations in structural virology!

Reposted by Plevka Lab

Charles University Structural Bioinformatics Group @cusbg.bsky.social · Nov 20

A starter pack with science institutions and research labs in Czech Republic.

Let us know what is missing!

go.bsky.app/Bjam2aQ

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Plevka Lab @plevkalab.bsky.social · Dec 6

❄️ Enjoying the first and, hopefully, not the last snow of this winter ❄️

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Plevka Lab @plevkalab.bsky.social · Dec 6

Stay tuned for more insights into viral entry mechanisms! 🧫
If you liked this #tweetorial, please retweet the first tweet.

bsky.app/profile/plev...

Endosome rupture enables enteroviruses from the family Picornaviridae to infect cells
nature.com/articles/s42...
#CEITECScience
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Plevka Lab @plevkalab.bsky.social · Dec 6

𝗪𝗵𝘆 𝗱𝗼𝗲𝘀 𝘁𝗵𝗶𝘀 𝗺𝗮𝘁𝘁𝗲𝗿?
This study brings us closer to the fundamental understanding of the infection process.
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Plevka Lab @plevkalab.bsky.social · Dec 6

𝗠𝗲𝗺𝗯𝗿𝗮𝗻𝗲 𝘄𝗮𝗿𝗽𝗶𝗻𝗴 𝗮𝗻𝗱 𝗲𝗻𝗱𝗼𝘀𝗼𝗺𝗲 𝗿𝘂𝗽𝘁𝘂𝗿𝗲
Actin filaments observed at membrane protrusions, along with actin polymerisation inhibition results suggest cellular actin can drive endosome rupture.
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Plevka Lab @plevkalab.bsky.social · Dec 6

On the contrary, inhibition of endosome acidification didn’t stop genome-containing particles from exiting the endosomes.
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Plevka Lab @plevkalab.bsky.social · Dec 6

𝗖𝗮𝗻 𝗰𝗲𝗹𝗹𝘂𝗹𝗮𝗿 𝗺𝗲𝗰𝗵𝗮𝗻𝗶𝘀𝗺𝘀 𝗯𝗲 𝗶𝗻𝘃𝗼𝗹𝘃𝗲𝗱? 🦠
Inhibition of the actin polymerisation led to genome release within the endosomes, hindering the virus replication.
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Plevka Lab @plevkalab.bsky.social · Dec 6

𝗛𝗼𝘄 𝗱𝗶𝗱 𝘁𝗵𝗲𝘆 𝗱𝗼 𝗶𝘁?
Using advanced #cryoET at #CEITEC cryoEM facility
to visualise cell entry of rhinovirus 2, echovirus 18, echovirus 30, and enterovirus 71 – right in action! 🔎
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Plevka Lab @plevkalab.bsky.social · Dec 6

𝗞𝗲𝘆 𝗙𝗶𝗻𝗱𝗶𝗻𝗴𝘀
This study reveals that enterovirus-containing #endosomes can deform and rupture, enabling the release of genome-containing particles into the cytoplasm.
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Plevka Lab @plevkalab.bsky.social · Dec 6

#Enteroviruses, members of the Picornaviridae family, cause illnesses ranging from the common cold to encephalitis 😷 However, the infection process was never observed 𝘪𝘯 𝘷𝘪𝘷𝘰 - until now.
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Plevka Lab @plevkalab.bsky.social · Dec 6

✨𝗡𝗘𝗪 𝗣𝗔𝗣𝗘𝗥 𝗔𝗟𝗘𝗥𝗧✨
We are happy to announce that the paper by Aygul Ishemgulova and members of our group, describing the novel mechanism of cell invasion by enteroviruses is now published in @commsbio.bsky.social ! 🦠
Let’s break it down!
🧵
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Plevka Lab @plevkalab.bsky.social · Dec 6

Hello Bluesky!
We're the Plevka Lab, a structural virology research group at CEITEC. Using techniques like SPA #cryo-EM and #cryo-ET 🔬, we explore the fascinating structures of viruses to uncover their secrets. Follow us for research updates, insights, and a glimpse into the world of #virology! 🧫 🦠

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