Dan Polyak
@polym0n.bsky.social
Senior Scientist @Merck | PhD @Brandeis | synthetic chemist | currently loving gardening, exploring nature, looking at birds, crocheting, and petting my cats
Reposted by Dan Polyak
Ok here it is - out of 44 FDA approvals this year, 31 are small molecules (70%), 26 of those are oral drugs (84%), 22 of them are chiral (71%). This is the largest number and percentage of chiral FDA approved molecules in a single year. Fitusiran is not a small molecule, bonus.
December 30, 2025 at 12:56 PM
Ok here it is - out of 44 FDA approvals this year, 31 are small molecules (70%), 26 of those are oral drugs (84%), 22 of them are chiral (71%). This is the largest number and percentage of chiral FDA approved molecules in a single year. Fitusiran is not a small molecule, bonus.
Got a plot at my local community garden and it has been such a pleasant experience. Trying out Square Foot Gardening, not sure how the harvest is going to turn out but at least it looks pretty
May 4, 2025 at 1:29 PM
Got a plot at my local community garden and it has been such a pleasant experience. Trying out Square Foot Gardening, not sure how the harvest is going to turn out but at least it looks pretty
Reposted by Dan Polyak
If you're interested in a break from the doom-and-gloom, may I recommend our article, online today @nature.com
A solution to the pyrazole alkylation problem, leveraging S-to-NR atom replacement. Skeletal editing has strategic value, outside of late-stage!
www.nature.com/articles/s41...
A solution to the pyrazole alkylation problem, leveraging S-to-NR atom replacement. Skeletal editing has strategic value, outside of late-stage!
www.nature.com/articles/s41...
April 3, 2025 at 4:27 PM
If you're interested in a break from the doom-and-gloom, may I recommend our article, online today @nature.com
A solution to the pyrazole alkylation problem, leveraging S-to-NR atom replacement. Skeletal editing has strategic value, outside of late-stage!
www.nature.com/articles/s41...
A solution to the pyrazole alkylation problem, leveraging S-to-NR atom replacement. Skeletal editing has strategic value, outside of late-stage!
www.nature.com/articles/s41...