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Kevin A. Scott

@sculpturatus.bsky.social

1.8K followers 6.2K following 110 posts

Sculpturatus, Inc. Drug Discovery https://scholar.google.com/citations?user=1b6hiCgAAAAJ&hl=en&oi=ao

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Kevin A. Scott @sculpturatus.bsky.social · Nov 25

Excited to see the last of my postdoctoral work at Rockefeller online now! Here we investigate global state-dependent changes in splicing patterns in the context of T cell activation when we inhibit SF3B1 using a covalent small molecule.

www.sciencedirect.com/science/arti...

Covalent targeting of splicing in T cells

Despite significant interest in therapeutic targeting of splicing, few chemical probes are available for the proteins involved in splicing. Here, we s…

www.sciencedirect.com

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Kevin A. Scott @sculpturatus.bsky.social · 9d

Interesting piece in The Lancet

www.thelancet.com/action/showP...

Offline: Those one should not forgive

What was even more shocking than a US President telling pregnant women, “Don’t take Tylenol [paracetamol, acetaminophen], don’t take it…fight like hell not to take it”, was watching the Director of th...

www.thelancet.com

Kevin A. Scott @sculpturatus.bsky.social · Sep 9

If humans had descended from carnivores we wouldn't have ended up with the pharmacopoeia we have today.

Kevin A. Scott @sculpturatus.bsky.social · Sep 6

do any of my chemist friends on here know where i can get a new or used ozonolyzer?

Reposted by Kevin A. Scott

Chemjobber @chemjobber.bsky.social · Sep 4

Anyone from the University of Montreal here? Please DM.

Please RT.

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Kevin A. Scott @sculpturatus.bsky.social · Sep 4

x.com/GovPressOffi...

Governor Newsom Press Office on X: "https://t.co/gh1JgxcrLj" / X

https://t.co/gh1JgxcrLj

x.com

Kevin A. Scott @sculpturatus.bsky.social · Sep 4

weather

Kevin A. Scott @sculpturatus.bsky.social · Sep 2

can you share the recipe???

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Kevin A. Scott @sculpturatus.bsky.social · Sep 2

if anyone has previously used the MISTIC2 web server to do covariation analysis (it's been down for a long time) I wrote my own code to do the same thing. it'll be on gihub eventually but for now you can DM me if you want it. rp if you want

Kevin A. Scott @sculpturatus.bsky.social · Aug 23

👀

Kevin A. Scott @sculpturatus.bsky.social · Aug 11

Needful Things in 4th grade 👀

John Wiswell @wiswell.bsky.social · Aug 11

I really should read Moebius some day.

Kevin A. Scott @sculpturatus.bsky.social · Aug 11

I always thought it would be cool to reconstruct the evolutionary history of natural products like with proteins. While it's likely not possible, I put together a chart of inferred best guesses at when classes of natural products evolved within a greater biological context.

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Kevin A. Scott @sculpturatus.bsky.social · Aug 8

A short video about some of my research.

m.youtube.com/watch?v=QRVB...

Blister Beetles & Cancer: Reengineering nature's toxins as medicine

YouTube video by University of Arizona Health Sciences

m.youtube.com

Kevin A. Scott @sculpturatus.bsky.social · Aug 7

morning

Reposted by Kevin A. Scott

jamelle @jamellebouie.net · Aug 2

one of the single best deals in streaming. i've been paying for PBS Passport for years. it rules

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Reposted by Kevin A. Scott

Chemjobber @chemjobber.bsky.social · Aug 1

Politico has it correct: "Can you ever trust a jobs report again?"

www.politico.com/newsletters/...

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Reposted by Kevin A. Scott

Duncan MacCannell @drm.bsky.social · Aug 1

arstechnica.com/tech-policy/...

RIP Corporation for Public Broadcasting: 1967–2026

NPR: Every community will be hurt by Corporation for Public Broadcasting closing.

arstechnica.com

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Reposted by Kevin A. Scott

Derek Lowe @dereklowe.bsky.social · Jun 10

Vinegar does no good, nor do other acids. Baking soda does no good, nor do other bases.The three tear gases are not neutralized by any of them. Milk does no good either.

You need soap/detergent and water for skin and clothing, and always only plain water for the eyes. Lots of it.

That’s it.

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Reposted by Kevin A. Scott

Matt Wall @mattwall.bsky.social · Jun 10

Whoa. You can do that?!

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Reposted by Kevin A. Scott

McSweeney's @mcsweeneys.net · Jun 8

Lots of talk today about the demise of BlueSky. For whatever it's worth, it's been a boon to indie publishers like us. Twitter and Facebook have pretty much silenced us, so the engagement here has, and continues to be, wonderful.

410 1.8K 16K

Reposted by Kevin A. Scott

Eric Topol @erictopol.bsky.social · Jun 5

He's right. "Nothing short of devastating"
By @holdenthorp.bsky.social @science.org
www.science.org/doi/10.1126/...

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Kevin A. Scott @sculpturatus.bsky.social · Jun 5

i have to dry and purify mCPBA (i know, i know...) and this is how much water is in ten grams of the commercially available 70% stuff.

Kevin A. Scott @sculpturatus.bsky.social · Jun 4

oh, we miss this lawn

Kevin A. Scott @sculpturatus.bsky.social · Jun 2

Many plants produce toxins to deter herbivores. Over time, herbivores evolved ways to detoxify them. Carnivores didn’t need to—meat lacks such toxins. Humans are omnivores descended from herbivores; dogs are omnivores descended from carnivores. That’s why some foods safe for us are toxic to dogs.

Kevin A. Scott @sculpturatus.bsky.social · Jun 1

what have you done in the name of science?

as an undergrad i was doing a work up at 10 PM on a saturday night when we ran out of dry ice. i rode my bike in the rain to the grocery store, open til midnight, who has a butcher and bought 5 lb of dry ice for the rotovap

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Kevin A. Scott @sculpturatus.bsky.social · May 30

i shared this news story with my friends saying that the Lehrer tune finally came true. "Good ol american know how. that's what."