Anubhav Prakash
@prakash-patterns.bsky.social
Some sort of experimental biologist interested in shapes and patterns. Postdoc @mpi-muenster; earlier @ashoka university. Once a grad student @NCBS Bangalore
Pinned
How does the #cochlea achieve its spiral shape? @prakash-patterns.bsky.social @earlab.bsky.social &co show that the expression of adhesion & polarity proteins pattern the #OrganOfCorti and drive the compartment-specific organisation to achieve the cochlea spiral @plosbiology.org 🧪 plos.io/4nmD8IW
We show the Organ of Corti is composed of adhesion-molecule based compartments and the interaction between these compartments (compartment coupling) drives pattern and polarity. This seems like a fundamental design principle of developing tissues.
Bhaval discusses our work to give an exploratory view on the forces driving epithelial diversity. Check it out!
From uniform beginnings, junctional heterogeneity and cell-specific mechanics choreograph the stunning diversity of sensory epithelia.
Bhaval Parmar discusses recent work from Anubhav Prakash @prakash-patterns.bsky.social & colleagues. #DevBio
#preLight ⬇️
prelights.biologists.com/highlights/j...
Bhaval Parmar discusses recent work from Anubhav Prakash @prakash-patterns.bsky.social & colleagues. #DevBio
#preLight ⬇️
prelights.biologists.com/highlights/j...
Junctional Heterogeneity Shapes Epithelial Morphospace - preLights
From uniform beginnings, junctional heterogeneity and cell-specific mechanics choreograph the stunning diversity of sensory epithelia.
prelights.biologists.com
January 5, 2026 at 2:56 PM
Bhaval discusses our work to give an exploratory view on the forces driving epithelial diversity. Check it out!
This image here shows a 3D-rendered cristae from the mouse's inner ear. In red ♥️ is F-actin marking cell junctions and the 💙 is beta-Spectrin 2 marking the mechano-sensory hair cells. These are important for the sense of balance and linear acceleration.
November 27, 2025 at 4:05 PM
This image here shows a 3D-rendered cristae from the mouse's inner ear. In red ♥️ is F-actin marking cell junctions and the 💙 is beta-Spectrin 2 marking the mechano-sensory hair cells. These are important for the sense of balance and linear acceleration.
Reposted by Anubhav Prakash
Boris Shraiman points a physicist’s eye on biological quandaries news.ucsb.edu/2025/022264/... 🧪
Boris Shraiman points a physicist’s eye on biological quandaries
Boris Shraiman is awarded the American Physical Society’s Max Delbrück Prize in Biological Physics.
news.ucsb.edu
November 25, 2025 at 7:38 PM
Boris Shraiman points a physicist’s eye on biological quandaries news.ucsb.edu/2025/022264/... 🧪
My favourite gene, Vangl2 in action
On how Vangl2 shapes the heart❤️
Planar cell polarity protein, Vangl2, goes out of its way to shape the heart through a planar polarity-independent mechanism. #preprint from the team of @meilhacsigolene.bsky.social
#preLight by @prakash-patterns.bsky.social⬇️
prelights.biologists.com/highlights/v...
Planar cell polarity protein, Vangl2, goes out of its way to shape the heart through a planar polarity-independent mechanism. #preprint from the team of @meilhacsigolene.bsky.social
#preLight by @prakash-patterns.bsky.social⬇️
prelights.biologists.com/highlights/v...
VANGL2 shapes the mouse heart tube from adjacent epithelia and without planar polarity - preLights
Planar cell polarity protein, Vangl2, goes out of its way to shape the heart through a planar polarity-independent mechanism.
prelights.biologists.com
November 20, 2025 at 12:56 PM
My favourite gene, Vangl2 in action
Reposted by Anubhav Prakash
Excited to embark on this scientific journey with Ewa Paluch and Daniel StJohnston to understand fundamentals of epithelial tissue and cell shapes! Thank you to @erc.europa.eu for the support!
🚀 Exciting news! ERC Synergy Grant of €8.5 million to Sara Wickström @sarawickstrom.bsky.social, Daniel St Jonston @gurdoninstitute.bsky.social and Ewa Paluch @universitypress.cambridge.org! This highly interdisciplinary project will boost our understanding of tissue biology. #ERCSyG @erc.europa.eu
November 6, 2025 at 12:14 PM
Excited to embark on this scientific journey with Ewa Paluch and Daniel StJohnston to understand fundamentals of epithelial tissue and cell shapes! Thank you to @erc.europa.eu for the support!
Ever wondered how tissues have diverse organisations? We did with some experiments on sensory epithelia of 🐣 🐟 and 🐁. We found that these epithelia are initially very similar. As they develop, cell types acquire a solid/fluid-like mechanical state driving the cellular organisation. Comments welcome!
Junctional Heterogeneity Shapes Epithelial Morphospace https://www.biorxiv.org/content/10.1101/2025.11.03.686357v1
November 5, 2025 at 10:22 PM
Ever wondered how tissues have diverse organisations? We did with some experiments on sensory epithelia of 🐣 🐟 and 🐁. We found that these epithelia are initially very similar. As they develop, cell types acquire a solid/fluid-like mechanical state driving the cellular organisation. Comments welcome!
Reposted by Anubhav Prakash
#authorinterview Anubhav Prakash @prakash-patterns.bsky.social from Prof Raj Ladher lab earlab.bsky.social at NCBS, Bangalore talks about his work on "Kompartment Konnection: How the Cochlea Coordinates for a Perfect Design" PLOS Biology biopatrika.com/academia/res... @ncbsbangalore.bsky.social
Kompartment Konnection: How the Cochlea Coordinates for a Perfect Design - BioPatrika
Researcher Spotlight - Uncover how compartments integrate spatial and temporal cues across scales & how local cellular behaviours influence
biopatrika.com
October 16, 2025 at 6:09 AM
#authorinterview Anubhav Prakash @prakash-patterns.bsky.social from Prof Raj Ladher lab earlab.bsky.social at NCBS, Bangalore talks about his work on "Kompartment Konnection: How the Cochlea Coordinates for a Perfect Design" PLOS Biology biopatrika.com/academia/res... @ncbsbangalore.bsky.social
link.growkudos.com/1efpeb7d8n4 A short article is now available at Kudos on our work @earlab.bsky.social at @ncbsbangalore.bsky.social about how the cochlea generates its pattern.
Cochlea generates patterns by interacting with neighbours
We wanted to understand how cells arrange into precise patterns as the cochlea develops its spiral shape. We found that the cochlea is divided into smaller domains, each organising independently whil...
link.growkudos.com
September 30, 2025 at 1:43 PM
link.growkudos.com/1efpeb7d8n4 A short article is now available at Kudos on our work @earlab.bsky.social at @ncbsbangalore.bsky.social about how the cochlea generates its pattern.
The ear's organ of Corti as a model system of how developmental instructions coordinate across spatial scales so that tissues are sculpted reproducibly
📷 @prakash-patterns.bsky.social et al @tifr.res.in in @plosbiology.org
➡️ bpod.org.uk/archive/2025...
📷 @prakash-patterns.bsky.social et al @tifr.res.in in @plosbiology.org
➡️ bpod.org.uk/archive/2025...
September 17, 2025 at 5:29 PM
Reposted by Anubhav Prakash
My lab @mpi-muenster.bsky.social is looking for a computational biologist with a passion for imaging and spatial biology. A staff scientist position with long-term perspective! Apply and spread the word 🙏 jobs.mpi-muenster.mpg.de/jobposting/0...
Computational image analyst (m/f/d)
The Max Planck Institute for Molecular Biomedicine in Münster, Germany, has an opening for a
jobs.mpi-muenster.mpg.de
September 12, 2025 at 6:17 AM
My lab @mpi-muenster.bsky.social is looking for a computational biologist with a passion for imaging and spatial biology. A staff scientist position with long-term perspective! Apply and spread the word 🙏 jobs.mpi-muenster.mpg.de/jobposting/0...
Editor's insightful commentary on our work in cochlear morphogenesis.
#Morphogens cooperate to guide development of the #cochlea. This Primer explores a @plosbiology.org study showing how #PlanarCellPolarity of individual cells is integrated across distinct regional compartments to ensure proper organ #morphogenesis. Paper: plos.io/4nmD8IW Primer: plos.io/3IjPkLR
September 11, 2025 at 9:55 AM
Editor's insightful commentary on our work in cochlear morphogenesis.
Reposted by Anubhav Prakash
Our September issue is online! www.embopress.org/toc/17574684...
On the cover: AAV-mediated delivery of Clic5 restores inner ear structure & function in a model of hereditary hearing and balance loss 👉 doi.org/10.1038/s443...
Scientific image: R. Hahn & K. Avraham, at Tel Aviv University
On the cover: AAV-mediated delivery of Clic5 restores inner ear structure & function in a model of hereditary hearing and balance loss 👉 doi.org/10.1038/s443...
Scientific image: R. Hahn & K. Avraham, at Tel Aviv University
EMBO Molecular Medicine: Vol 17, No 9
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
www.embopress.org
September 11, 2025 at 8:35 AM
Our September issue is online! www.embopress.org/toc/17574684...
On the cover: AAV-mediated delivery of Clic5 restores inner ear structure & function in a model of hereditary hearing and balance loss 👉 doi.org/10.1038/s443...
Scientific image: R. Hahn & K. Avraham, at Tel Aviv University
On the cover: AAV-mediated delivery of Clic5 restores inner ear structure & function in a model of hereditary hearing and balance loss 👉 doi.org/10.1038/s443...
Scientific image: R. Hahn & K. Avraham, at Tel Aviv University
We show the Organ of Corti is composed of adhesion-molecule based compartments and the interaction between these compartments (compartment coupling) drives pattern and polarity. This seems like a fundamental design principle of developing tissues.
How does the #cochlea achieve its spiral shape? @prakash-patterns.bsky.social @earlab.bsky.social &co show that the expression of adhesion & polarity proteins pattern the #OrganOfCorti and drive the compartment-specific organisation to achieve the cochlea spiral @plosbiology.org 🧪 plos.io/4nmD8IW
September 10, 2025 at 1:20 PM
We show the Organ of Corti is composed of adhesion-molecule based compartments and the interaction between these compartments (compartment coupling) drives pattern and polarity. This seems like a fundamental design principle of developing tissues.
Reposted by Anubhav Prakash
#LatestPublication
In a latest study published in PLOS Genetics, Ramankaushik and team from Dr Raj Ladher's lab describe a new role for protocadherin-15 in patterning the hair cell.
🎉Congratulations to the team!
journals.plos.org/plosgenetics...
In a latest study published in PLOS Genetics, Ramankaushik and team from Dr Raj Ladher's lab describe a new role for protocadherin-15 in patterning the hair cell.
🎉Congratulations to the team!
journals.plos.org/plosgenetics...
Role of Pcdh15 in the development of intrinsic polarity of inner ear hair cells
Author summary Hearing, like other sensory modalities, is essential for animals to perceive and interact with their environment. The cochlea, the auditory sensory organ, develops under tight genetic r...
journals.plos.org
August 19, 2025 at 11:07 AM
#LatestPublication
In a latest study published in PLOS Genetics, Ramankaushik and team from Dr Raj Ladher's lab describe a new role for protocadherin-15 in patterning the hair cell.
🎉Congratulations to the team!
journals.plos.org/plosgenetics...
In a latest study published in PLOS Genetics, Ramankaushik and team from Dr Raj Ladher's lab describe a new role for protocadherin-15 in patterning the hair cell.
🎉Congratulations to the team!
journals.plos.org/plosgenetics...
preprint: Using a combination of experiments and theory, we show that force patterning at apical junctions drives three-dimensional spatial organisation in multi-cell-type epithelia. Give us your comments!
Force patterning drives cell flows and 3D spatial order in auditory epithelia https://www.biorxiv.org/content/10.1101/2025.06.26.661757v1
June 29, 2025 at 11:26 AM
preprint: Using a combination of experiments and theory, we show that force patterning at apical junctions drives three-dimensional spatial organisation in multi-cell-type epithelia. Give us your comments!
Reposted by Anubhav Prakash
#authorinterview Anubhav Prakash @prakash-patterns.bsky.social from Prof Raj Ladher lab @earlab.bsky.social, NCBS @ncbsbangalore.bsky.social talks about his work on "Pushing and pulling cells from chaos to order" biopatrika.com/academia/res... @natcomms.nature.com
Pushing and pulling cells from chaos to order - BioPatrika
Researcher Spotlight - Pulling cells: Using a combination of experiments and mathematical modelling, we show that the tuned differences in the mechanical properties of junctions can organise cells int...
biopatrika.com
June 4, 2025 at 4:18 AM
#authorinterview Anubhav Prakash @prakash-patterns.bsky.social from Prof Raj Ladher lab @earlab.bsky.social, NCBS @ncbsbangalore.bsky.social talks about his work on "Pushing and pulling cells from chaos to order" biopatrika.com/academia/res... @natcomms.nature.com
Reposted by Anubhav Prakash
#LatestPublication in @natcomms.nature.com by
Dr Raj Ladher & team show that fine-tuned junctional mechanics are vital for aligning polarity in chicken cochlea.
🎉Congratulations to the team!
@prakash-patterns.bsky.social @earlab.bsky.social
Read here: www.nature.com/articles/s41...
Dr Raj Ladher & team show that fine-tuned junctional mechanics are vital for aligning polarity in chicken cochlea.
🎉Congratulations to the team!
@prakash-patterns.bsky.social @earlab.bsky.social
Read here: www.nature.com/articles/s41...
Junctional force patterning drives both positional order and planar polarity in the auditory epithelia - Nature Communications
Sound is sensed in the cochlea through a precisely organised epithelium. Prakash and colleagues show cellular organisation results from differences in junction contractility, finding mechanics is suff...
www.nature.com
April 30, 2025 at 6:22 AM
#LatestPublication in @natcomms.nature.com by
Dr Raj Ladher & team show that fine-tuned junctional mechanics are vital for aligning polarity in chicken cochlea.
🎉Congratulations to the team!
@prakash-patterns.bsky.social @earlab.bsky.social
Read here: www.nature.com/articles/s41...
Dr Raj Ladher & team show that fine-tuned junctional mechanics are vital for aligning polarity in chicken cochlea.
🎉Congratulations to the team!
@prakash-patterns.bsky.social @earlab.bsky.social
Read here: www.nature.com/articles/s41...
My PhD work on the development of spatial organisation and planar polarity in avian auditory epithelia is now published @natcomms.nature.com doi.org/10.1038/s414...
Junctional force patterning drives both positional order and planar polarity in the auditory epithelia - Nature Communications
Sound is sensed in the cochlea through a precisely organised epithelium. Prakash and colleagues show cellular organisation results from differences in junction contractility, finding mechanics is suff...
doi.org
April 29, 2025 at 6:40 PM
My PhD work on the development of spatial organisation and planar polarity in avian auditory epithelia is now published @natcomms.nature.com doi.org/10.1038/s414...