Miki Ebisuya, TU Dresden EMBL
Mukund Thattai, NCBS
Nicoletta Petridou, EMBL
Paul François, McGill
Rashmi Priya, Crick
Sara Wickström, MPI
Takashi Hiiragi, Hubrecht Institute
Wendell Lim, UCSF
Yanlan Mao, MRC

Jennifer A. Lewis, Harvard
Jesse Veenvliet, MPI
Jun Allard, UCI
Karen Alim, MPI
L. (Maha) Mahadevan, Harvard
Matthias Lutolf, EPFL
Michael Elowitz, Caltech
Miguel L. Concha, Universidad de Chile

Still some doubts 😊here the list of speakers
Alan Lowe, CZI
Alex Schier, Biozentrum
Allon Klein, Harvard
Amy Shyer, The Rockefeller
Arthur Lander, UCI
Christina Theodoris, Gladstone
Dana Pe’er, MSKCC
Ewa Paluch, Cambridge
Giovanni D’Angelo, EPFL
James Briscoe, Crick

The deadline to apply for the Lake Conference on Modeling Life from Cells to Tissues is just few weeks away!

Apply to attend by December 12:
alleninstitute.org/events/aics-...

Modeling Life from Cells to Tissues

This shows that transient heterogeneity establishes a regulatory framework essential for proper intestinal regeneration and could be a general principle underlying a wide range of regenerative processes.

And validated in vivo!

We developed mathematical models showing how YAP1 and FOXA1 drive bistable states, allowing cells to "lock in" their fates. A feedback loop ensures long-term pattern stability and confers memory to the system.

And FOXA1 role is essential to exit a default state of differentiation.

YAP1 heterogeneity primes secretory progenitor cells, setting the stage for robust patterning. This involves chromatin remodelling, creating a favourable environment for FOXA1, a critical transcription factor.

When tissue density hits a critical level, YAP1 activity becomes heterogeneously inactivated. This cell-to-cell variability is essential for triggering the first cell fate decisions via chromatic remodelling and Delta-Notch signalling.

And the movie!

We also made a Yap activity fluorescent reporter organoid line to look into the dynamics at the tissue scales!

Using in vitro organoids and in vivo mouse models, we uncovered that mechanosensor YAP1 acts as a molecular "pre-patterner" cue during regeneration.

Amazing work @cschwayer.bsky.social @silviabarbiero.bsky.social @davidbrueckner.bsky.social @ehannezo.bsky.social