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Reposted by Prisca Liberali

paveltomancak.bsky.social @paveltomancak.bsky.social · Aug 21

The last day of lectures at #LISH25 starts with Gustavo Medeiros presenting applications of light sheet microscopy to #organoid research. @priscaliberali.bsky.social lab. Gustavo is a physicist and a creative artist and the walk-up song delivers that message. Video in thread.

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FMI science @fmiscience.bsky.social · Jun 11

🚨We're hiring! Join a global team at the @priscaliberali.bsky.social lab & the @alleninstitute.org to build cutting-edge image analysis workflows for complex biological datasets, including light-sheet microscopy images. Apply at: www.fmi.ch/education-ca...

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FMI science @fmiscience.bsky.social · Jun 12

We're seeking a Research Associate in stem cell biology to join a global, interdisciplinary team investigating organoids and tissue organization. This unique role is part of a collaboration between the @priscaliberali.bsky.social lab & the @alleninstitute.org. Apply at: www.fmi.ch/education-ca...

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FMI science @fmiscience.bsky.social · Mar 25

In @naturephysics.bsky.social, researchers from @priscaliberali.bsky.social's lab and @ehannezo.bsky.social's group reveal how intestinal organoids form crypts, key to gut regeneration and stability. Their work could impact tissue engineering and regenerative medicine. www.fmi.ch/news-events/...

Shaping the gut: how tissue mechanics drives intestinal organoids formation

FMI researchers have shed light on how intestinal organoids form crypts, the pockets that house stem cells for gut regeneration and long-term stability. Their findings may have broader implications fo...

www.fmi.ch

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Prisca Liberali @priscaliberali.bsky.social · Mar 20

Amazing work Irene and Tomo!

Irene Miguel-Aliaga @irenemiguel-aliaga.bsky.social · Mar 19

Epic effort led by Tomo Ameku in the lab, with contributions from the labs of Nick Bellono, Vassilis Pachnis, @francoisleulier.bsky.social, @schwarzergnoto.bsky.social, @priscaliberali.bsky.social, ‪@coxlabkcl.bsky.social,‬ @priscaliberali.bsky.social and Maria Rodriguez-Colman

Irene Miguel-Aliaga @irenemiguel-aliaga.bsky.social · Mar 19

Lab’s latest: (mouse) mums grow their guts during pregnancy and lactation: www.cell.com/cell/fulltex...

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Prisca Liberali @priscaliberali.bsky.social · Mar 12

Super retreat! And don’t miss the paper on robustness in crypt morphogenesis 🤩

Edouard Hannezo @ehannezo.bsky.social · Mar 10

Fun group retreat in the Austrian alps with @priscaliberali.bsky.social! And perfect time to celebrate our new joint paper (from Shi-Lei Xue & Qiutan Yang) out on how mechanochemical bistability confers robustness to intestinal organoids! www.nature.com/articles/s41... - see 🧵! (1/n)

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Edouard Hannezo @ehannezo.bsky.social · Mar 10

Fun group retreat in the Austrian alps with @priscaliberali.bsky.social! And perfect time to celebrate our new joint paper (from Shi-Lei Xue & Qiutan Yang) out on how mechanochemical bistability confers robustness to intestinal organoids! www.nature.com/articles/s41... - see 🧵! (1/n)

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Prisca Liberali @priscaliberali.bsky.social · Feb 1

Don’t forget to apply! This is an amazing opportunity!

FMI science @fmiscience.bsky.social · Dec 16

📣 Please share: We’re hiring a tenure-track Group Leader in Multicellular Systems to explore the molecular and cellular mechanisms driving the formation, maintenance, or destabilization of tissues, organs and organisms. Apply at: www.fmi.ch/education-ca...

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Prisca Liberali @priscaliberali.bsky.social · Jan 15

This shows that transient heterogeneity establishes a regulatory framework essential for proper intestinal regeneration and could be a general principle underlying a wide range of regenerative processes.

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Prisca Liberali @priscaliberali.bsky.social · Jan 15

And validated in vivo!

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Prisca Liberali @priscaliberali.bsky.social · Jan 15

We developed mathematical models showing how YAP1 and FOXA1 drive bistable states, allowing cells to "lock in" their fates. A feedback loop ensures long-term pattern stability and confers memory to the system.

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Prisca Liberali @priscaliberali.bsky.social · Jan 15

And FOXA1 role is essential to exit a default state of differentiation.

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Prisca Liberali @priscaliberali.bsky.social · Jan 15

YAP1 heterogeneity primes secretory progenitor cells, setting the stage for robust patterning. This involves chromatin remodelling, creating a favourable environment for FOXA1, a critical transcription factor.

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Prisca Liberali @priscaliberali.bsky.social · Jan 15

When tissue density hits a critical level, YAP1 activity becomes heterogeneously inactivated. This cell-to-cell variability is essential for triggering the first cell fate decisions via chromatic remodelling and Delta-Notch signalling.

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Prisca Liberali @priscaliberali.bsky.social · Jan 15

And the movie!

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Prisca Liberali @priscaliberali.bsky.social · Jan 15

We also made a Yap activity fluorescent reporter organoid line to look into the dynamics at the tissue scales!

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Prisca Liberali @priscaliberali.bsky.social · Jan 15

Using in vitro organoids and in vivo mouse models, we uncovered that mechanosensor YAP1 acts as a molecular "pre-patterner" cue during regeneration.

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Prisca Liberali @priscaliberali.bsky.social · Jan 15

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Prisca Liberali @priscaliberali.bsky.social · Jan 15

Amazing work @cschwayer.bsky.social @silviabarbiero.bsky.social @davidbrueckner.bsky.social @ehannezo.bsky.social

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Prisca Liberali @priscaliberali.bsky.social · Jan 15

Tissue regeneration is driven by cells transitioning from homogenous regenerative cells to a patterned crypt. But actually cell-to-cell variability plays a super important role for the return to homeostasis!

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Prisca Liberali @priscaliberali.bsky.social · Jan 15

A perfect start in the new year! 🌱 Regenerating tissues are just an amazing spatio temporal controlled process! Our new manuscript explores how cell heterogeneity and bistability orchestrate intestinal regeneration. 🧵 biorxiv.org/cgi/content/...

Cell heterogeneity and fate bistability drive tissue patterning during intestinal regeneration

Tissue regeneration relies on the ability of cells to undergo de novo patterning. While tissue patterning has been viewed as the transition from initially identical un-patterned cells to an arrangemen...

biorxiv.org

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Luca Giorgetti lab @FMI @lucagiorgetti.bsky.social · Dec 16

Join us at FMI as a Junior Group Leader! A unique opportunity to set up your lab in a vibrant international research institute with world-class research groups and facilities, generous core funding, a collegial and inclusive culture - and great colleagues 🤓!

FMI science @fmiscience.bsky.social · Dec 16

📣 Please share: We’re hiring a tenure-track Group Leader in Multicellular Systems to explore the molecular and cellular mechanisms driving the formation, maintenance, or destabilization of tissues, organs and organisms. Apply at: www.fmi.ch/education-ca...

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Prisca Liberali @priscaliberali.bsky.social · Dec 16

We have a new opening! Amazing environment colleagues and facility! Join us!

FMI science @fmiscience.bsky.social · Dec 16

📣 Please share: We’re hiring a tenure-track Group Leader in Multicellular Systems to explore the molecular and cellular mechanisms driving the formation, maintenance, or destabilization of tissues, organs and organisms. Apply at: www.fmi.ch/education-ca...

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Prisca Liberali @priscaliberali.bsky.social · Dec 15

Do you want to know how tissue is coordinated across space and time? Don’t miss Laura’s talk!

lauracapolupo.bsky.social @lauracapolupo.bsky.social · Dec 15

If you are attending #CellBio2024 and are interested in understanding how the process of crypt morphogenesis is coordinated both in vivo and in organoids then come to my talk Wed Dec 18th in the subgroup “Organoids as tools to study the function of tissue in Health and Disease”

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Prisca Liberali @priscaliberali.bsky.social · Dec 15

Don’t miss Conny’s talk!!

Cornelia Schwayer @cschwayer.bsky.social · Dec 14

Have you ever wondered how cell heterogeneity can regulate tissue patterning and how such patterns are maintained? Then come to my talk at the ASCB meeting #cellbio2024 this Sunday afternoon ☺️

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