prot_papers
@protpapers.bsky.social
🤖 Feed for papers about HLA/MHC neoantigens, immunopeptidomes and HDX-MS from PubMed and bioRxiv. Run by @ab604.uk inspired by @phypapers.bsky.social and https://bsky.app/profile/r-bloggers.bsky.social. Code: https://github.com/ab604/prot-paper-bot
Control of antigen presentation on MHC-I by a bacterial secretion system https://pubmed.ncbi.nlm.nih.gov/41332634/
December 3, 2025 at 5:42 PM
Control of antigen presentation on MHC-I by a bacterial secretion system https://pubmed.ncbi.nlm.nih.gov/41332634/
Cancers modulate p53 truncal neoantigen display to evade T cell detection
https://www.biorxiv.org/content/10.1101/2025.11.26.690562v1
December 1, 2025 at 5:46 AM
Cancers modulate p53 truncal neoantigen display to evade T cell detection
https://www.biorxiv.org/content/10.1101/2025.11.26.690562v1
A microenvironment-driven HLA-II-associated insulin neoantigen elicits persistent memory T cell activation in diabetes https://pubmed.ncbi.nlm.nih.gov/41315082/
November 30, 2025 at 5:39 AM
A microenvironment-driven HLA-II-associated insulin neoantigen elicits persistent memory T cell activation in diabetes https://pubmed.ncbi.nlm.nih.gov/41315082/
Structural mechanisms of allosteric regulation in the human cis-prenyltransferase complex https://pubmed.ncbi.nlm.nih.gov/41315348/
November 29, 2025 at 5:34 PM
Structural mechanisms of allosteric regulation in the human cis-prenyltransferase complex https://pubmed.ncbi.nlm.nih.gov/41315348/
Using hydrogen/deuterium exchange mass spectrometry to understand bacterial membrane efflux proteins https://pubmed.ncbi.nlm.nih.gov/41309178/
November 28, 2025 at 5:41 AM
Using hydrogen/deuterium exchange mass spectrometry to understand bacterial membrane efflux proteins https://pubmed.ncbi.nlm.nih.gov/41309178/
Immunopeptidomics Workflow for Isolation and LC-MS/MS Analysis of MHC Class I-Bound Peptides Under Hypoxic Conditions https://pubmed.ncbi.nlm.nih.gov/41306581/
November 27, 2025 at 5:35 PM
Immunopeptidomics Workflow for Isolation and LC-MS/MS Analysis of MHC Class I-Bound Peptides Under Hypoxic Conditions https://pubmed.ncbi.nlm.nih.gov/41306581/
A Globally Representative Immunopeptidomics Approach to Identify Population-Wide Vaccine Candidates
https://www.biorxiv.org/content/10.1101/2025.11.25.690604v1
November 27, 2025 at 5:41 AM
A Globally Representative Immunopeptidomics Approach to Identify Population-Wide Vaccine Candidates
https://www.biorxiv.org/content/10.1101/2025.11.25.690604v1
Rewiring tumor visibility: The immunopeptidome as a dynamic interface between antigen processing, microenvironmental stress, and immune recognition https://pubmed.ncbi.nlm.nih.gov/41293269/
November 26, 2025 at 5:38 PM
Rewiring tumor visibility: The immunopeptidome as a dynamic interface between antigen processing, microenvironmental stress, and immune recognition https://pubmed.ncbi.nlm.nih.gov/41293269/
Major histocompatibility complex class II-expressing bone marrow megakaryocytes activate CD4+ T cells and induce regulatory T cell fate
https://www.biorxiv.org/content/10.1101/2025.11.21.689743v1
November 23, 2025 at 5:38 AM
Major histocompatibility complex class II-expressing bone marrow megakaryocytes activate CD4+ T cells and induce regulatory T cell fate
https://www.biorxiv.org/content/10.1101/2025.11.21.689743v1
Decrypting cellular engagement and recruitment from spatially resolved transcriptomics
https://www.biorxiv.org/content/10.1101/2025.11.20.689581v1
November 21, 2025 at 5:36 PM
Decrypting cellular engagement and recruitment from spatially resolved transcriptomics
https://www.biorxiv.org/content/10.1101/2025.11.20.689581v1
Control of antigen presentation on MHC-I by a bacterial secretion system
https://www.biorxiv.org/content/10.1101/2025.11.19.689332v1
November 20, 2025 at 5:35 PM
Control of antigen presentation on MHC-I by a bacterial secretion system
https://www.biorxiv.org/content/10.1101/2025.11.19.689332v1
Crowding does not suppress the opening of a cryptic pocket
https://www.biorxiv.org/content/10.1101/2025.11.17.688865v1
November 19, 2025 at 5:40 AM
Crowding does not suppress the opening of a cryptic pocket
https://www.biorxiv.org/content/10.1101/2025.11.17.688865v1
Discovery of an orally available potent ER aminopeptidase 1 (ERAP1) inhibitor that enhances anti-tumor responses and limits inflammatory autoimmunity in vivo.
https://www.biorxiv.org/content/10.1101/2025.11.17.686761v1
November 18, 2025 at 5:38 PM
Discovery of an orally available potent ER aminopeptidase 1 (ERAP1) inhibitor that enhances anti-tumor responses and limits inflammatory autoimmunity in vivo.
https://www.biorxiv.org/content/10.1101/2025.11.17.686761v1
Distinct Mechanisms for Inhibition of SARS-CoV-2 Main Protease: Dimerization Promoted by Peptidomimetic Inhibitors and Disrupted by Ebselen
https://www.biorxiv.org/content/10.1101/2025.11.16.688752v1
November 18, 2025 at 5:40 AM
Distinct Mechanisms for Inhibition of SARS-CoV-2 Main Protease: Dimerization Promoted by Peptidomimetic Inhibitors and Disrupted by Ebselen
https://www.biorxiv.org/content/10.1101/2025.11.16.688752v1
Dynamics and structural features of the eEF1A1 and eEF1A2 paralogs https://pubmed.ncbi.nlm.nih.gov/41242523/
November 17, 2025 at 5:41 AM
Dynamics and structural features of the eEF1A1 and eEF1A2 paralogs https://pubmed.ncbi.nlm.nih.gov/41242523/
Spatially Resolved Determination of Small Molecule Protein Affinities by Hydrogen Deuterium Exchange Mass Spectrometry
https://www.biorxiv.org/content/10.1101/2025.11.13.688232v1
November 14, 2025 at 5:39 AM
Spatially Resolved Determination of Small Molecule Protein Affinities by Hydrogen Deuterium Exchange Mass Spectrometry
https://www.biorxiv.org/content/10.1101/2025.11.13.688232v1
Antigenic Dark Matter: Unexplored Post-Translational Modifications of Tumor-Associated and Tumor-Specific Antigens in Pancreatic Cancer https://pubmed.ncbi.nlm.nih.gov/41228299/
November 13, 2025 at 5:40 PM
Antigenic Dark Matter: Unexplored Post-Translational Modifications of Tumor-Associated and Tumor-Specific Antigens in Pancreatic Cancer https://pubmed.ncbi.nlm.nih.gov/41228299/
NeoAtlas-Tumor and NeoBert: A Database and A Predictive Model for Canonical and Noncanonical Tumor Neoantigens https://pubmed.ncbi.nlm.nih.gov/41224698/
November 13, 2025 at 5:42 AM
NeoAtlas-Tumor and NeoBert: A Database and A Predictive Model for Canonical and Noncanonical Tumor Neoantigens https://pubmed.ncbi.nlm.nih.gov/41224698/
Inferring residue level hydrogen deuterium exchange with ReX https://pubmed.ncbi.nlm.nih.gov/41214241/
November 11, 2025 at 5:39 AM
Inferring residue level hydrogen deuterium exchange with ReX https://pubmed.ncbi.nlm.nih.gov/41214241/
Immunolyser 2.0: An advanced computational pipeline for comprehensive analysis of immunopeptidomic data https://pubmed.ncbi.nlm.nih.gov/41209766/
November 10, 2025 at 5:38 PM
Immunolyser 2.0: An advanced computational pipeline for comprehensive analysis of immunopeptidomic data https://pubmed.ncbi.nlm.nih.gov/41209766/
Non-Enzymatic Structural Modifications Reshape Peptide Presentation and Antigen Recognition
https://www.biorxiv.org/content/10.1101/2025.11.06.687013v1
November 8, 2025 at 5:38 AM
Non-Enzymatic Structural Modifications Reshape Peptide Presentation and Antigen Recognition
https://www.biorxiv.org/content/10.1101/2025.11.06.687013v1
Immunopeptidomics can inform the design of mRNA vaccines for the delivery of Mycobacterium tuberculosis MHC class II antigens https://pubmed.ncbi.nlm.nih.gov/41191777/
November 6, 2025 at 5:39 AM
Immunopeptidomics can inform the design of mRNA vaccines for the delivery of Mycobacterium tuberculosis MHC class II antigens https://pubmed.ncbi.nlm.nih.gov/41191777/
Investigating the conformational landscape of human histidine-rich glycoprotein using amide HDX-MS https://pubmed.ncbi.nlm.nih.gov/41190777/
November 5, 2025 at 5:38 PM
Investigating the conformational landscape of human histidine-rich glycoprotein using amide HDX-MS https://pubmed.ncbi.nlm.nih.gov/41190777/
Epitope mapping of diagnostic antibodies targeting SARS-CoV-2 nucleocapsid protein using hydrogen-deuterium exchange mass spectrometry https://pubmed.ncbi.nlm.nih.gov/41126529/
November 5, 2025 at 5:40 AM
Epitope mapping of diagnostic antibodies targeting SARS-CoV-2 nucleocapsid protein using hydrogen-deuterium exchange mass spectrometry https://pubmed.ncbi.nlm.nih.gov/41126529/
In vitro Characterization of Peptidomimetic Proteolysis Targeting Chimera (PROTAC) as a Degrader of 3-Chymotrypsin-Like Protease (Mpro/3CLpro) against SARS-CoV-2
https://www.biorxiv.org/content/10.1101/2025.10.30.685646v1
November 3, 2025 at 5:37 PM
In vitro Characterization of Peptidomimetic Proteolysis Targeting Chimera (PROTAC) as a Degrader of 3-Chymotrypsin-Like Protease (Mpro/3CLpro) against SARS-CoV-2
https://www.biorxiv.org/content/10.1101/2025.10.30.685646v1