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pyustecheca.bsky.social
Patricia Yuste-Checa
@pyustecheca.bsky.social
88 followers 370 following 2 posts
Molecular biologist interested in proteostasis and neurodegeneration | Postdoc at Max Planck Institute Biochemistry
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Reposted by Patricia Yuste-Checa
mpibiochem.bsky.social
Max Planck Institute of Biochemistry @mpibiochem.bsky.social · Sep 5
Structural & functional analysis revealed that the extracellular #chaperone #clusterin functions through two tails in preventing protein aggregation.

❕Paper: www.nature.com/articles/s41...
❕Press Release: www.biochem.mpg.de/structure-of...

#Alzheimers @natsmb.nature.com @pyustecheca.bsky.social
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pyustecheca.bsky.social
Patricia Yuste-Checa @pyustecheca.bsky.social · Aug 14
Thank you @leokiss.bsky.social !!
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pyustecheca.bsky.social
Patricia Yuste-Checa @pyustecheca.bsky.social · Aug 8
Curious about the structure and functional analysis of one of the most abundant and enigmatic extracellular #chaperones and one of the highest genetic risk factor for developing late onset #Alzheimer’s disease? Check out our paper on Clusterin/ApoJ!
#proteostasis #apolipoprotein
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Structural analyses define the molecular basis of clusterin chaperone function
Nature Structural & Molecular Biology - The authors reveal a three-domain architecture of glycoprotein clusterin and show that the hydrophobic tails are crucial for clusterin’s functions...
rdcu.be
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Reposted by Patricia Yuste-Checa
natsmb.nature.com
Nature Structural & Molecular Biology @natsmb.nature.com · Aug 8
New online: Structural analyses define the molecular basis of clusterin chaperone function
Structural analyses define the molecular basis of clusterin chaperone function
Nature Structural & Molecular Biology, Published online: 08 August 2025; doi:10.1038/s41594-025-01631-4The authors reveal a three-domain architecture of glycoprotein clusterin and show that the hydrophobic tails are crucial for clusterin’s functions as an extracellular molecular chaperone and apolipoprotein, as well as for receptor binding and cellular uptake.
go.nature.com
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Reposted by Patricia Yuste-Checa
mamueller.bsky.social
Martin @mamueller.bsky.social · Feb 10
Exicted to share our latest review in @narjournal.bsky.social on how the ribosome coordinates mRNA decay with a focus on structural advances in the field.

#ribosome #mRNAdecay #translation
The ribosome as a platform to coordinate mRNA decay
Abstract. Messenger RNA (mRNA) homeostasis is a critical aspect of cellular function, involving the dynamic interplay between transcription and decay proce
academic.oup.com
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