Raimon Sunyer
@raimonsunyer.bsky.social
Associate professor at @unibarcelona.bsky.social • Previous RyC • NIH & @ibecbarcelona.bsky.social alumni • Interested in #CellMigration & #mechanobiology
Job Alert 📢
The group of Dr. Jordi Alcaraz (@ub.edu) offers a funded Postdoc (3y) or PhD (4y) to study immunosuppression in lung cancer.
In collaboration with @hospitalclinic.bsky.social's Immunology Unit.
📩 Apply: [email protected]
🕒 Start: 1st half of 2026
ℹ️ More info: Attached image
The group of Dr. Jordi Alcaraz (@ub.edu) offers a funded Postdoc (3y) or PhD (4y) to study immunosuppression in lung cancer.
In collaboration with @hospitalclinic.bsky.social's Immunology Unit.
📩 Apply: [email protected]
🕒 Start: 1st half of 2026
ℹ️ More info: Attached image
October 31, 2025 at 12:46 PM
Job Alert 📢
The group of Dr. Jordi Alcaraz (@ub.edu) offers a funded Postdoc (3y) or PhD (4y) to study immunosuppression in lung cancer.
In collaboration with @hospitalclinic.bsky.social's Immunology Unit.
📩 Apply: [email protected]
🕒 Start: 1st half of 2026
ℹ️ More info: Attached image
The group of Dr. Jordi Alcaraz (@ub.edu) offers a funded Postdoc (3y) or PhD (4y) to study immunosuppression in lung cancer.
In collaboration with @hospitalclinic.bsky.social's Immunology Unit.
📩 Apply: [email protected]
🕒 Start: 1st half of 2026
ℹ️ More info: Attached image
Today is Sant Jordi in Catalonia, a day we celebrate with 🌹 and 📖
Our fellow professor @rsalallonch.bsky.social has made beautiful handmade bookmarks 🔖 for everyone in the lab... each with a unique rose.
Bona diada!
Our fellow professor @rsalallonch.bsky.social has made beautiful handmade bookmarks 🔖 for everyone in the lab... each with a unique rose.
Bona diada!
April 23, 2025 at 1:28 PM
Today is Sant Jordi in Catalonia, a day we celebrate with 🌹 and 📖
Our fellow professor @rsalallonch.bsky.social has made beautiful handmade bookmarks 🔖 for everyone in the lab... each with a unique rose.
Bona diada!
Our fellow professor @rsalallonch.bsky.social has made beautiful handmade bookmarks 🔖 for everyone in the lab... each with a unique rose.
Bona diada!
… while for larger widths, cells lost the ability to migrate down the gradient due to smoother polarity re-orientation compared to the effective 1D dynamics observed at narrower widths
16/20
16/20
December 4, 2024 at 12:43 PM
… while for larger widths, cells lost the ability to migrate down the gradient due to smoother polarity re-orientation compared to the effective 1D dynamics observed at narrower widths
16/20
16/20
As predicted, we found that for intermediate widths, complex trajectories such as circles emerged…
15/20
15/20
December 4, 2024 at 12:42 PM
As predicted, we found that for intermediate widths, complex trajectories such as circles emerged…
15/20
15/20
The model also predicted that cell responses to ECM gradients depend on cell confinement.
With some widths displaying circular trajectories such as circles, and long trajectories down the gradient.
14/20
With some widths displaying circular trajectories such as circles, and long trajectories down the gradient.
14/20
December 4, 2024 at 12:40 PM
The model also predicted that cell responses to ECM gradients depend on cell confinement.
With some widths displaying circular trajectories such as circles, and long trajectories down the gradient.
14/20
With some widths displaying circular trajectories such as circles, and long trajectories down the gradient.
14/20
We captured the main features of this behavior with a coarse-grained molecular clutch model, which shows that both initial and long-term haptotactic dynamics can be explained by the interplay between friction differences at cell edges and cell persistence
13/20
13/20
December 4, 2024 at 12:39 PM
We captured the main features of this behavior with a coarse-grained molecular clutch model, which shows that both initial and long-term haptotactic dynamics can be explained by the interplay between friction differences at cell edges and cell persistence
13/20
13/20
However, they overcame this by increasing their actin polymerization velocity, partially compensating for these challenges
12/20
12/20
December 4, 2024 at 12:38 PM
However, they overcame this by increasing their actin polymerization velocity, partially compensating for these challenges
12/20
12/20
We found that cells migrating down the gradient experienced increased retrograde flow and more frequent lamellipodia collapses, making it challenging to move in that direction…
11/20
11/20
December 4, 2024 at 12:37 PM
We found that cells migrating down the gradient experienced increased retrograde flow and more frequent lamellipodia collapses, making it challenging to move in that direction…
11/20
11/20
How can cells migrate down the gradient 🤔?
To figure it out we measure actin retrograde flow, lamellipodia edge extension and polymerization velocity of cells migrating up and down the gradient
10/20
To figure it out we measure actin retrograde flow, lamellipodia edge extension and polymerization velocity of cells migrating up and down the gradient
10/20
December 4, 2024 at 12:37 PM
How can cells migrate down the gradient 🤔?
To figure it out we measure actin retrograde flow, lamellipodia edge extension and polymerization velocity of cells migrating up and down the gradient
10/20
To figure it out we measure actin retrograde flow, lamellipodia edge extension and polymerization velocity of cells migrating up and down the gradient
10/20
… in a sort of oscillatory pattern
December 4, 2024 at 12:37 PM
… in a sort of oscillatory pattern
Cells continued to migrate down the gradient!
8/20
8/20
December 4, 2024 at 12:37 PM
Cells continued to migrate down the gradient!
8/20
8/20
But what happened when cells reached the fibronectin peak?
7/20
7/20
December 4, 2024 at 12:37 PM
But what happened when cells reached the fibronectin peak?
7/20
7/20
This haptotaxis response was robust and independent of contractility
6/20
6/20
December 4, 2024 at 12:37 PM
This haptotaxis response was robust and independent of contractility
6/20
6/20
After adhering to narrow lanes of increasing fibronectin density, most cells polarized and migrated toward the highest protein density, demonstrating haptotaxis
5/20
5/20
December 4, 2024 at 12:37 PM
After adhering to narrow lanes of increasing fibronectin density, most cells polarized and migrated toward the highest protein density, demonstrating haptotaxis
5/20
5/20
To study haptotaxis, we used PRIMO photopatterning from Alveole on soft PDMS.
We designed the simplest experimental system we could think of: 1D exponential protein gradients.
We seeded cells on the same microscope to capture cell movement from the very beginning.
4/20
We designed the simplest experimental system we could think of: 1D exponential protein gradients.
We seeded cells on the same microscope to capture cell movement from the very beginning.
4/20
December 4, 2024 at 12:37 PM
To study haptotaxis, we used PRIMO photopatterning from Alveole on soft PDMS.
We designed the simplest experimental system we could think of: 1D exponential protein gradients.
We seeded cells on the same microscope to capture cell movement from the very beginning.
4/20
We designed the simplest experimental system we could think of: 1D exponential protein gradients.
We seeded cells on the same microscope to capture cell movement from the very beginning.
4/20
Haptotaxis is the directed cell migration along gradients of extracellular matrix (ECM) density.
2/20
2/20
December 4, 2024 at 12:37 PM
Haptotaxis is the directed cell migration along gradients of extracellular matrix (ECM) density.
2/20
2/20
Over her project, @icfortunato.bsky.social has become so skilled at micropatterning that her thesis cover is the image of a micropattern🎨👏
November 20, 2024 at 1:03 PM
Over her project, @icfortunato.bsky.social has become so skilled at micropatterning that her thesis cover is the image of a micropattern🎨👏
Thrilled to announce that @icfortunato.bsky.social successfully defended her thesis this week, co-supervised by @xaviertrepat.bsky.social and myself! 🎉
Isabela's outstanding work uncovered the unexpected complexity of haptotactic cell migration, challenging conventional views.
Isabela's outstanding work uncovered the unexpected complexity of haptotactic cell migration, challenging conventional views.
November 20, 2024 at 1:03 PM
Thrilled to announce that @icfortunato.bsky.social successfully defended her thesis this week, co-supervised by @xaviertrepat.bsky.social and myself! 🎉
Isabela's outstanding work uncovered the unexpected complexity of haptotactic cell migration, challenging conventional views.
Isabela's outstanding work uncovered the unexpected complexity of haptotactic cell migration, challenging conventional views.