Toman
redcabbage11.bsky.social
Toman
@redcabbage11.bsky.social
LC-MS and proteomics enthusiast
Reposted by Toman
Impact of Local Air Pressure on Ion Mobilities and Data Consistency in diaPASEF-Based High Throughput Proteomics pubs.acs.org/doi/10....

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#proteomics #prot-paper
January 24, 2025 at 5:20 PM
Reposted by Toman
I spend a bit of time talking to folk with plasma cohorts about MS vs affinity approaches for discovery. Thought it was worth a thread.

Most love the marketing. 5,000 proteins? 10,000 proteins? OLink was used in UK Biobank? Wow, mass spec is sooooo last year. Except life is not that simple.
Somalogic, Olink, and Alamar are casting doubt on each other’s data, proudly calling out lack of correlation.

I know why they do this but in the long run as it casts doubt on affinity approaches as a whole.

We will think lots of data is generated that is trash and won’t know which
November 21, 2024 at 9:30 AM