Rene Sugar
@renesugar.bsky.social
pmc.ncbi.nlm.nih.gov/articles/PMC...
"The findings of our study demonstrate that α-KG alleviates the pathogenesis of lupus and inhibits the activation and differentiation of B cells by increasing the expression of CD39."
"The findings of our study demonstrate that α-KG alleviates the pathogenesis of lupus and inhibits the activation and differentiation of B cells by increasing the expression of CD39."
α-Ketoglutarate alleviates the pathogenesis of lupus and inhibits the activation and differentiation of B cells by promoting the expression of CD39
The abnormal activation and differentiation of B cells play an important role in the pathogenesis of autoimmune diseases, including systemic lupus erythematosus (SLE). Alpha-ketoglutarate (α-KG), a key metabolite in the tricarboxylic acid cycle, has ...
pmc.ncbi.nlm.nih.gov
December 9, 2025 at 7:14 PM
pmc.ncbi.nlm.nih.gov/articles/PMC...
"The findings of our study demonstrate that α-KG alleviates the pathogenesis of lupus and inhibits the activation and differentiation of B cells by increasing the expression of CD39."
"The findings of our study demonstrate that α-KG alleviates the pathogenesis of lupus and inhibits the activation and differentiation of B cells by increasing the expression of CD39."
pmc.ncbi.nlm.nih.gov/articles/PMC...
The abnormal activation and differentiation of B cells play an important role in the pathogenesis of autoimmune diseases, including systemic lupus erythematosus (SLE)."
The abnormal activation and differentiation of B cells play an important role in the pathogenesis of autoimmune diseases, including systemic lupus erythematosus (SLE)."
α-Ketoglutarate alleviates the pathogenesis of lupus and inhibits the activation and differentiation of B cells by promoting the expression of CD39
The abnormal activation and differentiation of B cells play an important role in the pathogenesis of autoimmune diseases, including systemic lupus erythematosus (SLE). Alpha-ketoglutarate (α-KG), a key metabolite in the tricarboxylic acid cycle, has ...
pmc.ncbi.nlm.nih.gov
December 9, 2025 at 7:14 PM
pmc.ncbi.nlm.nih.gov/articles/PMC...
The abnormal activation and differentiation of B cells play an important role in the pathogenesis of autoimmune diseases, including systemic lupus erythematosus (SLE)."
The abnormal activation and differentiation of B cells play an important role in the pathogenesis of autoimmune diseases, including systemic lupus erythematosus (SLE)."
B1, B12, folic acid, copper deficiencies after #SARSCoV2 infection mimicking CIDP; also, new onset celiac #MECFS #LongCovid
bsky.app/profile/rene...
bsky.app/profile/rene...
B1, B12, folic acid, copper deficiencies after #SARSCoV2 infection mimicking CIDP; also, new onset celiac #MECFS #LongCovid
youtu.be/ycvOtNOSUsM?...
youtu.be/ycvOtNOSUsM?...
Mayo Clinic FINALLY Finds the cause and treatment plan for my Long-Covid!
YouTube video by TomithyTries
youtu.be
December 6, 2025 at 9:55 PM
B1, B12, folic acid, copper deficiencies after #SARSCoV2 infection mimicking CIDP; also, new onset celiac #MECFS #LongCovid
bsky.app/profile/rene...
bsky.app/profile/rene...
"The anticoagulant ticlopidine, which inhibits the purinergic receptor P2Y12, potentiated imipramine, elevating cAMP, a modulator of autophagy, reducing cell viability in culture, and increasing survival in glioma-bearing mice."
December 6, 2025 at 9:37 PM
"The anticoagulant ticlopidine, which inhibits the purinergic receptor P2Y12, potentiated imipramine, elevating cAMP, a modulator of autophagy, reducing cell viability in culture, and increasing survival in glioma-bearing mice."
"Once the presence of myeloneuropathy is established, all these patients should be subjected to a battery of tests."
"Blood levels of vitamin B12, folic acid, vitamins A, D, E, and K, along with levels of iron, methylmalonic acid, homocysteine, and calcium should be assessed."
"Blood levels of vitamin B12, folic acid, vitamins A, D, E, and K, along with levels of iron, methylmalonic acid, homocysteine, and calcium should be assessed."
December 6, 2025 at 6:22 PM
"Once the presence of myeloneuropathy is established, all these patients should be subjected to a battery of tests."
"Blood levels of vitamin B12, folic acid, vitamins A, D, E, and K, along with levels of iron, methylmalonic acid, homocysteine, and calcium should be assessed."
"Blood levels of vitamin B12, folic acid, vitamins A, D, E, and K, along with levels of iron, methylmalonic acid, homocysteine, and calcium should be assessed."
"Deficiencies of vitamin B12, folic acid, copper, and vitamin E may lead to myeloneuropathy with a clinical picture of subacute combined degeneration of the spinal cord."
December 6, 2025 at 6:22 PM
"Deficiencies of vitamin B12, folic acid, copper, and vitamin E may lead to myeloneuropathy with a clinical picture of subacute combined degeneration of the spinal cord."
Piezo2 Contributes to Traumatic Brain Injury by Activating the RhoA/ROCK1 Pathways
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
Piezo2 Contributes to Traumatic Brain Injury by Activating the RhoA/ROCK1 Pathways
Traumatic brain injury (TBI) can lead to short-term and long-term physical and cognitive impairments, which have significant impacts on patients, families, and society. Currently, treatment outcomes for this disease are often unsatisfactory, due at ...
pmc.ncbi.nlm.nih.gov
December 6, 2025 at 1:04 AM
Piezo2 Contributes to Traumatic Brain Injury by Activating the RhoA/ROCK1 Pathways
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
www.cell.com/cell/fulltex...
"- PIEZO2 regulates renin levels in mice
- Calcium oscillations in renin cells depend on PIEZO2
- PIEZO2 regulates induction of the RAAS during blood volume challenge
- PIEZO2 functions in parallel with other regulators of renin and the RAAS"
"- PIEZO2 regulates renin levels in mice
- Calcium oscillations in renin cells depend on PIEZO2
- PIEZO2 regulates induction of the RAAS during blood volume challenge
- PIEZO2 functions in parallel with other regulators of renin and the RAAS"
Renal PIEZO2 is an essential regulator of renin
The force-sensing ion channel PIEZO2 is an essential regulator of the renin-angiotensin-aldosterone
system (RAAS), a pathway that controls blood volume. Loss of PIEZO2 in the kidney
cells that produce...
www.cell.com
December 5, 2025 at 8:41 PM
www.cell.com/cell/fulltex...
"- PIEZO2 regulates renin levels in mice
- Calcium oscillations in renin cells depend on PIEZO2
- PIEZO2 regulates induction of the RAAS during blood volume challenge
- PIEZO2 functions in parallel with other regulators of renin and the RAAS"
"- PIEZO2 regulates renin levels in mice
- Calcium oscillations in renin cells depend on PIEZO2
- PIEZO2 regulates induction of the RAAS during blood volume challenge
- PIEZO2 functions in parallel with other regulators of renin and the RAAS"
PIEZO2 in somatosensory neurons controls gastrointestinal transit
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
PIEZO2 in somatosensory neurons controls gastrointestinal transit
The gastrointestinal tract is in a state of constant motion. These movements are tightly regulated by the presence of food and help digestion by mechanically breaking down and propelling gut content. Mechanical sensing in the gut is thought to be ...
pmc.ncbi.nlm.nih.gov
December 5, 2025 at 8:41 PM
PIEZO2 in somatosensory neurons controls gastrointestinal transit
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
"The current opinion piece aims to promote future angles of science and research in order to further elucidate the not entirely known initiating pathophysiology of #SARSCoV2 infection."
"The current opinion piece aims to promote future angles of science and research in order to further elucidate the not entirely known initiating pathophysiology of #SARSCoV2 infection."
Underlying Piezo2 Channelopathy-Induced Neural Switch of COVID-19 Infection
The focal “hot spot” neuropathologies in COVID-19 infection are revealing footprints of a hidden underlying collapse of a novel ultrafast ultradian Piezo2 signaling system within the nervous system. Paradoxically, the same initiating pathophysiology ...
pmc.ncbi.nlm.nih.gov
December 5, 2025 at 8:41 PM
pmc.ncbi.nlm.nih.gov/articles/PMC...
"The current opinion piece aims to promote future angles of science and research in order to further elucidate the not entirely known initiating pathophysiology of #SARSCoV2 infection."
"The current opinion piece aims to promote future angles of science and research in order to further elucidate the not entirely known initiating pathophysiology of #SARSCoV2 infection."
pmc.ncbi.nlm.nih.gov/articles/PMC...
"not to mention sleep disturbance with altered rapid eye movement sleep and cognitive deficit in the short term, and even as a consequence of #LongCovid."
"not to mention sleep disturbance with altered rapid eye movement sleep and cognitive deficit in the short term, and even as a consequence of #LongCovid."
Underlying Piezo2 Channelopathy-Induced Neural Switch of COVID-19 Infection
The focal “hot spot” neuropathologies in COVID-19 infection are revealing footprints of a hidden underlying collapse of a novel ultrafast ultradian Piezo2 signaling system within the nervous system. Paradoxically, the same initiating pathophysiology ...
pmc.ncbi.nlm.nih.gov
December 5, 2025 at 8:41 PM
pmc.ncbi.nlm.nih.gov/articles/PMC...
"not to mention sleep disturbance with altered rapid eye movement sleep and cognitive deficit in the short term, and even as a consequence of #LongCovid."
"not to mention sleep disturbance with altered rapid eye movement sleep and cognitive deficit in the short term, and even as a consequence of #LongCovid."
pmc.ncbi.nlm.nih.gov/articles/PMC...
"Moreover, this initiating Piezo2 channelopathy may also explain resultant autonomic dysregulation involving the medulla, hippocampus and heart rate regulation,"
"Moreover, this initiating Piezo2 channelopathy may also explain resultant autonomic dysregulation involving the medulla, hippocampus and heart rate regulation,"
Underlying Piezo2 Channelopathy-Induced Neural Switch of COVID-19 Infection
The focal “hot spot” neuropathologies in COVID-19 infection are revealing footprints of a hidden underlying collapse of a novel ultrafast ultradian Piezo2 signaling system within the nervous system. Paradoxically, the same initiating pathophysiology ...
pmc.ncbi.nlm.nih.gov
December 5, 2025 at 8:41 PM
pmc.ncbi.nlm.nih.gov/articles/PMC...
"Moreover, this initiating Piezo2 channelopathy may also explain resultant autonomic dysregulation involving the medulla, hippocampus and heart rate regulation,"
"Moreover, this initiating Piezo2 channelopathy may also explain resultant autonomic dysregulation involving the medulla, hippocampus and heart rate regulation,"
pmc.ncbi.nlm.nih.gov/articles/PMC...
"depending on the loci of #SARSCoV2 viral infection and intracellular entry."
"depending on the loci of #SARSCoV2 viral infection and intracellular entry."
Underlying Piezo2 Channelopathy-Induced Neural Switch of COVID-19 Infection
The focal “hot spot” neuropathologies in COVID-19 infection are revealing footprints of a hidden underlying collapse of a novel ultrafast ultradian Piezo2 signaling system within the nervous system. Paradoxically, the same initiating pathophysiology ...
pmc.ncbi.nlm.nih.gov
December 5, 2025 at 8:41 PM
pmc.ncbi.nlm.nih.gov/articles/PMC...
"depending on the loci of #SARSCoV2 viral infection and intracellular entry."
"depending on the loci of #SARSCoV2 viral infection and intracellular entry."
pmc.ncbi.nlm.nih.gov/articles/PMC...
"Therefore, the impairment of the proposed Piezo2-induced quantum mechanical free-energy-stimulated ultrafast proton-coupled tunneling seems to be the principal and critical underlying #COVID19 infection-induced primary damage along the brain axes,"
"Therefore, the impairment of the proposed Piezo2-induced quantum mechanical free-energy-stimulated ultrafast proton-coupled tunneling seems to be the principal and critical underlying #COVID19 infection-induced primary damage along the brain axes,"
Underlying Piezo2 Channelopathy-Induced Neural Switch of COVID-19 Infection
The focal “hot spot” neuropathologies in COVID-19 infection are revealing footprints of a hidden underlying collapse of a novel ultrafast ultradian Piezo2 signaling system within the nervous system. Paradoxically, the same initiating pathophysiology ...
pmc.ncbi.nlm.nih.gov
December 5, 2025 at 8:41 PM
pmc.ncbi.nlm.nih.gov/articles/PMC...
"Therefore, the impairment of the proposed Piezo2-induced quantum mechanical free-energy-stimulated ultrafast proton-coupled tunneling seems to be the principal and critical underlying #COVID19 infection-induced primary damage along the brain axes,"
"Therefore, the impairment of the proposed Piezo2-induced quantum mechanical free-energy-stimulated ultrafast proton-coupled tunneling seems to be the principal and critical underlying #COVID19 infection-induced primary damage along the brain axes,"
pmc.ncbi.nlm.nih.gov/articles/PMC...
"glutamatergic synapse loss, inflammation and neurological states with the central involvement of the hippocampus and the medulla, but also the initiating pathophysiology without #SARSCoV2 viral intracellular entry into neurons as well."
"glutamatergic synapse loss, inflammation and neurological states with the central involvement of the hippocampus and the medulla, but also the initiating pathophysiology without #SARSCoV2 viral intracellular entry into neurons as well."
Underlying Piezo2 Channelopathy-Induced Neural Switch of COVID-19 Infection
The focal “hot spot” neuropathologies in COVID-19 infection are revealing footprints of a hidden underlying collapse of a novel ultrafast ultradian Piezo2 signaling system within the nervous system. Paradoxically, the same initiating pathophysiology ...
pmc.ncbi.nlm.nih.gov
December 5, 2025 at 8:41 PM
pmc.ncbi.nlm.nih.gov/articles/PMC...
"glutamatergic synapse loss, inflammation and neurological states with the central involvement of the hippocampus and the medulla, but also the initiating pathophysiology without #SARSCoV2 viral intracellular entry into neurons as well."
"glutamatergic synapse loss, inflammation and neurological states with the central involvement of the hippocampus and the medulla, but also the initiating pathophysiology without #SARSCoV2 viral intracellular entry into neurons as well."
pmc.ncbi.nlm.nih.gov/articles/PMC...
"This Piezo2 channelopathy-induced neural switch could not only explain the initiation of disrupted cell-cell interactions, metabolic failure, microglial dysfunction, mitochondrial injury,"
"This Piezo2 channelopathy-induced neural switch could not only explain the initiation of disrupted cell-cell interactions, metabolic failure, microglial dysfunction, mitochondrial injury,"
Underlying Piezo2 Channelopathy-Induced Neural Switch of COVID-19 Infection
The focal “hot spot” neuropathologies in COVID-19 infection are revealing footprints of a hidden underlying collapse of a novel ultrafast ultradian Piezo2 signaling system within the nervous system. Paradoxically, the same initiating pathophysiology ...
pmc.ncbi.nlm.nih.gov
December 5, 2025 at 8:41 PM
pmc.ncbi.nlm.nih.gov/articles/PMC...
"This Piezo2 channelopathy-induced neural switch could not only explain the initiation of disrupted cell-cell interactions, metabolic failure, microglial dysfunction, mitochondrial injury,"
"This Piezo2 channelopathy-induced neural switch could not only explain the initiation of disrupted cell-cell interactions, metabolic failure, microglial dysfunction, mitochondrial injury,"
pmc.ncbi.nlm.nih.gov/articles/PMC...
"This common initiating microdamage is suggested to be the primary damage or the acquired channelopathy of the Piezo2 ion channel, leading to a principal gateway to pathophysiology."
"This common initiating microdamage is suggested to be the primary damage or the acquired channelopathy of the Piezo2 ion channel, leading to a principal gateway to pathophysiology."
Underlying Piezo2 Channelopathy-Induced Neural Switch of COVID-19 Infection
The focal “hot spot” neuropathologies in COVID-19 infection are revealing footprints of a hidden underlying collapse of a novel ultrafast ultradian Piezo2 signaling system within the nervous system. Paradoxically, the same initiating pathophysiology ...
pmc.ncbi.nlm.nih.gov
December 5, 2025 at 8:41 PM
pmc.ncbi.nlm.nih.gov/articles/PMC...
"This common initiating microdamage is suggested to be the primary damage or the acquired channelopathy of the Piezo2 ion channel, leading to a principal gateway to pathophysiology."
"This common initiating microdamage is suggested to be the primary damage or the acquired channelopathy of the Piezo2 ion channel, leading to a principal gateway to pathophysiology."
pmc.ncbi.nlm.nih.gov/articles/PMC...
"depending on the concentration and exposure to infecting #SARSCoV2 viruses."
"depending on the concentration and exposure to infecting #SARSCoV2 viruses."
Underlying Piezo2 Channelopathy-Induced Neural Switch of COVID-19 Infection
The focal “hot spot” neuropathologies in COVID-19 infection are revealing footprints of a hidden underlying collapse of a novel ultrafast ultradian Piezo2 signaling system within the nervous system. Paradoxically, the same initiating pathophysiology ...
pmc.ncbi.nlm.nih.gov
December 5, 2025 at 8:41 PM
pmc.ncbi.nlm.nih.gov/articles/PMC...
"depending on the concentration and exposure to infecting #SARSCoV2 viruses."
"depending on the concentration and exposure to infecting #SARSCoV2 viruses."
pmc.ncbi.nlm.nih.gov/articles/PMC...
"Paradoxically, the same initiating pathophysiology may underpin the systemic findings in #COVID19 infection, namely the multiorgan #SARSCoV2 infection-induced vascular pathologies and brain-body-wide systemic pro-inflammatory signaling,"
"Paradoxically, the same initiating pathophysiology may underpin the systemic findings in #COVID19 infection, namely the multiorgan #SARSCoV2 infection-induced vascular pathologies and brain-body-wide systemic pro-inflammatory signaling,"
Underlying Piezo2 Channelopathy-Induced Neural Switch of COVID-19 Infection
The focal “hot spot” neuropathologies in COVID-19 infection are revealing footprints of a hidden underlying collapse of a novel ultrafast ultradian Piezo2 signaling system within the nervous system. Paradoxically, the same initiating pathophysiology ...
pmc.ncbi.nlm.nih.gov
December 5, 2025 at 8:41 PM
pmc.ncbi.nlm.nih.gov/articles/PMC...
"Paradoxically, the same initiating pathophysiology may underpin the systemic findings in #COVID19 infection, namely the multiorgan #SARSCoV2 infection-induced vascular pathologies and brain-body-wide systemic pro-inflammatory signaling,"
"Paradoxically, the same initiating pathophysiology may underpin the systemic findings in #COVID19 infection, namely the multiorgan #SARSCoV2 infection-induced vascular pathologies and brain-body-wide systemic pro-inflammatory signaling,"
pmc.ncbi.nlm.nih.gov/articles/PMC...
"The focal "hot spot" neuropathologies in #COVID19 infection are revealing footprints of a hidden underlying collapse of a novel ultrafast ultradian Piezo2 signaling system within the nervous system."
"The focal "hot spot" neuropathologies in #COVID19 infection are revealing footprints of a hidden underlying collapse of a novel ultrafast ultradian Piezo2 signaling system within the nervous system."
Underlying Piezo2 Channelopathy-Induced Neural Switch of COVID-19 Infection
The focal “hot spot” neuropathologies in COVID-19 infection are revealing footprints of a hidden underlying collapse of a novel ultrafast ultradian Piezo2 signaling system within the nervous system. Paradoxically, the same initiating pathophysiology ...
pmc.ncbi.nlm.nih.gov
December 5, 2025 at 8:41 PM
pmc.ncbi.nlm.nih.gov/articles/PMC...
"The focal "hot spot" neuropathologies in #COVID19 infection are revealing footprints of a hidden underlying collapse of a novel ultrafast ultradian Piezo2 signaling system within the nervous system."
"The focal "hot spot" neuropathologies in #COVID19 infection are revealing footprints of a hidden underlying collapse of a novel ultrafast ultradian Piezo2 signaling system within the nervous system."