Rob Clarke
@robclarkelab.bsky.social
320 followers
260 following
8 posts
Breast Biology Lab, UniManchester; researching stem cell signalling in development and cancer. Models inc. patient-derived organoids and xenografts.
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Reposted by Rob Clarke
Reposted by Rob Clarke
Rob Clarke
@robclarkelab.bsky.social
· Aug 6
Proteomics Identifies Osteomodulin as a Promoter of Breast Cancer Bone Metastasis via CDK1 Activation
Metastasis to different organs remains the main cause of mortality in breast cancer. Molecular predictors of metastasis are limited as well as therapeutic options. Here, we conducted quantitative prot...
doi.org
Rob Clarke
@robclarkelab.bsky.social
· Aug 6
HES1 oscillations are required for cell cycle progression and re-entry in oestrogen receptor positive breast cancer cells
Long-term recurrence in breast cancer is driven by reactivation of dormant disseminated tumour cells (DTCs) and remains a major clinical challenge, particularly in oestrogen receptor positive (ER⁺) tu...
doi.org
Reposted by Rob Clarke
Reposted by Rob Clarke
Reposted by Rob Clarke
Reposted by Rob Clarke
Reposted by Rob Clarke
Paloma Garcia
@pggarcialab.bsky.social
· Apr 19
MYBL2 maintains stemness and promotes theta-mediated end joining in triple negative breast cancer
Triple negative breast cancer (TNBC) has a poor prognosis due to limited treatment options and high metastasis risk. Breast cancer (BC) stem/progenitor cells, also known as tumour initiating cells, ar...
www.biorxiv.org
Reposted by Rob Clarke
Rob Clarke
@robclarkelab.bsky.social
· Dec 16
(BBSRC NWD) Uncovering the roles of collagen VI in normal breast tissue stiffness, signalling and proliferation at The University of Manchester on FindAPhD.com
PhD Project - (BBSRC NWD) Uncovering the roles of collagen VI in normal breast tissue stiffness, signalling and proliferation at The University of Manchester, listed on FindAPhD.com
www.findaphd.com