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Roslyn Bill @roslynbill.bsky.social · May 28

This is a great opportunity to do some cool science with @grantpellowe.bsky.social at @astonaime.bsky.social!

Grant Pellowe @grantpellowe.bsky.social · May 28

Re-advertising! Closes September 1st.

💧 Interested in understanding how Aquaporins fold into membranes as they're being synthesised? 💧

If so, come and do your PhD with me, @kitchenphil.bsky.social and @roslynbill.bsky.social at @astonaime.bsky.social

tinyurl.com/5dc23mu3

Reach out for details!

Delineating stages of Aquaporin biogenesis at Aston University on FindAPhD.com

PhD Project - Delineating stages of Aquaporin biogenesis at Aston University, listed on FindAPhD.com

tinyurl.com

Roslyn Bill @roslynbill.bsky.social · Feb 26

This is a great opportunity to do your PhD in a supportive team working on cool science! Apply today!

Grant Pellowe @grantpellowe.bsky.social · Feb 24

💧 Are you interested in understanding how Aquaporins fold into membranes as they're being synthesised? 💧

If so, come and do your PhD with me, @kitchenphil.bsky.social and @roslynbill.bsky.social at @astonaime.bsky.social!

www.findaphd.com/phds/project...

Reach out for further details!

Delineating stages of Aquaporin biogenesis at Aston University on FindAPhD.com

PhD Project - Delineating stages of Aquaporin biogenesis at Aston University, listed on FindAPhD.com

www.findaphd.com

Roslyn Bill @roslynbill.bsky.social · Dec 6

It is important that we discuss how these molecules work as they are routinely used to define whether a process is dependent upon AQP4 or not. This has fundamental implications for understanding glymphatics.

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Roslyn Bill @roslynbill.bsky.social · Dec 6

Yes, that is right. We were really surprised by that, too, as we chose them as positive controls.
These compounds should be used with care!

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Roslyn Bill @roslynbill.bsky.social · Dec 6

Our study suggests that two commercially available molecules should be used with care when investigating the AQP4 dependence of biological mechanisms.

@ungerlucas.bsky.social @kitchenphil.bsky.social

bioRxivpreprint @biorxivpreprint.bsky.social · Dec 5

AER-270 and TGN-020 are not aquaporin-4 water channel blockers https://www.biorxiv.org/content/10.1101/2024.12.04.625365v1

Aquaporin-4 (AQP4) is the most abundant water channel protein in the brain. It controls water homeos

www.biorxiv.org

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Reposted by Roslyn Bill

Phil Kitchen @kitchenphil.bsky.social · Dec 5

Our lab's first Biorxiv deposition is live!

We show that two commercially-available "aquaporin-4 inhibitors" do not inhibit aquaporin-4 as previously described.

www.biorxiv.org/content/10.1...

AER-270 and TGN-020 are not aquaporin-4 water channel blockers

Aquaporin-4 (AQP4) is the most abundant water channel protein in the brain. It controls water homeostasis, facilitates glymphatic function and is a drug target for brain edema following injury or stro...

www.biorxiv.org

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Reposted by Roslyn Bill

Phil Kitchen @kitchenphil.bsky.social · Dec 5

Lucas is now on bluesky at @ungerlucas.bsky.social

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Reposted by Roslyn Bill

Phil Kitchen @kitchenphil.bsky.social · Dec 5

This is (bluesky-less) Lucas Unger's first manuscript from his PhD work, and a big team effort involving members of #TeamAQP across the world. We are keen to get feedback on our study, and urge caution to researchers using AER-270 or TGN-020 in their work!

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Roslyn Bill @roslynbill.bsky.social · Dec 5

It is great to see this work out and we look forward to discussions on how the field should scrutinise historical data on AQP4 in brain fluid homeostasis and glymphatic flow. The take-home message is to please use these molecules with care!

@astonaime.bsky.social

Phil Kitchen @kitchenphil.bsky.social · Dec 5

Our lab's first Biorxiv deposition is live!

We show that two commercially-available "aquaporin-4 inhibitors" do not inhibit aquaporin-4 as previously described.

www.biorxiv.org/content/10.1...

AER-270 and TGN-020 are not aquaporin-4 water channel blockers

Aquaporin-4 (AQP4) is the most abundant water channel protein in the brain. It controls water homeostasis, facilitates glymphatic function and is a drug target for brain edema following injury or stro...

www.biorxiv.org

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Roslyn Bill @roslynbill.bsky.social · Dec 4

Just back from my last gig as Chair of @ukri.org BBSRC Research Committee E.

It has been a privilege to spend the last 6 years supporting the UK's best and brightest bioscientists and biotechnologists in their transition to independence!

@astonpress.bsky.social @astonpress.bsky.social

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Reposted by Roslyn Bill

Ute Hellmich @hellmichgroup.bsky.social · Dec 1

Wow! 🥳 Starter Pack 1 on membrane proteins, lipids and transport processes has maxed out, so I made a 2nd one to reunite our community!

Please share widely and reach out if you love lipids and the proteins that frolick at and in the membrane! 🧪

go.bsky.app/PnXecJZ

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Roslyn Bill @roslynbill.bsky.social · Dec 1

Done!

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Roslyn Bill @roslynbill.bsky.social · Dec 1

Great idea. Count me in. I like calcium channels! Would you like to join the AQP party?

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Reposted by Roslyn Bill

Alan Goddard @alangoddard.bsky.social · Nov 15

Delighted that our MIBTP Landscape Award has been funded. I'd be very grateful for any sharing of this, it's a great programme and I'm not just saying that as I'm one of the directors 🤣.

warwick.ac.uk/fac/cross_fa...

Midlands Integrative Biosciences Training Partnership (MIBTP)

warwick.ac.uk

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Reposted by Roslyn Bill

Alan Goddard @alangoddard.bsky.social · Nov 19

Our new research institute Aston Institute for Membrane Excellence @astonaime.bsky.social is now here. Give us a follow for all things membranes! www.aston.ac.uk/research/aime

AIME - Aston Institute for Membrane Excellence

www.aston.ac.uk

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Roslyn Bill @roslynbill.bsky.social · Nov 27

Welcome to the AQP party!

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Roslyn Bill @roslynbill.bsky.social · Nov 22

Great idea. I just did this, too!

Yamuna Krishnan @krishnanyamuna.bsky.social · Nov 22

Alright! 👍 I’m loving this!

Andy Aydın-Aitchison @andy8chi.bsky.social · Nov 21

Academics wanting to 'verify' their Bluesky profile as genuine might give an ORCID identifier in their profile and link back to their Bluesky profile from ORCID.

#AcademicSky

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Reposted by Roslyn Bill

Ian Harrison @ianharrisonneuro.bsky.social · Nov 20

Ain't no party like an AQP party! 🥳

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Roslyn Bill @roslynbill.bsky.social · Nov 20

This is the beginnings of a Starter Pack for aquaporin channel fans. Join the Aquaporin Party!

go.bsky.app/Hdhw78e

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Roslyn Bill @roslynbill.bsky.social · Nov 18

Join me to do your PhD on aquaporins as part of the Midlands Integrative Biosciences Training Partnership funded by BBSRC. Please get in touch if you are interested! The project is co-supervised by @kitchenphil.bsky.social

The deadline is 16th January 2025!

warwick.ac.uk/fac/cross_fa...

Professor Roslyn Bill

warwick.ac.uk

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Roslyn Bill @roslynbill.bsky.social · Nov 16

Great work, Ute!

Ute Hellmich @hellmichgroup.bsky.social · Nov 16

Ok, trying to bring my community back together... I created a starter pack for lipids and membrane protein aficionados!

Feel free to share, add and distribute, so we can come together again! 😍

go.bsky.app/AEeXh86

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Reposted by Roslyn Bill

Alan Goddard @alangoddard.bsky.social · Aug 7

Decided to try and be more active here. Check out our new institute, Aston Institute for Membrane Excellence. If you like membranes (of any kind) please get in touch! www.aston.ac.uk/research/aime

AIME - Aston Institute for Membrane Excellence

www.aston.ac.uk

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Roslyn Bill @roslynbill.bsky.social · Nov 13

Alan is an excellent supervisor and this is a great opportunity!

Alan Goddard @alangoddard.bsky.social · Nov 13

🚨🚨 Fully funded PhD available in my lab on an exciting (I would say that!) interdisciplinary intersectoral project. Contact me for a chat!

www.findaphd.com/phds/project...

Bioinspired membranes for lithium recovery at Aston University on FindAPhD.com

PhD Project - Bioinspired membranes for lithium recovery at Aston University, listed on FindAPhD.com

www.findaphd.com