Raju Tomer
@rtomer.bsky.social
Associate Prof. @ Columbia University
Are we born as a blank slate, or with a neural “operating system”?
We show hippocampal neurons self-organize into memory-like networks in a dish.
We also introduce IncStim, a compact, all-optical sys. for closed-loop act. imaging/manipulation inside an incubator.
www.biorxiv.org/content/10.6...
We show hippocampal neurons self-organize into memory-like networks in a dish.
We also introduce IncStim, a compact, all-optical sys. for closed-loop act. imaging/manipulation inside an incubator.
www.biorxiv.org/content/10.6...
In vitro reconstitution of hippocampal cell assemblies
Three-dimensional neuronal cultures, such as brain organoids, have proven effective for in vitro modeling of brain development and disease. However, it remains unclear whether these systems can intrin...
www.biorxiv.org
December 20, 2025 at 10:19 AM
Are we born as a blank slate, or with a neural “operating system”?
We show hippocampal neurons self-organize into memory-like networks in a dish.
We also introduce IncStim, a compact, all-optical sys. for closed-loop act. imaging/manipulation inside an incubator.
www.biorxiv.org/content/10.6...
We show hippocampal neurons self-organize into memory-like networks in a dish.
We also introduce IncStim, a compact, all-optical sys. for closed-loop act. imaging/manipulation inside an incubator.
www.biorxiv.org/content/10.6...
Sharing new work from us+collaborators. We take a step toward making organ-scale, subcellular 3D imaging as scalable & affordable as next-gen sequencing, to eventually fuel next-gen of AI-foundational models of tissues, organs. www.biorxiv.org/content/10.1...
Videos: www.youtube.com/playlist?lis...
Videos: www.youtube.com/playlist?lis...
Scalable, affordable, submicron 3D imaging of multi-centimeter scale samples. - YouTube
Hybrid Solid-Liquid Optics Enable Scalable, High-Resolution, Multi-Immersion Light-Sheet Microscopy. Authors: Cheng Gong, Pauline Affatato, Matt Fay, Sudha R...
www.youtube.com
November 4, 2025 at 6:05 PM
Sharing new work from us+collaborators. We take a step toward making organ-scale, subcellular 3D imaging as scalable & affordable as next-gen sequencing, to eventually fuel next-gen of AI-foundational models of tissues, organs. www.biorxiv.org/content/10.1...
Videos: www.youtube.com/playlist?lis...
Videos: www.youtube.com/playlist?lis...
A milestone worth reflecting on - 1000 citations for our cleared tissue light sheet paper - the COLM.
Gratifying that core ideas have stood the test of time and are broadly adopted:
Cuvette-based sample mounting;
Virtual slit effect with rolling shutter CMOS;
and Linear adaptive offset correction!
Gratifying that core ideas have stood the test of time and are broadly adopted:
Cuvette-based sample mounting;
Virtual slit effect with rolling shutter CMOS;
and Linear adaptive offset correction!
October 3, 2025 at 9:02 PM
A milestone worth reflecting on - 1000 citations for our cleared tissue light sheet paper - the COLM.
Gratifying that core ideas have stood the test of time and are broadly adopted:
Cuvette-based sample mounting;
Virtual slit effect with rolling shutter CMOS;
and Linear adaptive offset correction!
Gratifying that core ideas have stood the test of time and are broadly adopted:
Cuvette-based sample mounting;
Virtual slit effect with rolling shutter CMOS;
and Linear adaptive offset correction!
Love this!! I don’t think I’ve ever seen anything like this before -- high-res light sheet microscopes designated for use by individual researchers in one lab!! Fantastic to see real-world impact emerging, starting with Bianca’s lab at JLG, Columbia!
✨ Exciting news!
SLICE™, our award-winning light sheet microscope, is now up and running at the Marlin Lab at Columbia University @columbiauniversity.bsky.social, ready to power advanced 3D imaging and accelerate discovery.
Here’s to more breakthroughs ahead! 🚀🔬
#3DImaging #ResearchInnovation
SLICE™, our award-winning light sheet microscope, is now up and running at the Marlin Lab at Columbia University @columbiauniversity.bsky.social, ready to power advanced 3D imaging and accelerate discovery.
Here’s to more breakthroughs ahead! 🚀🔬
#3DImaging #ResearchInnovation
August 28, 2025 at 12:37 AM
Love this!! I don’t think I’ve ever seen anything like this before -- high-res light sheet microscopes designated for use by individual researchers in one lab!! Fantastic to see real-world impact emerging, starting with Bianca’s lab at JLG, Columbia!
Reposted by Raju Tomer
We’re proud to work with Dr. Tomer & his team at Columbia University to bring SLICE to life, a compact, affordable light-sheet microscope making 3D imaging more accessible worldwide.
📖 magazine.columbia.edu/article/3d-i...
@rtomer.bsky.social @columbiauniversity.bsky.social
#SLICE #lightsheet
📖 magazine.columbia.edu/article/3d-i...
@rtomer.bsky.social @columbiauniversity.bsky.social
#SLICE #lightsheet
3D Imaging Just Got Easier
Columbia researchers have developed a powerful new microscope that could enable more scientists around the world to conduct cutting-edge biomedical research.
magazine.columbia.edu
May 5, 2025 at 3:30 PM
We’re proud to work with Dr. Tomer & his team at Columbia University to bring SLICE to life, a compact, affordable light-sheet microscope making 3D imaging more accessible worldwide.
📖 magazine.columbia.edu/article/3d-i...
@rtomer.bsky.social @columbiauniversity.bsky.social
#SLICE #lightsheet
📖 magazine.columbia.edu/article/3d-i...
@rtomer.bsky.social @columbiauniversity.bsky.social
#SLICE #lightsheet
Reposted by Raju Tomer
We had to join the trend.
Introducing: Jack Glaser, Founder and President of MBF Bioscience —now an action figure. Complete with microscope, field journal, and trusty lab dog. 🧠🐕
In science, there are no small people—just big ideas.
#ScienceMatters #STEM #Microscopy
Introducing: Jack Glaser, Founder and President of MBF Bioscience —now an action figure. Complete with microscope, field journal, and trusty lab dog. 🧠🐕
In science, there are no small people—just big ideas.
#ScienceMatters #STEM #Microscopy
April 16, 2025 at 6:34 PM
We had to join the trend.
Introducing: Jack Glaser, Founder and President of MBF Bioscience —now an action figure. Complete with microscope, field journal, and trusty lab dog. 🧠🐕
In science, there are no small people—just big ideas.
#ScienceMatters #STEM #Microscopy
Introducing: Jack Glaser, Founder and President of MBF Bioscience —now an action figure. Complete with microscope, field journal, and trusty lab dog. 🧠🐕
In science, there are no small people—just big ideas.
#ScienceMatters #STEM #Microscopy
Reposted by Raju Tomer
Our digital times :-)
March 20, 2025 at 1:33 PM
Our digital times :-)
Reposted by Raju Tomer
Quite an essay on the basis of cancer entitled "The End of the Genetic Paradigm of Cancer" @plosbiology.org arguing against the primacy of somatic mutations (traditional model) and cells, invoking gene regulatory networks and tissue
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
March 18, 2025 at 6:25 PM
Quite an essay on the basis of cancer entitled "The End of the Genetic Paradigm of Cancer" @plosbiology.org arguing against the primacy of somatic mutations (traditional model) and cells, invoking gene regulatory networks and tissue
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Reposted by Raju Tomer
have ppl found any funders that support toolmaking? I want to keep making tools for people, but there is a seemingly irresistible force pushing us towards hypothesis-driven research. In my experience, funders don't want to hear about tech dev. Any insights? for both neuro & climate would be great tx
December 19, 2024 at 11:32 PM
have ppl found any funders that support toolmaking? I want to keep making tools for people, but there is a seemingly irresistible force pushing us towards hypothesis-driven research. In my experience, funders don't want to hear about tech dev. Any insights? for both neuro & climate would be great tx
Reposted by Raju Tomer
Delighted to highlight our new paper in
@natureportfolio.bsky.social entitled 'Synaptic basis of feature selectivity in hippocampal neurons' (thread below 👇): www.nature.com/articles/s41...
@natureportfolio.bsky.social entitled 'Synaptic basis of feature selectivity in hippocampal neurons' (thread below 👇): www.nature.com/articles/s41...
Synaptic basis of feature selectivity in hippocampal neurons - Nature
A temporally asymmetric synaptic plasticity kernel results from bidirectional modifications of synaptic weights around the induction of a place field.
www.nature.com
December 18, 2024 at 10:00 PM
Delighted to highlight our new paper in
@natureportfolio.bsky.social entitled 'Synaptic basis of feature selectivity in hippocampal neurons' (thread below 👇): www.nature.com/articles/s41...
@natureportfolio.bsky.social entitled 'Synaptic basis of feature selectivity in hippocampal neurons' (thread below 👇): www.nature.com/articles/s41...