Lightnews — Scholar-powered news

Ryszard Wimmer @ryszardwimmer.bsky.social · Aug 9

✨ #FluorescentFriday ✨
SOX2-positive cells forming the heart of the developing human cerebellum 🧡, framed by a glowing outline of PAX6-positive neighbors 💙. A tiny but breathtaking glimpse into brain development under the microscope. 🧠💡

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Ryszard Wimmer @ryszardwimmer.bsky.social · Aug 9

2D, but never flat — neural progenitors glowing blue & yellow, and me falling for biology all over again 😍

Ryszard Wimmer @ryszardwimmer.bsky.social · May 26

There is no better place to talk about Radial Glia Cells than on the beaches right under the Etna in Gardini Naxos @corticodevelopment.bsky.social !

Ryszard Wimmer @ryszardwimmer.bsky.social · May 16

Excellent work from @silvianeuro.bsky.social lab on DCHS1 ! @mveronicapravata.bsky.social congratulations!
www.biorxiv.org/content/10.1...

DCHS1 Modulates Forebrain Proportions in Modern Humans via a Glycosylation Change

Comparative anatomical studies of primates and extinct hominins, including Neanderthals, show that the modern human brain is characterised by a disproportionately enlarged neocortex relative to the st...

www.biorxiv.org

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Reposted by Ryszard Wimmer

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · May 15

DCHS1 Modulates Forebrain Proportions in Modern Humans via a Glycosylation Change https://www.biorxiv.org/content/10.1101/2025.05.14.654031v1

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Ryszard Wimmer @ryszardwimmer.bsky.social · Apr 11

sciencebank.com/development-... A cool and smooth blog post on stem cell use, validation, quality control and on how to share Your precious stem cells with others! #stemcells I hope You enjoy!

Our community is thrilled to have Dr. Ekin Ucuncu join the ReplicApril conversation with a guest post on how shared standards in stem cell research can help drive reproducibility forward.

sciencebank.com

Ryszard Wimmer @ryszardwimmer.bsky.social · Feb 28

In the neon glow of the cortex, a Radial Glia stretched its long, guiding arm. Suddenly, a rogue cell snatched a piece of its scaffold, disrupting the neural highway. "Hey!" it pulsed, but the thief vanished into the synaptic shadows. The network flickered—order shaken. #fluorescentfriday

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Reposted by Ryszard Wimmer

Awais Javed @itsmeawais.bsky.social · Feb 20

Delighted to have this out as a preprint! Thanks to all authors, especially @estherkli.bsky.social and @djabaudon.bsky.social for leading the work. If you are interested in how conserved genes played a part in evolving human brains, give it a read!

Esther Klingler @estherkli.bsky.social · Feb 20

✨ We tend to think of species-specific differences as resulting from the presence of species-specific genes. In our latest work with @djabaudon.bsky.social, we show that building brains is not only about which genes you use, but also about when and where you do.
www.biorxiv.org/content/10.1...

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Reposted by Ryszard Wimmer

Denis Jabaudon @djabaudon.bsky.social · Feb 20

New preprint out from the lab, check out thread below!

Esther Klingler @estherkli.bsky.social · Feb 20

✨ We tend to think of species-specific differences as resulting from the presence of species-specific genes. In our latest work with @djabaudon.bsky.social, we show that building brains is not only about which genes you use, but also about when and where you do.
www.biorxiv.org/content/10.1...

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Ryszard Wimmer @ryszardwimmer.bsky.social · Jan 30

While waiting on my paper to get rejected or accepted 🤗 I discovered that playing with clay is just a beautiful disconnection from everyday problems. Here is my first take at a flower-shaped candle ! #pottery #nature #flowers #qualitytime #science

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Ryszard Wimmer @ryszardwimmer.bsky.social · Jan 28

I’m not even from the Crick, nor from England but I completely agree with the contents of the abstract !

Ryszard Wimmer @ryszardwimmer.bsky.social · Jan 23

I still remember try to make some of these tricks on Tony hawk when it came out on PC 🫠

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Ryszard Wimmer @ryszardwimmer.bsky.social · Jan 17

Images and all scientific data needs a voice. @clarissebrunet.bsky.social is running a beautiful podcast in spannish called Ciencia en Voz Alta „Science Out Loud”. It’s a beautiful series of podcasts with scientists on spotify talking about their research! cienciaenvozalta.com
Enjoy! 🎧

Ciencia en Voz Alta (Website)

cienciaenvozalta.com

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Ryszard Wimmer @ryszardwimmer.bsky.social · Jan 10

🌟 Absolutely mesmerizing! The vibrant interplay of Sox2 in sky blue with proliferating neural stem cells creates a brilliant window into brain development. A perfect showcase of science meeting art—thanks for sharing this beauty! 🧠💡

Ryszard Wimmer @ryszardwimmer.bsky.social · Jan 10

www.biorxiv.org/content/10.1...

Two independent translocation modes drive neural stem cell dissemination into the human fetal cortex

The strong size increase of the human neocortex is supported by the amplification and the basal translocation of a neural stem cell population, the basal radial glial cells (or bRG cells). Here, using...

www.biorxiv.org

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Ryszard Wimmer @ryszardwimmer.bsky.social · Jan 9

Thank You! 🤗

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Ryszard Wimmer @ryszardwimmer.bsky.social · Jan 9

Thank You! 😍

Ryszard Wimmer @ryszardwimmer.bsky.social · Jan 9

Hello! My PhD pre-print is out on biorxiv, where in the Lab of @alexbaffet.bsky.social we managed to unravel how bRG (oRG) cells translocate and colonise the developing human brain. Interestingly features of these translocations are conserved in glioblastoma! Link : www.biorxiv.org/content/10.1...

Two independent translocation modes drive neural stem cell dissemination into the human fetal cortex

The strong size increase of the human neocortex is supported by the amplification and the basal translocation of a neural stem cell population, the basal radial glial cells (or bRG cells). Here, using...

www.biorxiv.org

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Reposted by Ryszard Wimmer

Alexandre Baffet @alexbaffet.bsky.social · Jan 9

I want to thank everyone involved in this work on top of Ryszard who did an amazing job. Laure Coquand, Amandine Di Cicco, Christophe Chehade, @clarissebrunet.bsky.social @pauline-lestienne.bsky.social, Julia Ladewig, Karin Forsberg-Nilsson, Fabien Guimiot and our fantastic imaging facility!

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Reposted by Ryszard Wimmer

Alexandre Baffet @alexbaffet.bsky.social · Jan 9

Using 9 different glioblastoma lines we show that IST and MST both occur, although not in all cells, reflecting the heterogeneity of these tumors. Strikingly, glioblastoma undergoing IST and MST did so using the same molecular mechanism as the ones identified here in bRG cells.

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Reposted by Ryszard Wimmer

Alexandre Baffet @alexbaffet.bsky.social · Jan 9

Finally, because past work form @bhadurilab.bsky.social and others had shown a facilitating similarity between bRG cells and glioblastoma cells (including the presence of MST), we tested the conservation of our mechanisms in these cells.

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Reposted by Ryszard Wimmer

Alexandre Baffet @alexbaffet.bsky.social · Jan 9

Therefore, microtubule related genes are more likely to affect human oSVZ expansion than actin-related ones.

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Reposted by Ryszard Wimmer

Alexandre Baffet @alexbaffet.bsky.social · Jan 9

So MST and IST are totally different mechanisms, but what is their relative contribution to bRG dissemination in the human fetal cortex? After extensive recording in fetal explants, Ryszard could show that IST contributes to 85% of the total basal movement, while MST contributes to 15%.

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Reposted by Ryszard Wimmer

Alexandre Baffet @alexbaffet.bsky.social · Jan 9

Mechanistically, we demonstrate that MST is dependent on the mitotic cell rounding pathway, that enables most adherent cells to round up for proper chromosome segregation through an increase of the cell cortex stiffness. Knocking down ERM proteins (Ezrin-Radixin-Moesin) or Vimentin all alter MST.

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Reposted by Ryszard Wimmer

Alexandre Baffet @alexbaffet.bsky.social · Jan 9

We next focused our attention on MST and, using Sir-tubulin dyes, first showed that it occurred after nuclear envelope breakdown, and is therefore a mitotic spindle translocation event!!! I find this crazy, and to our knowledge quite unique in biology (so far...).

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