Sachin Sejuwal
sachinsejuwal.bsky.social
Sachin Sejuwal
@sachinsejuwal.bsky.social
# B. Tech; M.Sc. in Biotechnology

# Seeking a PhD in fungal natural products.

# Reach me: [email protected]

Kathmandu, Nepal
Reposted by Sachin Sejuwal
Rapid appearance of caffeine in plasma of rats exposed to e-cigarette smoke, analyzed using a validated LC-MS/MS method #JPBA www.sciencedirect.com/science/arti...
Rapid appearance of caffeine in plasma of rats exposed to e-cigarette smoke, analyzed using a validated LC-MS/MS method
Although electronic cigarettes (e-cigarettes) that enable inhalation of caffeine (Caf) are commercially available, the pharmacokinetic (PK) properties…
www.sciencedirect.com
December 13, 2025 at 8:04 PM
Reposted by Sachin Sejuwal
Recommended reading for those of us who study actinomycetes using untargeted metabolomics. Incredible work by @amcaraballor.bsky.social, @pieterdorrestein.bsky.social, and collaborators. rdcu.be/eSRxT
The undiscovered natural product potential of Actinomycetes
The Journal of Antibiotics - The undiscovered natural product potential of Actinomycetes
rdcu.be
December 3, 2025 at 10:40 PM
Reposted by Sachin Sejuwal
Mycologists estimate that just 3 to 5 percent of global fungal biodiversity has been described, with millions of fungal species still waiting to be identified.

My latest for Substack exploring Mycology and learning from a PhD Mycologist around the world of fungi.

#mycology #fungi
Mycology: The Secret Life Of Fungi
Mycologists estimate that just 3 to 5 percent of global fungal biodiversity has been described, with millions of fungal species still waiting to be identified.
open.substack.com
December 12, 2025 at 4:10 PM
Reposted by Sachin Sejuwal
“… These compounds, part of a rare group known as fungal RiPPs, were bioengineered for potency and appear to disrupt cancer cell division with high specificity.”

#ddrm
www.sciencedaily.com/releases/202...
From cursed tomb fungus to cancer cure: Aspergillus flavus yields potent new drug
In a remarkable twist of science, researchers have transformed a fungus long associated with death into a potential weapon against cancer. Found in tombs like that of King Tut, Aspergillus flavus was ...
www.sciencedaily.com
August 1, 2025 at 3:44 AM
Reposted by Sachin Sejuwal
Researchers demonstrated that the antibiotic hygromycin B is both an effective and general inducer of fungal metabolites. The antibiotic stimulated compound production in 71% of fungal strains tested and generated three completely novel compounds. cen.acs.org/biological-c... #chemsky 🧪
Antibiotic unlocks fungi’s ability to make new molecules
Hygromycin B stimulates metabolite production in 20 fungal strains
cen.acs.org
October 16, 2025 at 1:44 PM
Reposted by Sachin Sejuwal
Complementarity assessment of NMR and LC-HRMS profiling in natural products: an application on mastic leaves #Metabolomics link.springer.com/article/10.1...
Complementarity assessment of NMR and LC-HRMS profiling in natural products: an application on mastic leaves - Metabolomics
Introduction Metabolomics has proven to be a powerful tool in the natural products’ field for the investigation of plant extracts and the exploration of compounds with eminent biological and pharmacol...
link.springer.com
December 1, 2025 at 7:09 PM
What an impressive study !

They developed a high-throughput metabolomics workflow linking luminescent bioreporters with LC–MS/MS data, enabling ultra-sensitive (1 ng/spot) detection of antimicrobial compounds and rapidly advancing drug discovery!
pubs.acs.org/doi/10.1021/...
High-Frequency Microfluidic Fractionation for Compound-Resolved Bioactivity-Based Metabolomics
Specialized metabolites represent a prolific source of potential drug candidates. However, the process from detecting bioactivity in a crude metabolite extract to unambiguously identifying the active ...
pubs.acs.org
November 2, 2025 at 2:27 AM
Reposted by Sachin Sejuwal
(ACS Anal Chem) [ASAP] Practical Guidance for Training Machine Learning Models in Metabolomics and Mass Spectrometry Research: Analytical ChemistryDOI: 10.1021/acs.analchem.5c01417 #MassSpecRSS #ACSAChem
[ASAP] Practical Guidance for Training Machine Learning Models in Metabolomics and Mass Spectrometry Research
Analytical ChemistryDOI: 10.1021/acs.analchem.5c01417
dlvr.it
October 19, 2025 at 12:01 AM
Reposted by Sachin Sejuwal
(RSC A Meth) Demonstrating the application of a liquid chromatography-mass spectrometry method for the determination of phthalate diesters in complex solid and liquid environmental samples: Anal. Methods, 2025, Advance Article
DOI: 10.1039/D5AY01057H, Paper Open Access   This… #MassSpecRSS
Demonstrating the application of a liquid chromatography-mass spectrometry method for the determination of phthalate diesters in complex solid and liquid environmental samples
Anal. Methods, 2025, Advance Article DOI: 10.1039/D5AY01057H, Paper Open Access &nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Fiona Regan, Catherine Allen, Jenny Lawler A sensitive contaminantion-controled LC-MS/MS workflow quantifies 11 phthalate diesters in environmental samples with sub ng L−1 limits. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
dlvr.it
October 16, 2025 at 5:04 AM
Reposted by Sachin Sejuwal
🧪As we celebrate Nobel week, we do not forget the Nobel’s ugly twin, the Ig Nobel: this story is about bats getting a DUI, or rather an FUI🦇🥃

www.lbscience.org/en/2025/10/0...

@lbscience.org
Drunk Bats - Little, Big Science
In nature, alcohol isn’t found in pubs—it’s found in fruit. As fruit ripens, microorganisms ferment its sugars and generate ethanol, the type of alcohol found in intoxicating beverages (the same proce...
www.lbscience.org
October 7, 2025 at 11:46 PM
This finding is very interesting :)
Video: a Japanese scientist was attacked by flies while giving the acceptance speech for his Ig Nobel Prize-winning research paper that proved painting Zebra-like stripes on cows led to a decrease in biting fly attacks.
October 8, 2025 at 2:38 PM
Reposted by Sachin Sejuwal
Susumu Kitagawa, Richard Robson and Omar Yaghi are this year's winners of the Nobel prize in chemistry for their work on MOFs – just a few grams of these materials can have the same surface area as a football pitch. Julia Robinson with the details.
2025 chemistry Nobel prize goes to the scientists behind metal–organic frameworks
Susumu Kitagawa, Richard Robson and Omar Yaghi take top prize for discovery and development of versatile materials with a huge surface area
www.chemistryworld.com
October 8, 2025 at 12:05 PM
Reposted by Sachin Sejuwal
The 2025 Nobel prize in chemistry as it happens – live #Science #Chemistry #NobelPrize2025 #ChemistryNews #LiveUpdates
The 2025 Nobel prize in chemistry as it happens – live
Join us as we provide analysis and commentary in the run up to the announcement of the biggest prize in chemistry
purescience.news
October 8, 2025 at 12:00 PM
Reposted by Sachin Sejuwal
‘Surprisingly creamy’: as a fermentista, how could I resist making ant yoghurt?
‘Surprisingly creamy’: as a fermentista, how could I resist making ant yoghurt?
Findings of study into fermentation process behind dairy product could serve as toolkit for creating new foods
www.theguardian.com
October 3, 2025 at 11:50 PM
Chemistree 😃
August 6, 2025 at 5:29 PM
Reposted by Sachin Sejuwal
cooking is like the art of chemistry. taking different static elements and creating a nutritious, useful, and delicious product. inspiration comes from natural beauty and human need. Synthesis BABY
April 3, 2025 at 11:50 PM
Reposted by Sachin Sejuwal
Reposted by Sachin Sejuwal
It´s all about fungi!
Chalciporus rubinus
#fungifriends #mycology
July 30, 2025 at 12:33 AM
Reposted by Sachin Sejuwal
Reposted by Sachin Sejuwal
The first time Chris Nawrat found organic chemistry fascinating was in a third year undergraduate course on natural products. Amongst stories about beautiful molecules and legendary scientists who jockeyed to understand and eventually make them, he was hooked. #ChemSky
(–)-Bipinnatin J
A stepping stone to greater things?
www.chemistryworld.com
June 25, 2025 at 2:13 PM
Reposted by Sachin Sejuwal
July 30, 2025 at 8:08 PM
Reposted by Sachin Sejuwal
Join the online course on Bioinformatic Analysis of Transposable Elements from Nov 3-7. No prior TE experience needed. More info: https://www.physalia-courses.org/courses-workshops/course24/ #course
Bioinformatic analysis of Transposable Elements
3rd-7th November 2025 To foster international participation, this course will be held online
www.physalia-courses.org
July 29, 2025 at 1:23 PM