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sadikbay.bsky.social
@sadikbay.bsky.social
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Reposted
chiosislabmskcc.bsky.social
📸OUT NOW in JoVE Journal: Mapping Dysfunctional Protein-Protein Interactions in Disease.
Our method article is available now with video component coming soon!
app.jove.com/t/69197
#PPI #networkbiology #cancerbiology #dfPPI #MassSpectrometry #Proteomics
Mapping Dysfunctional Protein-Protein Interactions in Disease
Memorial Sloan Kettering Cancer Center. Here, we present a protocol to enable the capture and identification of disease-specific protein-protein interactions from native cells and tissues using chemi...
app.jove.com
October 30, 2025 at 8:32 PM
Reposted
cp-trendsbiochem.bsky.social
📢 Our October issue is now online. Access the full issue 👉 www.cell.com/trends/bioch....

🎨 The cover highlights a Review from @chiosislabmskcc.bsky.social‬ and co on how PTMs reprogram chaperones into epichaperomes.
October 6, 2025 at 2:40 PM
Reposted
chiosislabmskcc.bsky.social
📸Check out a few photos from @gabrielachiosis.bsky.social and Tanaya's talks at #CSSI2025 @stresscell.bsky.social l last weekend.
#epichaperome #cellularstress #HSP90 #Alzheimers
October 10, 2025 at 2:49 PM
Reposted
chiosislabmskcc.bsky.social
Dive deeper into our @cp-trendsbiochem.bsky.social cover article! Read more on @springernature.com Communities:
communities.springernature.com/posts/when-m...
#Epichaperome #PTMs #NetworkBiology #SystemsBiology #TrendsBiochem #NatureCommunities
When Modifications Rewrite Networks: How PTMs Reprogram Chaperones into Epichaperomes
communities.springernature.com
October 10, 2025 at 2:51 PM
Reposted
chiosislabmskcc.bsky.social
🚨Publication alert! The final version of our cover feature article is OUT NOW in @cp-trendsbiochem.bsky.social

Read how we connect the #epichaperome with the #chaperone code.

#PTMs #HSP90 #PPI #neuroscience #NetworkBiology
Check out the review article here: www.sciencedirect.com/science/arti...
PTMs as molecular encoders: reprogramming chaperones into epichaperomes for network control in disease
Recent discoveries reveal that post-translational modifications (PTMs) do more than regulate protein activity – they encode conformational states that…
www.sciencedirect.com
October 14, 2025 at 4:56 PM
Reposted
chiosislabmskcc.bsky.social
Sahil presented earlier this month at #AAIC2025 in Toronto @alzassociation.bsky.social
This work was supported by BrightFocus & NIH Aging and aims to advance #precisionmedicine in #neurodegeneration through the development of small molecule probes for #epichaperome imaging in #Alzheimers.
August 14, 2025 at 6:33 PM
Reposted
chiosislabmskcc.bsky.social
To know more about this strange and intriguing case check out our work linked below (8/8)
#phosphorylation #epichaperome #cancer #conformation #cellstress
www.nature.com/articles/s41...
Phosphorylation-driven epichaperome assembly is a regulator of cellular adaptability and proliferation - Nature Communications
Epichaperomes are chaperone assemblies that reorganize protein networks under stress. Here, authors reveal how HSP90 phosphorylation drives epichaperome formation, linking this process to cancer cell ...
www.nature.com
May 7, 2025 at 6:45 PM
Reposted
chiosislabmskcc.bsky.social
In #cancer, Casein Kinase 2 (CK2) interacts with #HSP90 and puts phosphate groups on Serine 255 and Serine 226 positions of the charged linker region of HSP90 thereby changing its structure or conformation. This dangerous alter ego of HSP90 helps the cancer cells to survive. (7)
#phosphorylation
May 7, 2025 at 6:45 PM
Reposted
chiosislabmskcc.bsky.social
🧵Follow this thread by Dr. Tanaya Roychowdhury to learn about the intriguing case of #HSP90 - adapted from our recent publication in @natcomms.nature.com (1/8)

#cancer #phosphorylation #epichaperome #conformation #cellstress

www.nature.com/articles/s41...
Phosphorylation-driven epichaperome assembly is a regulator of cellular adaptability and proliferation - Nature Communications
Epichaperomes are chaperone assemblies that reorganize protein networks under stress. Here, authors reveal how HSP90 phosphorylation drives epichaperome formation, linking this process to cancer cell ...
www.nature.com
May 7, 2025 at 6:45 PM
Reposted
chiosislabmskcc.bsky.social
🌐 The open-access dfPPI Platform lets researchers worldwide visualize and analyze dfPPI data interactively, empowering researchers with access to cutting-edge proteomics analysis. #OpenScience #Proteomics
April 25, 2025 at 3:11 PM
Reposted
chiosislabmskcc.bsky.social
🚀 Integrating dfPPI with other omics could reveal comprehensive disease mechanisms, paving the way for groundbreaking discoveries and precision therapeutics across numerous diseases. #MultiOmics #FutureResearch (11/11)
April 25, 2025 at 3:11 PM
Reposted
chiosislabmskcc.bsky.social
🧵Have you checked out our recent article in
Current Opinion in Structural Biology? Follow this thread by Chiosis Lab postdoc Souparna Chakrabarty
to learn about the Dysfunctional Protein-Protein Interactome (#dfPPI) - a #chemoproteomic platform www.sciencedirect.com/science/arti... 🧵(1/11)
Introducing dysfunctional Protein-Protein Interactome (dfPPI) – A platform for systems-level protein-protein interaction (PPI) dysfunction investigation in disease
Protein-protein interactions (PPIs) play a crucial role in cellular function and disease manifestation, with dysfunctions in PPI networks providing a …
www.sciencedirect.com
April 25, 2025 at 3:11 PM
Reposted
chiosislabmskcc.bsky.social
Accepted manuscript alert! Our review "#Epichaperomes: Redefining #ChaperoneBiology and Therapeutic Strategies in Complex Diseases" is now out in @rscchembio.rsc.org #DrugDiscovery #NetworkMedicine #SystemsBiology #PrecisionTherapeutics pubs.rsc.org/en/content/a...
Epichaperomes: redefining chaperone biology and therapeutic strategies in complex diseases
The complexity of disease biology extends beyond mutations or overexpression, encompassing stress-induced mechanisms that reshape proteins into pathological assemblies. Epichaperomes, stable and disea...
pubs.rsc.org
March 25, 2025 at 8:29 PM
Reposted
chiosislabmskcc.bsky.social
Earlier this month Chiosis Lab postdoc Souparna presented at #cshlnetworks on the #dfPPI platform, a powerful #Chemoproteomics tool to decode stressor-induced #ProteinNetworks dysfunctions in #CancerResearch & #NeurodegenerativeDiseases 🧠👨‍💻
🎊Congrats on your talk Souparna! @cshlmeetings.bsky.social
March 27, 2025 at 4:52 PM
Reposted
gabrielachiosis.bsky.social
How do stressors remodel #brain function before symptoms emerge? &network-centric intervention strategies as a promising avenue for disease-modifying #therapy in AD
#Alzheimers #epichaperomes #neuroscience #SystemsBiology #networkbiology #drugdiscovery
www.researchsquare.com/article/rs-5...
Systems-Level Interactome Mapping Reveals Actionable Protein Network Dysregulation Across the Alzheimer's Disease Spectrum
Alzheimer’s disease (AD) progresses as a continuum, from preclinical stages to late-stage cognitive decline, yet the molecular mechanisms driving this progression remain poorly understood. Here, we pr...
www.researchsquare.com
March 3, 2025 at 5:36 PM
Reposted
chiosislabmskcc.bsky.social
💫Preprint available now! Our most recent research on #Alzheimers and #epichaperomes is below. Read to find out how #epichaperomes are key mediators of molecular collapse in #AD & what avenues are promising for disease-modifying #therapies🧠
www.researchsquare.com/article/rs-5...
Systems-Level Interactome Mapping Reveals Actionable Protein Network Dysregulation Across the Alzheimer's Disease Spectrum
Alzheimer’s disease (AD) progresses as a continuum, from preclinical stages to late-stage cognitive decline, yet the molecular mechanisms driving this progression remain poorly understood. Here, we pr...
www.researchsquare.com
February 24, 2025 at 3:09 PM
Reposted
gabrielachiosis.bsky.social
🧠Beyond the Headlines: Ensuring Integrity While Advancing #Alzheimers Research
Sensational headlines aren’t the answer. Accountability matters—but so does celebrating the #science driving real solutions. communities.springernature.com/posts/beyond...
#Neurodegeneration #journalism #news
Beyond the Headlines: Ensuring Integrity While Advancing Alzheimer’s Research
How do we ensure scientific integrity while advancing urgently needed treatments? Sensationalized media narratives aren’t the answer. While accountability is essential, we must also recognize the grou...
communities.springernature.com
February 21, 2025 at 4:41 PM
Reposted
chiosislabmskcc.bsky.social
How do stressors remodel brain function before symptoms emerge?
💫Preprint live now - our most recent research on #Alzheimers & #epichaperomes! Find out how #epichaperomes are key mediators of molecular collapse in #AD & what #therapeutic avenues may be open 🧠
www.researchsquare.com/article/rs-5...
Systems-Level Interactome Mapping Reveals Actionable Protein Network Dysregulation Across the Alzheimer's Disease Spectrum
Alzheimer’s disease (AD) progresses as a continuum, from preclinical stages to late-stage cognitive decline, yet the molecular mechanisms driving this progression remain poorly understood. Here, we pr...
www.researchsquare.com
February 19, 2025 at 3:18 PM
Reposted
gabrielachiosis.bsky.social
🧠✨ "How do stressors remodel brain function before symptoms emerge?"
Check out researchsquare.com/article/rs-5... exploring how progressive protein network miswiring drives #Alzheimer disease—and how these changes can be reversed. #Neuroscience #Network #SystemsBiology
Systems-Level Interactome Mapping Reveals Actionable Protein Network Dysregulation Across the Alzheimer's Disease Spectrum
Alzheimer’s disease (AD) progresses as a continuum, from preclinical stages to late-stage cognitive decline, yet the molecular mechanisms driving this progression remain poorly understood. Here, we pr...
researchsquare.com
February 19, 2025 at 2:00 PM