@sagnera.bsky.social
Reposted
Excited to share @rbrianroome.bsky.social ‘s beautiful paper on development of the dorsal horn of the mouse spinal cord @science.org
This is how the anatomical organization and cell types that process pain, touch, body position and more are laid down.
www.science.org/doi/10.1126/...
This is how the anatomical organization and cell types that process pain, touch, body position and more are laid down.
www.science.org/doi/10.1126/...
Ontogeny of the spinal cord dorsal horn
The dorsal horn of the mammalian spinal cord is organized into laminae where each layer is populated by different neuron types, has distinctive circuit connections, and plays specialized roles in beha...
www.science.org
January 8, 2026 at 7:59 PM
Excited to share @rbrianroome.bsky.social ‘s beautiful paper on development of the dorsal horn of the mouse spinal cord @science.org
This is how the anatomical organization and cell types that process pain, touch, body position and more are laid down.
www.science.org/doi/10.1126/...
This is how the anatomical organization and cell types that process pain, touch, body position and more are laid down.
www.science.org/doi/10.1126/...
Reposted
Good to see the peer reviewed version of this published
A chemo-optogenetic system for spatiotemporal control of gene expression
We use it to:
- Reconstruct SHH mediated neural tube patterning in vitro
- Measure extracellular half-life of Shh
www.cell.com/developmenta...
A chemo-optogenetic system for spatiotemporal control of gene expression
We use it to:
- Reconstruct SHH mediated neural tube patterning in vitro
- Measure extracellular half-life of Shh
www.cell.com/developmenta...
Investigating morphogen and patterning dynamics with optogenetic control of morphogen production
Benzinger et al. develop a chemo-optogenetic system for precise spatiotemporal control
of morphogen production in vitro. Using light-controlled Sonic hedgehog expression,
they recapitulate neural tube...
www.cell.com
December 16, 2025 at 1:45 AM
Good to see the peer reviewed version of this published
A chemo-optogenetic system for spatiotemporal control of gene expression
We use it to:
- Reconstruct SHH mediated neural tube patterning in vitro
- Measure extracellular half-life of Shh
www.cell.com/developmenta...
A chemo-optogenetic system for spatiotemporal control of gene expression
We use it to:
- Reconstruct SHH mediated neural tube patterning in vitro
- Measure extracellular half-life of Shh
www.cell.com/developmenta...
Reposted
Ten days left to apply to be a @crick.ac.uk Early Career Group Leader
Closing date 27th November
www.crick.ac.uk/careers-stud...
Closing date 27th November
www.crick.ac.uk/careers-stud...
November 17, 2025 at 11:55 AM
Ten days left to apply to be a @crick.ac.uk Early Career Group Leader
Closing date 27th November
www.crick.ac.uk/careers-stud...
Closing date 27th November
www.crick.ac.uk/careers-stud...
Reposted
How do pleiotropic TFs generate organized diversity in developing tissues? @spinalorga.bsky.social shows that PAX3 & PAX7 organize #SpinalCord by acting as both repressors & pioneer activators, regulated by #morphogens to ensure precise neural subtype specification @plosbiology.org 🧪 plos.io/4qumsla
October 27, 2025 at 5:25 PM
How do pleiotropic TFs generate organized diversity in developing tissues? @spinalorga.bsky.social shows that PAX3 & PAX7 organize #SpinalCord by acting as both repressors & pioneer activators, regulated by #morphogens to ensure precise neural subtype specification @plosbiology.org 🧪 plos.io/4qumsla
Reposted
Our latest: *Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding*
For a summary & the digested highlights see thread🧵 from @giulia-boezio.bsky.social
www.biorxiv.org/content/10.1...
For a summary & the digested highlights see thread🧵 from @giulia-boezio.bsky.social
www.biorxiv.org/content/10.1...
October 27, 2025 at 8:50 AM
Our latest: *Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding*
For a summary & the digested highlights see thread🧵 from @giulia-boezio.bsky.social
www.biorxiv.org/content/10.1...
For a summary & the digested highlights see thread🧵 from @giulia-boezio.bsky.social
www.biorxiv.org/content/10.1...
Reposted
Are you enthusiastic about stem cell biology and developmental biology and looking to start a PhD in 2026? Funded opportunites now available. Contact for more infomation. Links below! @lovegrovelab.bsky.social @veronicabiga.bsky.social @manchester.ac.uk @ukri.org
October 9, 2025 at 4:21 PM
Are you enthusiastic about stem cell biology and developmental biology and looking to start a PhD in 2026? Funded opportunites now available. Contact for more infomation. Links below! @lovegrovelab.bsky.social @veronicabiga.bsky.social @manchester.ac.uk @ukri.org
Reposted
Just published: The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube
A global temporal chromatin program, operating across the CNS, directs binding of specific spatial TFs & hence when/where neurons & glia are born
authors.elsevier.com/sd/article/S...
A global temporal chromatin program, operating across the CNS, directs binding of specific spatial TFs & hence when/where neurons & glia are born
authors.elsevier.com/sd/article/S...
ScienceDirect.com | Science, health and medical journals, full text articles and books.
authors.elsevier.com
July 17, 2025 at 10:07 AM
Just published: The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube
A global temporal chromatin program, operating across the CNS, directs binding of specific spatial TFs & hence when/where neurons & glia are born
authors.elsevier.com/sd/article/S...
A global temporal chromatin program, operating across the CNS, directs binding of specific spatial TFs & hence when/where neurons & glia are born
authors.elsevier.com/sd/article/S...
Reposted
Our latest "Dynamic Landscape Analysis of Cell Fate Decisions: Predictive Models of Neural Development From Single-Cell Data"
A rigorous mathematical foundation for Waddington's landscape to study cell fate decision making
Applied to ventral neural tube development
www.biorxiv.org/content/10.1...
A rigorous mathematical foundation for Waddington's landscape to study cell fate decision making
Applied to ventral neural tube development
www.biorxiv.org/content/10.1...
Dynamic Landscape Analysis of Cell Fate Decisions: Predictive Models of Neural Development From Single-Cell Data
Building a mechanistic understanding of cell fate decisions remains a fundamental goal of developmental biology, with implications for stem cell therapies, regenerative medicine and understanding dise...
www.biorxiv.org
May 29, 2025 at 12:08 PM
Our latest "Dynamic Landscape Analysis of Cell Fate Decisions: Predictive Models of Neural Development From Single-Cell Data"
A rigorous mathematical foundation for Waddington's landscape to study cell fate decision making
Applied to ventral neural tube development
www.biorxiv.org/content/10.1...
A rigorous mathematical foundation for Waddington's landscape to study cell fate decision making
Applied to ventral neural tube development
www.biorxiv.org/content/10.1...
First preprint from the lab!
Expression of 3 TFs - Onecut2, Pou2f2 and Pou3f1 - in sequentially generated neurons correlates with and is functionally required for the correct specification of neuronal subtypes mediating spinal sensory and motor output!
www.biorxiv.org/content/10.1...
Expression of 3 TFs - Onecut2, Pou2f2 and Pou3f1 - in sequentially generated neurons correlates with and is functionally required for the correct specification of neuronal subtypes mediating spinal sensory and motor output!
www.biorxiv.org/content/10.1...
www.biorxiv.org
May 29, 2025 at 11:56 AM
First preprint from the lab!
Expression of 3 TFs - Onecut2, Pou2f2 and Pou3f1 - in sequentially generated neurons correlates with and is functionally required for the correct specification of neuronal subtypes mediating spinal sensory and motor output!
www.biorxiv.org/content/10.1...
Expression of 3 TFs - Onecut2, Pou2f2 and Pou3f1 - in sequentially generated neurons correlates with and is functionally required for the correct specification of neuronal subtypes mediating spinal sensory and motor output!
www.biorxiv.org/content/10.1...
Reposted
Beautiful work from @sagnera.bsky.social & co on how spinal neurons diversify
A temporal TF clock in spinal neurons, sequentially specifying different motor and sensory neuron subtypes during development
A shared molecular timer driving cellular diversity
www.biorxiv.org/cgi/content/...
A temporal TF clock in spinal neurons, sequentially specifying different motor and sensory neuron subtypes during development
A shared molecular timer driving cellular diversity
www.biorxiv.org/cgi/content/...
www.biorxiv.org
May 29, 2025 at 6:29 AM
Beautiful work from @sagnera.bsky.social & co on how spinal neurons diversify
A temporal TF clock in spinal neurons, sequentially specifying different motor and sensory neuron subtypes during development
A shared molecular timer driving cellular diversity
www.biorxiv.org/cgi/content/...
A temporal TF clock in spinal neurons, sequentially specifying different motor and sensory neuron subtypes during development
A shared molecular timer driving cellular diversity
www.biorxiv.org/cgi/content/...