Krishanu Saha
@sahakris.bsky.social
210 followers 390 following 200 posts
Professor at Univ. of Wisconsin-Madison (@WIDiscovery @HoltzCenter @Forward_BIO @UWMadGIE) + Genome Editor (@somaticediting) + Cell Bioengineer (@CMaT_ERC)
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sahakris.bsky.social
Thrilled to highlight the brilliant work by Mandana Arbab, Zaneta Matuszek, with the Mouro Pinto and Liu labs — another major leap forward for somatic cell gene editing. 👏🧬
Base editing as a therapeutic strategy for repeat expansion diseases
@NatureGenet
nature.com/articles/s41...
https://nature.com/articles/s41588-025-02201-6…
sahakris.bsky.social
@laurensarko.bsky.social gave a great talk at #ASGCT2025:
CRISPR-engineered CAR T cells targeting senescence-associated uPAR

Clear, compelling science—and a great discussion that followed. Exciting to see where this work is headed.

#CRISPR #CellTherapy
@warfnews.bsky.social
sahakris.bsky.social
Looking forward to this timely Scientific Symposium and conversation on #CRISPR #GeneEditing at #ASGCT2025!
“Who’s Afraid of Off-Target Editing?”
1:30–3:15 PM CT (Room 293–296)
With Claire Clelland (UCSF) & Kiran Musunuru (Penn) of
@somaticediting Join us! #GenomicMedicine
Reposted by Krishanu Saha
widofficial.bsky.social
Proud to have you represent!
sahakris.bsky.social
🌍 Excited to join the @UWMadison delegation in India for Badger Utsav II! We'll celebrate the opening of @BharatBiotech’s new gene & cell therapy facility. Grateful for this opportunity to connect & collaborate.
#CRISPR

ghi.wisc.edu/science-is-g...
Science is Global: Building Bridges with Dr. Kris Saha – Global Health Institute
ghi.wisc.edu
Reposted by Krishanu Saha
widofficial.bsky.social
Congrats to Giulia Scimonelli from the @sahakris.bsky.social Lab. The research award, funded by grants from Brittingham Wisconsin Trust, Knapp Bequest, and UW Division for Teaching and Learning, allows her to study T Cell Phenotype Enrichment Through mRNA Delivery for Enhanced CAR-T Manufacturing.
sahakris.bsky.social
🌍 Excited to join the @UWMadison delegation in India for Badger Utsav II! We'll celebrate the opening of @BharatBiotech’s new gene & cell therapy facility. Grateful for this opportunity to connect & collaborate.
#CRISPR

ghi.wisc.edu/science-is-g...
Science is Global: Building Bridges with Dr. Kris Saha – Global Health Institute
ghi.wisc.edu
sahakris.bsky.social
🎉 Huge congrats to our newest PhD, Dr. Khajanchi (@omgitsnamita), on her stellar defense! 🌟 She delivered an outstanding presentation on her groundbreaking work developing a tunable #CRISPR genome editing system in human cells. Stay tuned for the preprint! 📄👏
sahakris.bsky.social
🎓 Today at 10 am CT, join us at the DeLuca Forum or online for @omgitsnamita’s PhD defense on “Regulating Cas9 Genome Editor with Small Molecule Drugs.” 🌟

📍 @DiscoveryBldg
🔗 DM for Zoom link!
#CRISPR
sahakris.bsky.social
Please join me in congratulating @Shankar_K2, Ph.D. on her thesis defense! 🎓 By integrating #CRISPR genome editing w/ cell engineering, Dr. Shankar has crafted programmable cell therapies that are foundational to our lab’s new directions. @CMaT_ERC @UWCarbone @UWMadison_BME
sahakris.bsky.social
Two PhD defenses this week: Join us! Orchard View, 3280, @WIDiscovery:

@dcapps123 5/14: 2pm, Towards Efficient and Scalable Manufacturing of Genome-Edited CRISPR CAR T Cells

@Shankar_K2 5/16: 2pm, Development of human natural killer cell-based immunotherapies via genome eng.
sahakris.bsky.social
At #ASGCT2024, we're showcasing advances in non-viral gene editing, CAR T cell therapies, & high-throughput screening. Explore our work on vision restoration, cancer therapy, and ethical challenges in the field. Join us to learn about the latest progress in #GeneTherapy research
sahakris.bsky.social
Join us this Thursday, Mar 21!
A Question of Beginnings: Lab Embryos Between Nature and Synthesis
with @jacob_hanna, @cartersnead, @ArnoldEisen, @SJasanoff, @JudyNorsigian, @jdhardin1959 + many more.

@GenomeObserv

Registration:
sahakris.bsky.social
More momentum for CRISPR drugs! This time, it’s through direct injection of nanoparticles into the body.
sahakris.bsky.social
Learn about the first approved #CRISPR drug and our own efforts to build on this breakthrough...tomorrow morning @WPR at 7:30am Central. Call in with your questions: 800-642-1234 @WIDiscovery @uwsmph @UWMadEngr @somaticediting @CMaT_ERC
sahakris.bsky.social
The first authorized medicine for the #CRISPR field! The US FDA decision is likely to come next month. We are all hoping that post-market/approval data is shared and the durability of efficacy is at least many years, as seen in the clinical trials. ⁦
sahakris.bsky.social
Finding resonance with many others thinking about global governance of emerging tech here at the #ParisPeaceForum2023. Come see our roundtable discussion on #CRISPR genome editing tomorrow.
sahakris.bsky.social
It’s been a joy to develop & teach this hands-on #CRISPR lab course for @UWMadEngr. Read about our journey here. Our teaching assistants - Jamie, Anna, and @smerchette - provided invaluable input, and the students are quickly becoming expert gene editors!
sahakris.bsky.social
Here is an excellent and ongoing discussion of a #CRISPR gene-edited cell therapy on the brink of approval. An important guidepost for our in vivo somatic editing efforts @somaticediting
sahakris.bsky.social
Congratulations to all the 2023 JITC Best Paper Award Recipients! Especially to former Ph.D. students in our @UWMadison lab: @kpmueller1 + @NicoleJPiscopo (w/@CapitiniMD @UWCarbone @CMaT_ERC) for Best Immune Cell Therapies & Immune Cell Engineering Paper
sahakris.bsky.social
We are hiring! Join the UW-Madison Biomedical Engineering department as a faculty member in a vibrant research community. 👇
sahakris.bsky.social
The ecosystem for biotech here in Madison and Wisconsin is on the rise… @UWCarbone @UWMadison @Forward_BIO
sahakris.bsky.social
Our new @somaticediting article describing an unexpected distribution of #CRISPR genome editing in the brain. These new delivery vectors can travel in surprising ways within tissues after injection. With Emborg, Levine, @GongShaoqin @uwsmph @UWMadEngr