Delayed brain aging associated with adherence to lifestyle and health risk factors www.thelancet.com/journals/ebi...

Discovery of a gut hormone that regulates protein intake, sleep, and influences lifespan
www.nature.com/articles/s42... (open-access) @natmetabolism.nature.com
www.nature.com/articles/s42... in mice and flies

New @science.org
Hedonic eating (eating for pleasure, not need) is mediated by dopamine neurons (in the brain ventral segmental area, VTA) and they are antagonized by GLP-1 drugs, such as semaglutide, leading to weight loss
www.science.org/doi/10.1126/...

How does exercise and fitness promote healthy brain aging?
An outstanding, comprehensive review @thelancet.bsky.social
reduced neuroinflammmation, preserves blood-brain-barrier, neurogenesis, role of exerkines, and much more
www.thelancet.com/journals/lan...

Discovery of a new class of natural antibiotics with a new mode of action to address antimicrobial resistance, a major unmet need
@mcmasteruniversity.bsky.social
@nature.com
www.nature.com/articles/s41...

As we age, we accumulate somatic mutations in our cells (mutation clock) and DNA methylation changes (epigenetic clock). They correlate and interact
www.nature.com/articles/s43...

Great opportunity for experienced cancer biology drug discovery leaders 📣📣📣

Quite an essay on the basis of cancer entitled "The End of the Genetic Paradigm of Cancer" @plosbiology.org arguing against the primacy of somatic mutations (traditional model) and cells, invoking gene regulatory networks and tissue
journals.plos.org/plosbiology/...

A new study revealed the presence of microplastics – tiny fragments of degraded plastic – in human brain tissue. While previous research has identified microplastics in the liver, kidneys, and placenta, this suggests that the brain may be especially vulnerable to these tiny synthetic particles.

The first comprehensive atlas of allele-specific DNA methylation
www.nature.com/articles/s41...

🌟🌟🌟 Join our cancer drug discovery team in London-Sutton! 🌟🌟🌟
We’re looking for a passionate biologist eager to drive innovation in targeted protein degradation and cancer drug discovery. If you’re seeking to make a real impact, we would love to hear from you! #CancerResearch #DrugDiscovery
#ICR

The X-chromosome and impact on the brain's structure and functionality between sexes, from >38,000 UK Biobank participants and >1,000 MRI imaging traits, noting extent of X-inactivation (=DC-dosage compensation)
www.science.org/doi/10.1126/... open-access

We're pleased that National Institute for Health and Care Excellence (NICE) have recommended that olaparib can be used for NHS patients with advanced #BreastCancer.

Read more here ⬇️

icr.ac.uk/about-us/icr-news/detail/icr-welcomes-nice-recommendation-of-olaparib-for-advanced-breast-cancer

Cardiorespiratory fitness overrides BMI for association with reduced all-cause and cardiovascular mortality, results from a systematic review of 20 studies
bjsm.bmj.com/content/earl...
www.washingtonpost.com/wellness/202...

The gut microbiome signature from different diets in 20,000 individuals. Red meat intake correlated with reduced cardiometabolic health; the opposite for plant-based foods or in omnivores with enriched plant-based intake
www.nature.com/articles/s41...

Israel nearly killed the head of the World Health Organization.

Has any Western government commented on this yet? Can you imagine their response if it was Iran or Russia?