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Conceicao Bettencourt @saobettencourt.bsky.social · 1d

Interested in #epigenetics #DNAmethylation #omics #Dementia #oligodendrocytes? Join us tomorrow👇

Conceicao Bettencourt @saobettencourt.bsky.social · 6d

🚨Join our next @DEMONNetworkUK #Genetics and #Omics meeting on THURSDAY 9th October at 2.30 PM (UK Time). Delighted to have Kate Fodder‬ as invited speaker – “Early #oligodendrocyte dysfunction signature in #Alzheimer’s disease: Insights from DNA #methylomics and #transcriptomics”.
DM for more info

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Conceicao Bettencourt @saobettencourt.bsky.social · 6d

🚨Join our next @DEMONNetworkUK #Genetics and #Omics meeting on THURSDAY 9th October at 2.30 PM (UK Time). Delighted to have Kate Fodder‬ as invited speaker – “Early #oligodendrocyte dysfunction signature in #Alzheimer’s disease: Insights from DNA #methylomics and #transcriptomics”.
DM for more info

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Conceicao Bettencourt @saobettencourt.bsky.social · 16d

Thanks 🙂! @chiesascott.bsky.social

Conceicao Bettencourt @saobettencourt.bsky.social · 16d

Many thanks 🙂! @sproullab.bsky.social

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Conceicao Bettencourt @saobettencourt.bsky.social · 16d

Last week, I had the honour to deliver my @uclqsion.bsky.social professorial inaugural lecture. A memorable occasion to reflect about my career and thank amazing people who supported me in many ways. I look forward to exciting research ahead!
#epigenetics #omics #neurodegeneration #dementia #ageing

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Conceicao Bettencourt @saobettencourt.bsky.social · 22d

Thank you @alzheimersresearchuk.org for all your support 🫶

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Reposted by Conceicao Bettencourt

Conceicao Bettencourt @saobettencourt.bsky.social · Aug 27

🚨Join our next @DEMONNetworkUK #Genetics and #Omics meeting on THURSDAY 11th September at 2.30 PM (UK Time). Delighted to have @jclambert.bsky.social‬ as invited speaker – “From #GWAS to polygenic risk scores in #Alzheimer's disease”

Join the network or DM for more info

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Conceicao Bettencourt @saobettencourt.bsky.social · Aug 27

🚨Join our next @DEMONNetworkUK #Genetics and #Omics meeting on THURSDAY 11th September at 2.30 PM (UK Time). Delighted to have @jclambert.bsky.social‬ as invited speaker – “From #GWAS to polygenic risk scores in #Alzheimer's disease”

Join the network or DM for more info

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Reposted by Conceicao Bettencourt

Front Line Genomics @flgenomics.bsky.social · Jul 15

#Multiomics approaches are enabling the decoding of the impact of non-coding variants and of disease-associated molecular dysregulation. Hear from @saobettencourt.bsky.social and Andrew Stergachis TODAY in Webinar 1 of the Multi-Omics Online series. Register now: hubs.la/Q03wC2FL0

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Reposted by Conceicao Bettencourt

Selina Wray @selinawray.bsky.social · Jul 14

UCL Queen Square Institute of Neurology ready to (platform) party this morning! @uclqsion.bsky.social

Huge congratulations to all of our graduates from the @uclbrainscience.bsky.social & wishing you all every success for the future! #UCLgrad

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Reposted by Conceicao Bettencourt

Front Line Genomics @flgenomics.bsky.social · Jul 10

Discover how #multiomics is transforming disease research! Our new webinar series, Multi-Omics Online, showcases the latest advances from foundational science to clinical application. Register now to find out what’s working, what’s not, and what’s new.
Register here: hubs.la/Q03wC2D50

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Conceicao Bettencourt @saobettencourt.bsky.social · Jul 11

🚨New publication alert from the #BettencourtLab! Naiomi Rambarack's first first-author paper 👏 :
#DNAmethylation #dysregulation of #STX6 and other #FTLD #genetic risk-associated loci".

#Dementia

Big thanks to all contributors and funders!
@alzheimersresearchuk.org

rdcu.be/euZmw

DNA methylation as a contributor to dysregulation of STX6 and other frontotemporal Lobar degeneration genetic risk-associated loci

rdcu.be

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Conceicao Bettencourt @saobettencourt.bsky.social · Jul 8

🚨Join our next @Deep #Dementia Phenotyping (DEMON) Network #Genetics and #Omics meeting on THURSDAY 10th July at 2.30 PM (UK Time). Delighted to have @billingsleykj.bsky.social as invited speaker – “Decoding the Genomics of Neurodegenerative Diseases with Large-Scale Long-Read Sequencing”.

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Reposted by Conceicao Bettencourt

Selina Wray @selinawray.bsky.social · Jun 21

New paper from the lab, under the leadership of @celarber.bsky.social !

Molecular Neurodegeneration @molneurodegen.bsky.social · Jun 20

'Mutations in #PSEN1 predispose #inflammation in an #astrocyte model of familial #AlzheimersDisease through disrupted regulated intramembrane proteolysis'

Oliver J. Ziff... @selinawray.bsky.social & Charles Arber @uclqsion.bsky.social‬‬

molecularneurodegeneration.biomedcentral.com/articles/10....

Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer’s disease through disrupted regulated intramembrane proteolysis - Molecular Neurodegeneration

Background Mutations in PSEN1 cause familial Alzheimer’s disease with almost complete penetrance. Age at onset is highly variable between different PSEN1 mutations and even within families with the sa...

molecularneurodegeneration.biomedcentral.com

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Reposted by Conceicao Bettencourt

Emma Anderson @emmylooroll.bsky.social · Jun 11

External link live! Please share widely :-)

WE ARE RECRUITING! 🥳

Are you an epidemiologist with strong quantitative skills and an interest in contributing to exciting research into the genetic architecture of vascular dementia? Come join our friendly and productive team at UCL!

shorturl.at/aZ5Ua

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Conceicao Bettencourt @saobettencourt.bsky.social · Jun 9

Join our next @DEMONNetworkUK #Genetics and #Omics meeting on THURSDAY 12th June @2.30 PM (UK Time). Delighted to have María Beatriz Bistué Millón and Fulya Akcimen as invited speakers – “Characterization of short tandem repeat expansions in dementia across Latin American populations”.
DM for +info

Reposted by Conceicao Bettencourt

Mike Dolan @dolanmjg.bsky.social · Apr 28

How does the brain repair myelin after injury?

We mapped the full cellular choreography of white matter repair using snRNA-seq + Slide-seqv2, uncovering a type I interferon-driven glial program that recruits lymphocytes to promote remyelination.
www.biorxiv.org/content/10.1...

Details below 👇

Spatiotemporal Analysis of Remyelination Reveals a Concerted Interferon-Responsive Glial State That Coordinates Immune Infiltration

Remyelination, the process by which axons are re-encased in myelin after injury, is a critical step in restoring brain function, yet the dynamics from initial injury to repair remain poorly characteri...

www.biorxiv.org

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Conceicao Bettencourt @saobettencourt.bsky.social · Apr 21

Excited to be presenting our work on #Epigenomics of #Tauopathies and related diseases later this week at #Tau2025👇!

Alzheimer's Association @alzassociation.bsky.social · Feb 6

Join us along with The Rainwater Charitable Foundation and CurePSP for #Tau2025, Apr. 24-25 in London or online! Be a part of the conversation as leading experts work to address the future of tau research. Register now: alz.org/Tau

Tau Global Conference | Alzheimer’s Association

Leading experts from academia, industry, philanthropy and government will meet to address the future of tau research. Learn more and register.

alz.org

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Reposted by Conceicao Bettencourt

Niccoli Lab @niccolilab.bsky.social · Apr 8

Our paper just came out in Cell Reports, thank you to everyone that contributed! Differential neuronal vulnerability to C9orf72 repeat expansion driven by Xbp1-induced endoplasmic reticulum-associated degradation: Cell Reports www.cell.com/cell-reports...

Differential neuronal vulnerability to C9orf72 repeat expansion driven by Xbp1-induced endoplasmic reticulum-associated degradation

C9orf72 repeat expansion, a leading cause of ALS/FTD, triggers selective neuronal death. Using a Drosophila model, Shen et al. identified vulnerable and resistant neuronal populations. Resistance corr...

www.cell.com

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Conceicao Bettencourt @saobettencourt.bsky.social · Apr 3

🚨Join our next @DEMONNetworkUK #Genetics and #Omics meeting on THURSDAY 10th April at 2.30 PM (UK Time). Delighted to have Faraz Faghri as invited speaker – “AI for Discovery: Applications in #Biomedicine and #Brain #Health”.

Join the network or DM for more info

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Reposted by Conceicao Bettencourt

Dementia Researcher @dementiaresearcher.bsky.social · Mar 27

Dr Imre Lengyel @imrelengyel1963.bsky.social at Queen's University Belfast is seeking a PhD Student to explore 'Revolutionizing MS and Alzheimer’s Monitoring: The Role of Retinal Imaging in Understanding Disease Progression'. Closing date: 8th April

www.dementiaresearcher.nihr.ac.uk/job/phd-the-...

PhD: The Role of Retinal Imaging in Understanding Disease Progression

Dr Imre Lengyel at Queen's University Belfast is seeking a PhD Student to explore 'Revolutionizing Multiple Sclerosis and Alzheimer’s disease Monitoring: The Role of Retinal Imaging in Understanding D...

www.dementiaresearcher.nihr.ac.uk

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Conceicao Bettencourt @saobettencourt.bsky.social · Mar 21

🚨 It's been a very important day to the #BettencourtLab. Congratulations Dr Katherine Fodder 🥳🥂! Proud PhD supervisor here! It's been a pleasure to work with you during this journey. Thank you so much to both examiners Emma Dempster and Simon Mead ! ☺️

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Reposted by Conceicao Bettencourt

Jack Humphrey @jack-humphrey.bsky.social · Mar 17

www.biorxiv.org/content/10.1... New work from Humphrey and Raj labs, exploring the role of RNA editing in myeloid cells. Hopefully will be a useful resource for the field. Next stop: genetics!

Cytosine-to-uracil RNA editing is upregulated by pro-inflammatory stimulation of myeloid cells

Myeloid cells undergo large changes to their gene expression profile in response to inflammatory stimulation. This includes an increase in post-transcriptional modifications carried out by adenosine-t...

www.biorxiv.org

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Conceicao Bettencourt @saobettencourt.bsky.social · Mar 14

The #BettencourtLab had a great time at #Epigenomics25 🧬. Naiomi Rambarack, Katherine Fodder and Hannah Smith did an amazing job at presenting our work on #epigenetics of #dementias 🧠. It was great to network and get inspiration from experts from around the 🌎. #DNAmethylation #FTD #Alzheimers

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Eric Topol @erictopol.bsky.social · Mar 11

The first comprehensive atlas of allele-specific DNA methylation
www.nature.com/articles/s41...

Atlas of imprinted and allele-specific DNA methylation in the human body - Nature Communications

DNA methylation drives parental expression differences at imprinted genes. Here, the authors uncover hundreds of ubiquitous and tissue-specific differentially methylated regions, offering insights int...

www.nature.com

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