Sarah Naguib, PhD
@sarahnaguib.bsky.social
250 followers
700 following
2 posts
Postdoc in @liganlab.bluesky.social at Weill Cornell Medicine interested in resilience and microglia in neurodegeneration • Vanderbilt Neuro PhD ‘22 • Kenyon College ‘17 • 1st gen Egyptian-American
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Reposted by Sarah Naguib, PhD
Reposted by Sarah Naguib, PhD
John Lukens
@lukensjohnr.bsky.social
· Jul 10
Microglia replacement halts the progression of microgliopathy in mice and humans
Colony-stimulating factor 1 receptor (CSF1R) is primarily expressed in microglia. Its monoallelic mutation causes CSF1R-associated microgliopathy (CAMP), a major form of adult-onset leukoencephalopath...
www.science.org
Reposted by Sarah Naguib, PhD
Gan Lab
@liganlab.bsky.social
· Jun 24
The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway
The Christchurch mutation (R136S) in the APOE3 (E3S/S) gene is associated with attenuated tau load and cognitive decline despite the presence of a cau…
www.sciencedirect.com
Reposted by Sarah Naguib, PhD
Gan Lab
@liganlab.bsky.social
· Jun 24
The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway
The Christchurch mutation (R136S) in the APOE3 (E3S/S) gene is associated with attenuated tau load and cognitive decline despite the presence of a cau…
www.sciencedirect.com
Reposted by Sarah Naguib, PhD
Immunity
@cp-immunity.bsky.social
· Jun 23
The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway
The APOE3 Christchurch mutation (R136S) reduces tau pathology despite the PSEN1 mutation and high amyloid, though its protective mechanism remains unclear. Naguib et al. show that R136S suppresses microglial cGAS-STING-IFN signaling in tauopathy mice. Inhibiting cGAS preserves synapses and mimics R136S-linked gene expression, suggesting that cGAS suppression is a key part of the underlying protective effects of R136S.
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