Schuh Lab
@schuhlab.bsky.social
Illuminating the beginning of life at the Department of Meiosis, Max Planck Institute for Multidisciplinary Sciences @mpi-nat.bsky.social. Account managed by Melina and Vanessa @schuhlab.bsky.social
The Schuh lab just got a new postdoc—welcome Venus! 🎉
Venus studied telomere regulation in cancer during her PhD and will now explore telomeres in meiosis.
Excited to have you on the team, Venus! ✨
Venus studied telomere regulation in cancer during her PhD and will now explore telomeres in meiosis.
Excited to have you on the team, Venus! ✨
January 30, 2026 at 9:17 AM
The Schuh lab just got a new postdoc—welcome Venus! 🎉
Venus studied telomere regulation in cancer during her PhD and will now explore telomeres in meiosis.
Excited to have you on the team, Venus! ✨
Venus studied telomere regulation in cancer during her PhD and will now explore telomeres in meiosis.
Excited to have you on the team, Venus! ✨
🚀 Our research on human egg quality and #fertility is making headlines worldwide! 🌍
Thanks to @debojitsaha.bsky.social, our co-authors, clinical collaborators, and the patients who made this study possible - and to Ovo Labs for advancing this work.
#IVF #womenshealth
Thanks to @debojitsaha.bsky.social, our co-authors, clinical collaborators, and the patients who made this study possible - and to Ovo Labs for advancing this work.
#IVF #womenshealth
January 22, 2026 at 12:06 PM
🚀 Our research on human egg quality and #fertility is making headlines worldwide! 🌍
Thanks to @debojitsaha.bsky.social, our co-authors, clinical collaborators, and the patients who made this study possible - and to Ovo Labs for advancing this work.
#IVF #womenshealth
Thanks to @debojitsaha.bsky.social, our co-authors, clinical collaborators, and the patients who made this study possible - and to Ovo Labs for advancing this work.
#IVF #womenshealth
Our findings identify centromeric cohesion protection as a modifiable determinant of egg quality.
This is, to our knowledge, the first molecular intervention shown to improve chromosome cohesion in human eggs.
(9/10)
This is, to our knowledge, the first molecular intervention shown to improve chromosome cohesion in human eggs.
(9/10)
January 12, 2026 at 11:23 AM
Our findings identify centromeric cohesion protection as a modifiable determinant of egg quality.
This is, to our knowledge, the first molecular intervention shown to improve chromosome cohesion in human eggs.
(9/10)
This is, to our knowledge, the first molecular intervention shown to improve chromosome cohesion in human eggs.
(9/10)
Remarkably, SGO1 supplementation in human eggs significantly reduces premature chromatid separation and the number of single chromatids per egg.
This effect is consistent across donors. (8/10)
This effect is consistent across donors. (8/10)
January 12, 2026 at 11:23 AM
Remarkably, SGO1 supplementation in human eggs significantly reduces premature chromatid separation and the number of single chromatids per egg.
This effect is consistent across donors. (8/10)
This effect is consistent across donors. (8/10)
Human eggs show the same pattern.
Eggs from women ≥35 years have significantly reduced SGO1 and increased PSSC compared to younger donors.
Can this be rescued by supplementing SGO1? (7/10)
Eggs from women ≥35 years have significantly reduced SGO1 and increased PSSC compared to younger donors.
Can this be rescued by supplementing SGO1? (7/10)
January 12, 2026 at 11:23 AM
Human eggs show the same pattern.
Eggs from women ≥35 years have significantly reduced SGO1 and increased PSSC compared to younger donors.
Can this be rescued by supplementing SGO1? (7/10)
Eggs from women ≥35 years have significantly reduced SGO1 and increased PSSC compared to younger donors.
Can this be rescued by supplementing SGO1? (7/10)
Crucially, restoring SGO1 levels in aged mouse eggs rescues centromeric cohesion and reduces chromosome errors to youthful levels. But what about human oocytes, do they also lose SGO1 with age? (6/10)
January 12, 2026 at 11:23 AM
Crucially, restoring SGO1 levels in aged mouse eggs rescues centromeric cohesion and reduces chromosome errors to youthful levels. But what about human oocytes, do they also lose SGO1 with age? (6/10)
But how do cohesins and their protective factors change with age?
In aged mouse oocytes, we observe a decline in pericentromeric transcription, SGO1, PP2A, and centromeric cohesion.
This mirrors the dramatic rise in PSSC with age. (5/10)
In aged mouse oocytes, we observe a decline in pericentromeric transcription, SGO1, PP2A, and centromeric cohesion.
This mirrors the dramatic rise in PSSC with age. (5/10)
January 12, 2026 at 11:23 AM
But how do cohesins and their protective factors change with age?
In aged mouse oocytes, we observe a decline in pericentromeric transcription, SGO1, PP2A, and centromeric cohesion.
This mirrors the dramatic rise in PSSC with age. (5/10)
In aged mouse oocytes, we observe a decline in pericentromeric transcription, SGO1, PP2A, and centromeric cohesion.
This mirrors the dramatic rise in PSSC with age. (5/10)
We find that ongoing transcription at pericentromeres is essential to maintain SGO1 (and PP2A) on meiotic chromosomes.
Blocking transcription reduces SGO1 on chromosomes and triggers cohesion loss. (4/10)
Blocking transcription reduces SGO1 on chromosomes and triggers cohesion loss. (4/10)
January 12, 2026 at 11:23 AM
We find that ongoing transcription at pericentromeres is essential to maintain SGO1 (and PP2A) on meiotic chromosomes.
Blocking transcription reduces SGO1 on chromosomes and triggers cohesion loss. (4/10)
Blocking transcription reduces SGO1 on chromosomes and triggers cohesion loss. (4/10)
We identify Shugoshin 1 (SGO1) as a critical protector of centromeric cohesion in mammalian eggs.
In mouse oocytes, depletion of SGO1 with siRNAs causes cohesion failure (PSSC) and alignment defects. But how is SGO1 maintained at meiotic centromeres? (3/10)
In mouse oocytes, depletion of SGO1 with siRNAs causes cohesion failure (PSSC) and alignment defects. But how is SGO1 maintained at meiotic centromeres? (3/10)
January 12, 2026 at 11:23 AM
We identify Shugoshin 1 (SGO1) as a critical protector of centromeric cohesion in mammalian eggs.
In mouse oocytes, depletion of SGO1 with siRNAs causes cohesion failure (PSSC) and alignment defects. But how is SGO1 maintained at meiotic centromeres? (3/10)
In mouse oocytes, depletion of SGO1 with siRNAs causes cohesion failure (PSSC) and alignment defects. But how is SGO1 maintained at meiotic centromeres? (3/10)
Sister chromatids must stay tightly connected until fertilization.
When cohesion fails, chromatids separate prematurely — a defect called PSSC (premature separation of sister chromatids) — leading to mis-segregation and aneuploidy. (2/10)
When cohesion fails, chromatids separate prematurely — a defect called PSSC (premature separation of sister chromatids) — leading to mis-segregation and aneuploidy. (2/10)
January 12, 2026 at 11:23 AM
Sister chromatids must stay tightly connected until fertilization.
When cohesion fails, chromatids separate prematurely — a defect called PSSC (premature separation of sister chromatids) — leading to mis-segregation and aneuploidy. (2/10)
When cohesion fails, chromatids separate prematurely — a defect called PSSC (premature separation of sister chromatids) — leading to mis-segregation and aneuploidy. (2/10)
Human eggs must segregate their chromosomes with exquisite precision — yet errors rise with maternal age, causing miscarriage & infertility.
Our new article on @biorxivpreprint.bsky.social shows why chromosome cohesion fails in aging eggs & how to improve it.
www.biorxiv.org/content/10.6... (1/10)
Our new article on @biorxivpreprint.bsky.social shows why chromosome cohesion fails in aging eggs & how to improve it.
www.biorxiv.org/content/10.6... (1/10)
January 12, 2026 at 11:23 AM
Human eggs must segregate their chromosomes with exquisite precision — yet errors rise with maternal age, causing miscarriage & infertility.
Our new article on @biorxivpreprint.bsky.social shows why chromosome cohesion fails in aging eggs & how to improve it.
www.biorxiv.org/content/10.6... (1/10)
Our new article on @biorxivpreprint.bsky.social shows why chromosome cohesion fails in aging eggs & how to improve it.
www.biorxiv.org/content/10.6... (1/10)
The Schuh lab wishes you & your families a #MerryChristmas and a wonderful start to a happy & successful #NewYear2026 🎄✨
This year’s department Christmas card features a microscope image by our PostDoc @kosti-sofroni.bsky.social showing a fetal ovary containing prophase oocytes.
This year’s department Christmas card features a microscope image by our PostDoc @kosti-sofroni.bsky.social showing a fetal ovary containing prophase oocytes.
December 23, 2025 at 7:34 AM
The Schuh lab wishes you & your families a #MerryChristmas and a wonderful start to a happy & successful #NewYear2026 🎄✨
This year’s department Christmas card features a microscope image by our PostDoc @kosti-sofroni.bsky.social showing a fetal ovary containing prophase oocytes.
This year’s department Christmas card features a microscope image by our PostDoc @kosti-sofroni.bsky.social showing a fetal ovary containing prophase oocytes.
We’re excited to have Qiuyan join the Schuh lab as a postdoctoral researcher 🎉
She earned her PhD in Biological Sciences, with a research focus on understanding early embryonic development. In her new role, she’ll explore germ cell development.
Welcome to the team, Qiuyan!
She earned her PhD in Biological Sciences, with a research focus on understanding early embryonic development. In her new role, she’ll explore germ cell development.
Welcome to the team, Qiuyan!
December 16, 2025 at 3:15 PM
We’re excited to have Qiuyan join the Schuh lab as a postdoctoral researcher 🎉
She earned her PhD in Biological Sciences, with a research focus on understanding early embryonic development. In her new role, she’ll explore germ cell development.
Welcome to the team, Qiuyan!
She earned her PhD in Biological Sciences, with a research focus on understanding early embryonic development. In her new role, she’ll explore germ cell development.
Welcome to the team, Qiuyan!
Last week, we enjoyed wonderful days on our #labretreat at Ringberg Castle by Lake Tegernsee, together with the Rink Lab and Lenart Lab from @mpi-nat.bsky.social. We explored science, hiked, did yoga, played games, and shared lots of laughter. A perfect setting to exchange ideas and connect. 🧠🧘♀️🎲
October 10, 2025 at 7:27 AM
Last week, we enjoyed wonderful days on our #labretreat at Ringberg Castle by Lake Tegernsee, together with the Rink Lab and Lenart Lab from @mpi-nat.bsky.social. We explored science, hiked, did yoga, played games, and shared lots of laughter. A perfect setting to exchange ideas and connect. 🧠🧘♀️🎲
Across species, diverse strategies have evolved to store proteins, from large filamentous assemblies to membrane bound compartments. These systems prevent premature degradation and ensure key proteins are available when needed after fertilization. (3/5)
October 8, 2025 at 12:50 PM
Across species, diverse strategies have evolved to store proteins, from large filamentous assemblies to membrane bound compartments. These systems prevent premature degradation and ensure key proteins are available when needed after fertilization. (3/5)
Feeling excited & grateful 🌟
Honored to receive the Falling Walls Science Breakthrough 2025 (Life Sciences) — for our team’s live ovulation imaging.
Thanks to Tabea Lilian Marx, Christopher Thomas & our lab!
www.mpinat.mpg.de/5118437/pr_2...
#FallingWalls #ScienceSummit25 #ScienceBreakthroughs
Honored to receive the Falling Walls Science Breakthrough 2025 (Life Sciences) — for our team’s live ovulation imaging.
Thanks to Tabea Lilian Marx, Christopher Thomas & our lab!
www.mpinat.mpg.de/5118437/pr_2...
#FallingWalls #ScienceSummit25 #ScienceBreakthroughs
September 17, 2025 at 7:26 AM
Feeling excited & grateful 🌟
Honored to receive the Falling Walls Science Breakthrough 2025 (Life Sciences) — for our team’s live ovulation imaging.
Thanks to Tabea Lilian Marx, Christopher Thomas & our lab!
www.mpinat.mpg.de/5118437/pr_2...
#FallingWalls #ScienceSummit25 #ScienceBreakthroughs
Honored to receive the Falling Walls Science Breakthrough 2025 (Life Sciences) — for our team’s live ovulation imaging.
Thanks to Tabea Lilian Marx, Christopher Thomas & our lab!
www.mpinat.mpg.de/5118437/pr_2...
#FallingWalls #ScienceSummit25 #ScienceBreakthroughs
Our fantastic technician Kevin marked his 30th birthday 🎉 and of course, the traditional German „fegen“ (sweeping) ritual was part of the celebration. Cheered on by colleagues, he handled it with humor and a great attitude.
Welcome to your thirties, Kevin! 🧹🎂🥳
Welcome to your thirties, Kevin! 🧹🎂🥳
August 13, 2025 at 1:13 PM
Our fantastic technician Kevin marked his 30th birthday 🎉 and of course, the traditional German „fegen“ (sweeping) ritual was part of the celebration. Cheered on by colleagues, he handled it with humor and a great attitude.
Welcome to your thirties, Kevin! 🧹🎂🥳
Welcome to your thirties, Kevin! 🧹🎂🥳
This week, Melina gave the Theodor Boveri Award Lecture at the University of Würzburg - the university’s highest honor in #lifesciences. This lecture recognizes outstanding scientists whose work continues Theodor Boveri’s pioneering legacy.
Congratulations to Melina for this well-deserved honor! 🎉
Congratulations to Melina for this well-deserved honor! 🎉
July 18, 2025 at 9:13 AM
This week, Melina gave the Theodor Boveri Award Lecture at the University of Würzburg - the university’s highest honor in #lifesciences. This lecture recognizes outstanding scientists whose work continues Theodor Boveri’s pioneering legacy.
Congratulations to Melina for this well-deserved honor! 🎉
Congratulations to Melina for this well-deserved honor! 🎉
Our PostDoc @debojitsaha.bsky.social recently attended a @cshlcourses.bsky.social & came back with new techniques and stunning images. This mouse E9.5 embryo, labeled with Raldh2 (red), Fgf8 (green), Msx1 (magenta), DAPI (blue) is just one example. #Fluorescence revealing the magic of development!✨
July 15, 2025 at 7:16 AM
Our PostDoc @debojitsaha.bsky.social recently attended a @cshlcourses.bsky.social & came back with new techniques and stunning images. This mouse E9.5 embryo, labeled with Raldh2 (red), Fgf8 (green), Msx1 (magenta), DAPI (blue) is just one example. #Fluorescence revealing the magic of development!✨
What an inspiring #NachtdesWissens @ndw-goe.bsky.social in Göttingen! Thanks to our amazing team, who made our research on oocytes 🥚 fun and accessible for everyone. Great to see so many #curiousminds exploring our science up close and joining in creative activities! 🖍️🧑🔬
June 24, 2025 at 10:12 AM
What an inspiring #NachtdesWissens @ndw-goe.bsky.social in Göttingen! Thanks to our amazing team, who made our research on oocytes 🥚 fun and accessible for everyone. Great to see so many #curiousminds exploring our science up close and joining in creative activities! 🖍️🧑🔬
It was great having Mariia @schuhlab for her lab rotation within the IMPRS Molecular Biology Master Program. She presented her project, supervised by @ninaschweizer.bsky.social, in our large seminar room.
Congratulations on sucessfully finishing - well done! 🎉
#researchtogether #posterpresentation
Congratulations on sucessfully finishing - well done! 🎉
#researchtogether #posterpresentation
May 28, 2025 at 6:44 AM
It was great having Mariia @schuhlab for her lab rotation within the IMPRS Molecular Biology Master Program. She presented her project, supervised by @ninaschweizer.bsky.social, in our large seminar room.
Congratulations on sucessfully finishing - well done! 🎉
#researchtogether #posterpresentation
Congratulations on sucessfully finishing - well done! 🎉
#researchtogether #posterpresentation
We had the pleasure of welcoming RTG2756 PhD students from @unigoettingen.bsky.social to our lab for a hands-on methods course. Great vibes, curious minds, and lots of good science – we truly enjoyed having you with us! 🧪🔬 #PhDLife #ScienceTogether
www.uni-goettingen.de/rtg2756
www.uni-goettingen.de/rtg2756
May 20, 2025 at 10:06 AM
We had the pleasure of welcoming RTG2756 PhD students from @unigoettingen.bsky.social to our lab for a hands-on methods course. Great vibes, curious minds, and lots of good science – we truly enjoyed having you with us! 🧪🔬 #PhDLife #ScienceTogether
www.uni-goettingen.de/rtg2756
www.uni-goettingen.de/rtg2756
New face in the lab! 😊
We're excited to welcome @palmrinmoy.bsky.social as a new postdoc in the Schuh Lab 🎉He completed his PhD in the Torres-Padilla lab @www.helmholtz-munich.de, studying early embryonic development. Now, he'll investigate long-lived proteins in oocytes. Great to have you here!
We're excited to welcome @palmrinmoy.bsky.social as a new postdoc in the Schuh Lab 🎉He completed his PhD in the Torres-Padilla lab @www.helmholtz-munich.de, studying early embryonic development. Now, he'll investigate long-lived proteins in oocytes. Great to have you here!
May 9, 2025 at 8:29 AM
New face in the lab! 😊
We're excited to welcome @palmrinmoy.bsky.social as a new postdoc in the Schuh Lab 🎉He completed his PhD in the Torres-Padilla lab @www.helmholtz-munich.de, studying early embryonic development. Now, he'll investigate long-lived proteins in oocytes. Great to have you here!
We're excited to welcome @palmrinmoy.bsky.social as a new postdoc in the Schuh Lab 🎉He completed his PhD in the Torres-Padilla lab @www.helmholtz-munich.de, studying early embryonic development. Now, he'll investigate long-lived proteins in oocytes. Great to have you here!
Looking back at #Zukunftstag2025, we’re still inspired by the curiosity & enthusiasm of the students! 🔬✨ From pipetting skills to microscopy & liquid nitrogen fun, it was an unforgettable day in the world of science. Thanks to all participants!🌟 #FutureScientists
April 17, 2025 at 6:07 AM
Looking back at #Zukunftstag2025, we’re still inspired by the curiosity & enthusiasm of the students! 🔬✨ From pipetting skills to microscopy & liquid nitrogen fun, it was an unforgettable day in the world of science. Thanks to all participants!🌟 #FutureScientists
Many congratulations to Jurgita on receiving the prestigious HFSP Postdoctoral Fellowship for her groundbreaking project on protein storage in mammalian #oocytes. Jurgita, we are so proud of you for this well-deserved recognition! Stay tuned to follow her exciting research journey! 🏆🌟
April 10, 2025 at 7:00 AM
Many congratulations to Jurgita on receiving the prestigious HFSP Postdoctoral Fellowship for her groundbreaking project on protein storage in mammalian #oocytes. Jurgita, we are so proud of you for this well-deserved recognition! Stay tuned to follow her exciting research journey! 🏆🌟