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Reposted by Shan Siddiqi

Ethan Solomon @esolomon.bsky.social · Apr 3

When we use TMS to treat depression, we think it alters neural activity in a deep brain structure known as the subgenual anterior cingulate (sgACC). But this is hard to test directly, until our preprint with @coreykeller.bsky.social, @neuro-engineer.bsky.social, Nick Trapp, and Aaron Boes (UIowa) 1/

DLPFC Stimulation Suppresses High-Frequency Neural Activity in the Human sgACC

Transcranial magnetic stimulation (TMS) to the dorsolateral prefrontal cortex (DLPFC) is hypothesized to relieve symptoms of depression by inhibiting activity in the subgenual anterior cingulate corte...

www.biorxiv.org

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Reposted by Shan Siddiqi

Frederic Schaper @fredschaper.bsky.social · Mar 24

Is generalized epilepsy a seizure of the whole brain or a specific brain network?

In our new paper out now in @naturecomms.bsky.social, we investigate this by combining brain abnormalities and DBS with the human connectome.

Paper: nature.com/articles/s41...

A 🧵 below:

A generalized epilepsy network derived from brain abnormalities and deep brain stimulation - Nature Communications

Ji et al. identify an idiopathic generalised epilepsy network that links heterogeneously distributed brain abnormalities to a common brain network and deep brain stimulation sites which reduce general...

nature.com

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Shan Siddiqi @shansiddiqi.bsky.social · Mar 23

Out now in Brain

A distinct pattern of brain damage intensifies political involvement, regardless of whether you're liberal, conservative, Democrat, or Republican.

With coauthors S.Balters,S. Cohen-Zimerman,G.Zamboni,J.Grafman

academic.oup.com/brain/advanc...

@braincircuits.bsky.social

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Reposted by Shan Siddiqi

Andreas Horn @andreashorn.org · Mar 14

Looking toward to our ANPA symposium on interventional neuropsychiatry - kicked off w a brilliant talk & overview on TMS by Nick Trapp.

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Shan Siddiqi @shansiddiqi.bsky.social · Mar 7

Just to clarify, training won't be a prerequisite to providing brain stimulation... just an optional pathway to learn advanced techniques

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Shan Siddiqi @shansiddiqi.bsky.social · Mar 2

If this hasn't been reported before, I call dibs on the eponym "Shan's postulate"

Shan Siddiqi @shansiddiqi.bsky.social · Mar 2

Am I missing something? Is this just a mathematical fact? Or does it need to be validated empirically? It seems like most psychiatric biomarker studies miss this point, as does the culture around "target engagement" in the experimental therapeutics pipeline.

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Shan Siddiqi @shansiddiqi.bsky.social · Mar 2

If I'm correct, and if the depression scale has test-retest reliability of z(r) = 0.8ish and fMRI biomarker has test-retest reliability of z(r) = 0.6ish, then no fMRI biomarker model can accurately explain variance in depression better than r = 0.5.

All biomarker studies should assess reliability.

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Shan Siddiqi @shansiddiqi.bsky.social · Mar 2

I think the theoretical limit of explainable variance in a model should be less than the product of the test-retest reliabilities of the input variables. If the explained variance in a study exceeds that value (as it often does in the psychiatric literature), the model must be overfit.

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Shan Siddiqi @shansiddiqi.bsky.social · Feb 22

Out now in Brain Stimulation

Towards accredited training in brain stimulation: proceedings from the Brain Stimulation Subspecialty Summits (BraSSS)

with co-host Nolan Williams and 23 other awesome co-authors including some from @braincircuits.bsky.social

www.brainstimjrnl.com/article/S193...

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Reposted by Shan Siddiqi

Andreas Horn @andreashorn.org · Feb 17

Finally … this also means I am recruiting – big time!

Please email me in case you know somebody that might be interested (PhD/Postdoc positions). Please RT for reach! 🙏🙏

a yellow sign that says we 're hiring

ALT: a yellow sign that says we 're hiring

media.tenor.com

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Shan Siddiqi @shansiddiqi.bsky.social · Feb 16

My cat has developed a penchant for ⁦‪Kraepelin‬⁩. Last couple of days she just sits next to this old book (first edition English translation) and tries to read it.

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Reposted by Shan Siddiqi

Andrew Pines @andrewpines.bsky.social · Feb 12

jamanetwork.com/journals/jam...
Thread below👇

Mapping Lesions That Cause Psychosis

This case-control study analyzes published cases of lesion-induced psychosisTo assess whether lesions that cause secondary psychosis have functional connections to a common brain circuit

jamanetwork.com

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Reposted by Shan Siddiqi

Michael Fox @foxmdphd.bsky.social · Feb 13

Can damage to a specific brain circuit cause psychosis? New paper out today by @andrewpines.bsky.social @shansiddiqi.bsky.social says Yes! Hub of the circuit is in the hippocampus - great alignment with NMDA encephalitis. @braincircuits.bsky.social

Andrew Pines @andrewpines.bsky.social · Feb 12

What brain regions are involved in causing psychotic symptoms?

Take a moment away from the existential dread about the future of science, and join me in this summary of some incredibly cool stuff that could help patients!
1/n🧵

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Reposted by Shan Siddiqi

Andreas Horn @andreashorn.org · Feb 12

Do lesions that cause psychosis fall into a common brain network?

Exciting new work by @andrewpines.bsky.social, @shansiddiqi.bsky.social and colleagues – tweetorial below by the first author, paper here:
jamanetwork.com/journals/jam...

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Reposted by Shan Siddiqi

Andrew Pines @andrewpines.bsky.social · Feb 12

What brain regions are involved in causing psychotic symptoms?

Take a moment away from the existential dread about the future of science, and join me in this summary of some incredibly cool stuff that could help patients!
1/n🧵

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Shan Siddiqi @shansiddiqi.bsky.social · Feb 8

When the Nazis took power, I've of their most effective actions was to destroy the universities.

Carl T. Bergstrom @carlbergstrom.com · Feb 8

1. Today the NIH director issued a new directive slashing overhead rates to 15%.

I want to provide some context on what that means and why it matters.

grants.nih.gov/grants/guide...

NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates

NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD

grants.nih.gov

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Shan Siddiqi @shansiddiqi.bsky.social · Jan 27

Pleasure is all mine!

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Reposted by Shan Siddiqi

Phil Corlett @philcorlett.bsky.social · Jan 27

Super cool to finally meet @shansiddiqi.bsky.social this morning and hear about his lesion network mapping data for schizophrenia - and their consilience with our computational work in primates and paranoia!

#MDThalamus

Phil Corlett @philcorlett.bsky.social · Jan 27

Early start (7:30am symposium) in Grand Ballroom C, for WinterBrain

❄️🧠

I’ll be talking about translational approaches to paranoia, and consilience across rodents, primates, and humans

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Shan Siddiqi @shansiddiqi.bsky.social · Jan 25

That’s more like it

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Shan Siddiqi @shansiddiqi.bsky.social · Jan 24

I get it, bsky is great, but I find it harder to get motivated when there’s no vitriol to fight.
I need a troll.

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Shan Siddiqi @shansiddiqi.bsky.social · Jan 21

Anybody have experience with a successful R33 application?
There's no budget limit, so I'm trying to figure out what kind of budget might be perceived as excessive.

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Shan Siddiqi @shansiddiqi.bsky.social · Jan 12

ECT, TMS, and ketamine outperform other options for treatment resistant depression.

Should we be offering these options to patients earlier in the course of illness?

www.nature.com/articles/s41...

Relative effectiveness of antidepressant treatments in treatment-resistant depression: a systematic review and network meta-analysis of randomized controlled trials - Neuropsychopharmacology

Neuropsychopharmacology - Relative effectiveness of antidepressant treatments in treatment-resistant depression: a systematic review and network meta-analysis of randomized controlled trials

www.nature.com

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Reposted by Shan Siddiqi

David L Perez MD, MMSc @davidlewisperez.bsky.social · Jan 8

We are launching a new Harvard Medical School Continuing Medical Education Course

Brain Medicine: Integrating the Clinical Neurosciences
Live Virtual Course w On Demand Viewing for 30 days
February 7th, 2025

Registration Details Below (Join Us!):
cmecatalog.hms.harvard.edu/brain-medici...

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Reposted by Shan Siddiqi

Andreas Horn @andreashorn.org · Jan 8

🚨Interested in Dystonia?🚨
@braincircuits.bsky.social

GPi DBS for dystonia is effective.

More recently, STN DBS has been investigated, as an alternative.

In what enfolded like a stunning thriller to me, Konstantin Butenko tells a tale of two networks…

www.pnas.org/doi/10.1073/...

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