Sharan Malagobadan
@sharanm.bsky.social
RNA biology enthusiast | postdoc @ NCI/NIH
Reposted by Sharan Malagobadan
New online: DICER1 hotspot mutation induces 3p microRNA gain of function via Argonaute strand switch
DICER1 hotspot mutation induces 3p microRNA gain of function via Argonaute strand switch
Nature Structural & Molecular Biology, Published online: 04 November 2025; doi:10.1038/s41594-025-01671-wMalagobadan et al. show that a DICER1 hotspot mutation, previously thought to cause partial loss of function, also leads to unexpected gain of function by activating normally silent 3p passenger microRNAs, revealing a strand-switch mechanism in tumorigenesis.
go.nature.com
November 4, 2025 at 11:15 AM
New online: DICER1 hotspot mutation induces 3p microRNA gain of function via Argonaute strand switch