7/ The algorithm is simple:
Avoid SSRI monotherapy
Use SNRI/NRI/bupropion
Add anti-inflammatory augmentation
Fix metabolic + sleep issues
Treat the biology. Depression gets better.
That’s inflammatory depression in 7 tweets
#mentalhealth #psychiatry #depression #depressiontreatment #inflammation

6/ Lifestyle isn’t fluff — it’s upstream medicine:
Exercise ↓ CRP
Mediterranean diet ↓ IL-6
CBT-I ↓ inflammation
Treat sleep apnea, obesity, chronic pain.

5/ Cytokine targets matter:
Infliximab only helped people with high CRP.
Lurasidone works better when inflammation is elevated.

4/ Anti-inflammatory augmentation is the real power move:
Minocycline
Celecoxib
EPA (≥2 g/day)
NAC
Probiotics
All show bigger effects in inflamed depression.

3/ Nortriptyline beats escitalopram when CRP is up.
This is one of the cleanest biomarker-stratified findings in psychiatry.

2/ What does work?
Drugs that hit NE + DA, not pure serotonin.
Think: SNRIs, NRIs, bupropion.

1/ SSRIs often don’t work well in high inflammation.
GENDEP + multiple biomarker RCTs → flat or weaker response.

We don’t just need coping skills we need a cultural reboot.
Anxiety is information.
Listen to it.
#ShrinksInSneakers #Anxiety #Psychiatry #MentalHealth #mentalhealthawareness #anxietytips #anxietydisorder #psychiatrist #doctor #medical

The result? A generation living in fight-or-flight.
Anxiety isn’t a flaw it’s a feature of a world that overloads our biology

Then throw in social comparison and digital isolation we’re hyperconnected but lonelier than ever