New preprint from the lab!
A frontal motor circuit for economic decisions and actions:
www.biorxiv.org/content/10.6...

We use a novel task in mice, cortex-wide imaging and optogenetics, NPX recording and modelling to reveal a circuit mechanism that transforms abstract decisions to spatial actions.

I am thrilled to share our latest work led by @zurisullivan.bsky.social in collaboration with @moffittlab.bsky.social ! We find that the brain encodes distinct, pathogen-specific sickness states across behavior, physiology, neural activity, and gene expression 1/6

www.biorxiv.org/content/10.6...

1/ Why does RL struggle with social dilemmas? How can we ensure that AI learns to cooperate rather than compete?

Introducing our new framework: MUPI (Embedded Universal Predictive Intelligence) which provides a theoretical basis for new cooperative solutions in RL.

Preprint🧵👇

(Paper link below.)

John J. Vastola, Samuel J. Gershman, Kanaka Rajan: A Variational Manifold Embedding Framework for Nonlinear Dimensionality Reduction https://arxiv.org/abs/2511.22128 https://arxiv.org/pdf/2511.22128 https://arxiv.org/html/2511.22128

Thank you for the great summary, @thetransmitter.bsky.social, and the shout-outs from scientists we admire. There is so much we don’t know about how sex hormones modulate behavior and we’ll keep exploring!

So excited to see our latest paper out today in @natcomms.nature.com! Studies led by the amazing @margestelzner.bsky.social www.nature.com/articles/s41.... VTA GABA neurons have a unique role in economic decision making - they integrate reward seeking motivation and the current cost of seeking

1. New preprint resolving a conundrum in systems neuroscience with an AI scientist, and humans Reilly Tilbury, Dabin Kwon, @haydari.bsky.social, @jacobmratliff.bsky.social, @bio-emergent.bsky.social, @carandinilab.net, @kevinjmiller.bsky.social, @neurokim.bsky.social
www.biorxiv.org/content/10.1...