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Reposted by Sophie Adler

Stéphanie Baulac @sbaulac.bsky.social · May 15

📢 Paper out! Focal Cortical Dysplasia-linked epilepsy is more complex than expected - somatic mTOR-activating mutations affect multiple cell lineages, yet only a fraction become cytomegalic. Dysmorphic neurons show mitochondrial dysfunction. #Epilepsy #BrainMosaicism #Neurodevelopment

Nature Neuroscience @natneuro.nature.com · Apr 30

Single-cell genotyping and transcriptomic analysis reveals cell-type specific and non-autonomous effects of mTOR pathway mutations in mosaic focal cortical dysplasia type II (FCDII) 🧠🧪

www.nature.com/articles/s41...

Single-cell genotyping and transcriptomic profiling of mosaic focal cortical dysplasia - Nature Neuroscience

In this work, the authors performed a single-cell genotyping and transcriptomics analysis, revealing cell-type-specific and nonautonomous effects of mTOR pathway mutations in mosaic focal cortical dys...

www.nature.com

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Reposted by Sophie Adler

Konrad Wagstyl @konradwagstyl.bsky.social · Apr 17

Great to see MELD Graph being put to use by the team at Great Ormond Street @greatormondst.bsky.social
Find out more here : jamanetwork.com/journals/jam...
To give MELD a try: meld-graph.readthedocs.io/en/latest/in...
@mathrip.bsky.social @sophieadlerwagstyl.bsky.social

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Sophie Adler @sophieadlerwagstyl.bsky.social · Mar 15

#AI to find subtle #epilepsy lesions - check out @konradwagstyl.bsky.social explaining MELD Graph in the video! www.yahoo.com/news/ai-dete...

AI can detect minute brain abnormalities to treat epilepsy

STORY: :: King's College London/UCLThis MRI scan of a human brain shows in red an area that could be a potential lesion, and a possible cause of epilepsy.And a new artificial intelligence tool develop...

www.yahoo.com

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Reposted by Sophie Adler

UCL News @uclnews.bsky.social · Mar 6

A simple genomics blood test could improve treatment and care for childhood epilepsy, but more investment is needed to make access fair and securely join up the data, finds a new study involving researchers at @uclpophealthsci.bsky.social and @greatormondst.bsky.social www.ucl.ac.uk/news/2025/ma...

Genomics to revolutionise treatment of childhood rare diseases

A simple genomics blood test could improve treatment and care for childhood epilepsy, but more investment is needed to make access fair and securely join up the data, finds a new study involving resea...

www.ucl.ac.uk

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Sophie Adler @sophieadlerwagstyl.bsky.social · Feb 25

Really exciting to have our new AI tool, MELD Graph, featured on BBC News - Epilepsy AI tool detects brain lesions doctors miss
www.bbc.com/news/article...

Epilepsy AI tool detects brain lesions doctors miss

One in five epilepsy patients has uncontrolled seizures due to brain abnormalities too subtle for doctors to spot.

www.bbc.com

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Sophie Adler @sophieadlerwagstyl.bsky.social · Feb 25

Amazing work by @mathrip.bsky.social and the whole team creating MELD Graph - an AI tool to detect FCDs

Download it and test out this research tool on your patient's MRI scans!

Mathilde Ripart @mathrip.bsky.social · Feb 25

Very pleased to officially introduce MELD Graph, a novel AI tool for the detection of subtle focal cortical dysplasia (FCD) lesions in epilepsy patients.

Check out our paper published in JAMA Neurology yesterday! 😀https://jamanetwork.com/journals/jamaneurology/fullarticle/2830410

Detection of Epileptogenic Focal Cortical Dysplasia Using Graph Neural Networks

This study evaluates the efficacy and interpretability of graph neural networks in automatically detecting focal cortical dysplasia lesions on magnetic resonance imaging scans.

jamanetwork.com

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Reposted by Sophie Adler

UCL News @uclnews.bsky.social · Feb 24

A team of researchers including Prof Helen Cross & Drs @mathrip.bsky.social & @sophieadlerwagstyl.bsky.social @uclpophealthsci.bsky.social has developed an AI tool that can detect 64% of brain abnormalities associated with epilepsy that were missed by human radiologists www.ucl.ac.uk/news/2025/fe...

AI to diagnose invisible brain abnormalities in children with epilepsy

A team of researchers from UCL and King’s College London has developed an AI-powered tool that can detect 64% of brain abnormalities associated with epilepsy, that were missed by human radiologists.

www.ucl.ac.uk

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Sophie Adler @sophieadlerwagstyl.bsky.social · Jan 17

Invigorating and inspiring start to #epilepsyresearch in 2025 @youngepilepsy research retreat spanning across imaging, diagnostics, management, wellbeing, comobidities and outcomes.

Reposted by Sophie Adler

Ana Brandusescu @anabrandusescu.bsky.social · Dec 18

globe based on World Bank official boundaries showcasing

Datasets by country of origin

Over 90% of the datasets that the researchers analyzed came from Europe and North America, and less than 4% come from Africa.

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Reposted by Sophie Adler

Chris Carroll, MD @chriscarrollmd.com · Dec 9

Most babies who got very sick from RSV the last few winters were previously healthy. jamanetwork.com/journals/jam...

Infants Admitted to US Intensive Care Units for RSV Infection During the 2022 Seasonal Peak

This cross-sectional study evaluates the characteristics of infants admitted to US intensive care units for respiratory syncytial virus (RSV) infection during the 2022 seasonal peak.

jamanetwork.com

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Sophie Adler @sophieadlerwagstyl.bsky.social · Dec 10

Yesterday @konradwagstyl.bsky.social went "under the hood" - explaining the features the #AI model uses and how each added piece of info increases our confidence in where a lesion is #AES2024

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Sophie Adler @sophieadlerwagstyl.bsky.social · Dec 10

Dr Mathilde Ripart showcasing early work using #AI for multipathology detection in focal epilepsies #AES2024

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Sophie Adler @sophieadlerwagstyl.bsky.social · Dec 7

Interested in joining the MELD Project or trying out the tools for FCD or HS detection? Come chat to us #aes2024 after the presidential symposium or at the posters! @konradwagstyl.bsky.social

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Sophie Adler @sophieadlerwagstyl.bsky.social · Dec 6

Interested in imaging of epilepsy?? Join our session tomorrow on Imaging: past, passing and to come. Excited to be sharing our recent #MELDProjecg work @amepilepsysoc.bsky.social

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Reposted by Sophie Adler

Zeke Gleichgerrcht, MD, PhD @egleich.bsky.social · Dec 2

Thrilled to meet up with great friends and colleagues at #AES2024 in LA this week + good excuse to engage more w/ BlueSky! Don’t miss our session on Advanced Neuroimaging for Personalized Epilepsy Surgery—designed for clinicians & researchers, including patient testimony
@amepilepsysoc.bsky.social

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Sophie Adler @sophieadlerwagstyl.bsky.social · Dec 5

📢 JOB AD 📢
Interested in gene expression, neurodevelopment, rare genetic disorders, machine learning .. apply to join our growing team!

Konrad Wagstyl @konradwagstyl.bsky.social · Nov 25

🚨📣Job ad 📣🚨
Interested in a post-doc creating machine learning tools for neurodevelopmental disorders? Come work with us at the IMAGINE lab!
www.kcl.ac.uk/jobs/100005-...
imaginelab.github.io

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Sophie Adler @sophieadlerwagstyl.bsky.social · Dec 5

Excited to join #bsky in time for #AES2024 - here for all things epilepsy / neuroimaging / children 👋

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