Søren Hough
@sorenhough.bsky.social
Cancer biologist/science+film journalist. Freelance at RogerEbert.com. Editor at The Commoner. EIC at Movie Fail. PhD (Biochemistry). Editing w/ pen + #CRISPR 🍞🏴 https://sorenhough.com/
Reposted by Søren Hough
Awesome collaboration with @SPJacksonGroup, @drjhujh.bsky.social, Chris Carney and Soren Hough, understanding how inherited mutations in the MEAE E3 ubiquitin ligase causes disease by compromising HR-dependent replication fork protection/restart. link.springer.com/article/10.1...
Loss of CTLH component MAEA impairs DNA repair and replication and leads to developmental delay - EMBO Molecular Medicine
Ubiquitin E3 ligases play crucial roles in the DNA damage response (DDR) by modulating the turnover, localization, activation, and interactions of DDR and DNA replication proteins. We performed a CRIS...
link.springer.com
December 19, 2025 at 5:17 PM
Awesome collaboration with @SPJacksonGroup, @drjhujh.bsky.social, Chris Carney and Soren Hough, understanding how inherited mutations in the MEAE E3 ubiquitin ligase causes disease by compromising HR-dependent replication fork protection/restart. link.springer.com/article/10.1...
Reposted by Søren Hough
Great to see this team effort out, in which we find a new player in genome stability and a neurodevelopmental disease caused by its loss. Fantastic collaboration with @drjhujh.bsky.social and @profstewartlab.bsky.social alongside @sorenhough.bsky.social and friends in @spjacksongroup.bsky.social.
Loss of CTLH component MAEA impairs #DNArepair and replication and leads to #DevelopmentalDelay
By S. Hough, S. Jackson & colleagues @cam.ac.uk @cruk-ci.bsky.social
🗞️ doi.org/10.1038/s443...
By S. Hough, S. Jackson & colleagues @cam.ac.uk @cruk-ci.bsky.social
🗞️ doi.org/10.1038/s443...
December 19, 2025 at 10:11 PM
Great to see this team effort out, in which we find a new player in genome stability and a neurodevelopmental disease caused by its loss. Fantastic collaboration with @drjhujh.bsky.social and @profstewartlab.bsky.social alongside @sorenhough.bsky.social and friends in @spjacksongroup.bsky.social.
Reposted by Søren Hough
Loss of CTLH component MAEA impairs #DNArepair and replication and leads to #DevelopmentalDelay
By S. Hough, S. Jackson & colleagues @cam.ac.uk @cruk-ci.bsky.social
🗞️ doi.org/10.1038/s443...
By S. Hough, S. Jackson & colleagues @cam.ac.uk @cruk-ci.bsky.social
🗞️ doi.org/10.1038/s443...
December 19, 2025 at 9:09 PM
Loss of CTLH component MAEA impairs #DNArepair and replication and leads to #DevelopmentalDelay
By S. Hough, S. Jackson & colleagues @cam.ac.uk @cruk-ci.bsky.social
🗞️ doi.org/10.1038/s443...
By S. Hough, S. Jackson & colleagues @cam.ac.uk @cruk-ci.bsky.social
🗞️ doi.org/10.1038/s443...
Reposted by Søren Hough
So proud to have co-authored this paper with @sorenhough.bsky.social identifying mutations in MAEA, an E3 ligase, as underlying a novel disease resulting from defective HR-dependent replication fork protection/restart 🥳
Grateful to everyone that contributed, incl. the patients & their families!
Grateful to everyone that contributed, incl. the patients & their families!
Awesome collaboration with @SPJacksonGroup, @drjhujh.bsky.social, Chris Carney and Soren Hough, understanding how inherited mutations in the MEAE E3 ubiquitin ligase causes disease by compromising HR-dependent replication fork protection/restart. link.springer.com/article/10.1...
Loss of CTLH component MAEA impairs DNA repair and replication and leads to developmental delay - EMBO Molecular Medicine
Ubiquitin E3 ligases play crucial roles in the DNA damage response (DDR) by modulating the turnover, localization, activation, and interactions of DDR and DNA replication proteins. We performed a CRIS...
link.springer.com
December 19, 2025 at 5:28 PM
So proud to have co-authored this paper with @sorenhough.bsky.social identifying mutations in MAEA, an E3 ligase, as underlying a novel disease resulting from defective HR-dependent replication fork protection/restart 🥳
Grateful to everyone that contributed, incl. the patients & their families!
Grateful to everyone that contributed, incl. the patients & their families!
It's not every day you get to name a developmental condition! Introducing the world to DIADEM: Developmental delay and Intellectual disability Associated with DEfects in MAEA 👑
It was an honor to work with such an amazing team of scientists, clinicians, and patients/families on this paper.
It was an honor to work with such an amazing team of scientists, clinicians, and patients/families on this paper.
So proud to have co-authored this paper with @sorenhough.bsky.social identifying mutations in MAEA, an E3 ligase, as underlying a novel disease resulting from defective HR-dependent replication fork protection/restart 🥳
Grateful to everyone that contributed, incl. the patients & their families!
Grateful to everyone that contributed, incl. the patients & their families!
Awesome collaboration with @SPJacksonGroup, @drjhujh.bsky.social, Chris Carney and Soren Hough, understanding how inherited mutations in the MEAE E3 ubiquitin ligase causes disease by compromising HR-dependent replication fork protection/restart. link.springer.com/article/10.1...
December 19, 2025 at 9:38 PM
It's not every day you get to name a developmental condition! Introducing the world to DIADEM: Developmental delay and Intellectual disability Associated with DEfects in MAEA 👑
It was an honor to work with such an amazing team of scientists, clinicians, and patients/families on this paper.
It was an honor to work with such an amazing team of scientists, clinicians, and patients/families on this paper.
Reposted by Søren Hough
This is the best piece I’ve read so far on why the Guinea-Bissau RCT, in which a proven life-saving vaccine will be deliberately WITHHELD, is unethical
“When benefit is established, withholding an intervention is no longer neutral experimentation it becomes premeditated harm”
“When benefit is established, withholding an intervention is no longer neutral experimentation it becomes premeditated harm”
The planned hepatitis B birth-dose trial in Guinea-Bissau raises serious ethical concerns. Withholding a proven, life-saving vaccine from newborns to answer speculative questions is an absence of equipoise with real downstream harms for trust in vaccines.
bktitanji.substack.com/p/how-unethi...
bktitanji.substack.com/p/how-unethi...
How Unethical Research Seeds Medical Mistrust
The absence of equipoise can turn research into harm
bktitanji.substack.com
December 18, 2025 at 11:06 PM
This is the best piece I’ve read so far on why the Guinea-Bissau RCT, in which a proven life-saving vaccine will be deliberately WITHHELD, is unethical
“When benefit is established, withholding an intervention is no longer neutral experimentation it becomes premeditated harm”
“When benefit is established, withholding an intervention is no longer neutral experimentation it becomes premeditated harm”
Reposted by Søren Hough
Preclinical research shows ASOs could delay retinal degeneration in juvenile Batten’s disease.
BioXconomy spoke to study author Michelle Hastings about what her team’s findings could mean for the future treatment of Batten disease.
Read my full article below:
www.bioxconomy.com/modalities/a...
BioXconomy spoke to study author Michelle Hastings about what her team’s findings could mean for the future treatment of Batten disease.
Read my full article below:
www.bioxconomy.com/modalities/a...
ASOs could delay blindness in children with Batten's
Preclinical research shows ASOs could delay retinal degeneration in juvenile Batten’s disease.
www.bioxconomy.com
November 27, 2025 at 3:02 PM
Preclinical research shows ASOs could delay retinal degeneration in juvenile Batten’s disease.
BioXconomy spoke to study author Michelle Hastings about what her team’s findings could mean for the future treatment of Batten disease.
Read my full article below:
www.bioxconomy.com/modalities/a...
BioXconomy spoke to study author Michelle Hastings about what her team’s findings could mean for the future treatment of Batten disease.
Read my full article below:
www.bioxconomy.com/modalities/a...
Reposted by Søren Hough
Net migration to Britain has fallen by almost 80% from its 2023 peak, according to data released on Thursday.
The British Public Thinks Immigration Is Up. It’s Actually Down, Sharply.
Net migration to Britain has fallen by almost 80 percent from its 2023 peak, according to data released on Thursday.
nyti.ms
November 27, 2025 at 4:30 PM
Net migration to Britain has fallen by almost 80% from its 2023 peak, according to data released on Thursday.
Reposted by Søren Hough
Instagram has become a pipeline for extremist content. Influencers like Hayden McDougall and Dylan Shane are blasting out extremist content, Nazi symbols, and hate-branded merchandise to massive audiences. The platform’s refusal to intervene is turning fringe neo-Nazism into mainstream culture.
Instagram’s Antisemitism Economy
Instagram has become a marketplace for antisemitism. Influencers like Hayden McDougall, Dylan Shane, Jake Shields, and Myron Gaines are using the platform’s massive reach to glorify Hitler, deny the H...
globalextremism.org
November 27, 2025 at 4:57 PM
Instagram has become a pipeline for extremist content. Influencers like Hayden McDougall and Dylan Shane are blasting out extremist content, Nazi symbols, and hate-branded merchandise to massive audiences. The platform’s refusal to intervene is turning fringe neo-Nazism into mainstream culture.
There's a lot of conspiracy theorizing about bad actors in drug development out there — that there's some magic pill for cancer that we aren't being told about, for example.
It's rightfully dismissed as nonsense.
It's rightfully dismissed as nonsense.
November 1, 2025 at 12:21 PM
There's a lot of conspiracy theorizing about bad actors in drug development out there — that there's some magic pill for cancer that we aren't being told about, for example.
It's rightfully dismissed as nonsense.
It's rightfully dismissed as nonsense.
Reposted by Søren Hough
wikipedia's data shows that AI is siphoning traffic away from the site, which is a danger to its sustainability. ironically Wikipedia is more important than ever to users who want reliable information instead of slop, and to AI companies that need it for training data www.404media.co/wikipedia-sa...
Wikipedia Says AI Is Causing a Dangerous Decline in Human Visitors
“With fewer visits to Wikipedia, fewer volunteers may grow and enrich the content, and fewer individual donors may support this work.”
www.404media.co
October 17, 2025 at 1:15 AM
wikipedia's data shows that AI is siphoning traffic away from the site, which is a danger to its sustainability. ironically Wikipedia is more important than ever to users who want reliable information instead of slop, and to AI companies that need it for training data www.404media.co/wikipedia-sa...
Reposted by Søren Hough
Not the main thing really but the way Mark Zuckerberg pretends to just randomly think of a recipe (while all the ingredients are already on the table) right at the start is hilarious
bsky.app/profile/shac...
bsky.app/profile/shac...
September 18, 2025 at 11:26 AM
Not the main thing really but the way Mark Zuckerberg pretends to just randomly think of a recipe (while all the ingredients are already on the table) right at the start is hilarious
bsky.app/profile/shac...
bsky.app/profile/shac...
In a world first, a progressive multiple sclerosis patient at Nebraska Medicine was treated with an allogeneic CAR T therapy.
“I'm walking. My gait is so much better,” she said. “I feel better.”
You can read my full article over at BioXconomy: www.bioxconomy.com/modalities/m...
#CellTherapy
“I'm walking. My gait is so much better,” she said. “I feel better.”
You can read my full article over at BioXconomy: www.bioxconomy.com/modalities/m...
#CellTherapy
Multiple sclerosis patient treated with CAR T therapy
A landmark allogeneic cell therapy treatment could alter the futures of MS patients facing progressive neurodegeneration.
www.bioxconomy.com
September 5, 2025 at 5:32 PM
In a world first, a progressive multiple sclerosis patient at Nebraska Medicine was treated with an allogeneic CAR T therapy.
“I'm walking. My gait is so much better,” she said. “I feel better.”
You can read my full article over at BioXconomy: www.bioxconomy.com/modalities/m...
#CellTherapy
“I'm walking. My gait is so much better,” she said. “I feel better.”
You can read my full article over at BioXconomy: www.bioxconomy.com/modalities/m...
#CellTherapy
Reposted by Søren Hough
A good first post might be the link to this new "about us" interview in BioXconomy. www.bioxconomy.com/innovation/n...
Nonprofit looks to bring tomorrow’s science into today’s classrooms
BioXconomy sat down with Natalie Kuldell, founder and executive director of nonprofit organization BioBuilder Education Foundation, to discuss its function, its importance, and its effect in the life ...
www.bioxconomy.com
November 20, 2024 at 3:51 PM
A good first post might be the link to this new "about us" interview in BioXconomy. www.bioxconomy.com/innovation/n...
Reposted by Søren Hough
Signal or noise? > Making peptides a ‘staple’ of cancer treatment Making
peptides a ‘staple’ of cancer treatment with Peter ‘t Hart -
BioXconomy >> Comment below! #strategy #competitiveintelligence #marketing #pharmaceutical #healthcare #competitivemarketing #pharma #biotech
peptides a ‘staple’ of cancer treatment with Peter ‘t Hart -
BioXconomy >> Comment below! #strategy #competitiveintelligence #marketing #pharmaceutical #healthcare #competitivemarketing #pharma #biotech
Making peptides a ‘staple’ of cancer treatment Making
peptides a ‘staple’ of cancer treatment with Peter ‘t Hart -
BioXconomy
Making peptides a ‘staple’ of cancer treatment Making peptides a ‘staple’ of cancer treatment with Peter ‘t Hart BioXconomy
dlvr.it
August 30, 2025 at 2:30 AM
Signal or noise? > Making peptides a ‘staple’ of cancer treatment Making
peptides a ‘staple’ of cancer treatment with Peter ‘t Hart -
BioXconomy >> Comment below! #strategy #competitiveintelligence #marketing #pharmaceutical #healthcare #competitivemarketing #pharma #biotech
peptides a ‘staple’ of cancer treatment with Peter ‘t Hart -
BioXconomy >> Comment below! #strategy #competitiveintelligence #marketing #pharmaceutical #healthcare #competitivemarketing #pharma #biotech
Reposted by Søren Hough
Reposted by Søren Hough
I spoke with journalist Søren Hough at BioXconomy about RFK Jr & Jay Bhattacharya's pathetic, anti-scientific, fact-free reasons they gave for canceling mRNA vaccine R&D.
"Perhaps we should not have been surprised," I said, "given their anti-vaccine activism.”
www.bioxconomy.com/modalities/e...
"Perhaps we should not have been surprised," I said, "given their anti-vaccine activism.”
www.bioxconomy.com/modalities/e...
Experts reject HHS disparagement of mRNA technology
World-leading vaccine and public health experts say NIH director Jay Bhattacharya’s recent op-ed is “infuriating” and “anti-scientific.”
www.bioxconomy.com
August 28, 2025 at 3:27 PM
I spoke with journalist Søren Hough at BioXconomy about RFK Jr & Jay Bhattacharya's pathetic, anti-scientific, fact-free reasons they gave for canceling mRNA vaccine R&D.
"Perhaps we should not have been surprised," I said, "given their anti-vaccine activism.”
www.bioxconomy.com/modalities/e...
"Perhaps we should not have been surprised," I said, "given their anti-vaccine activism.”
www.bioxconomy.com/modalities/e...
Now that we're on a shiny new website over at BioXconomy, I figured I'd reshare some of my favorite articles I've written.
First up, my editorial about how CRISPR was both essential to my PhD research and also has the potential to fuel a new eugenics movement:
www.bioxconomy.com/modalities/f...
First up, my editorial about how CRISPR was both essential to my PhD research and also has the potential to fuel a new eugenics movement:
www.bioxconomy.com/modalities/f...
Fixing what isn’t broken: CRISPR’s potential to erase biocultural diversity Søren Hough, PhD Søren Hough, PhD
CRISPR has accelerated healthcare research, but risks being pulled into dark history plagued by racism and ableism.
www.bioxconomy.com
August 20, 2025 at 11:29 AM
Now that we're on a shiny new website over at BioXconomy, I figured I'd reshare some of my favorite articles I've written.
First up, my editorial about how CRISPR was both essential to my PhD research and also has the potential to fuel a new eugenics movement:
www.bioxconomy.com/modalities/f...
First up, my editorial about how CRISPR was both essential to my PhD research and also has the potential to fuel a new eugenics movement:
www.bioxconomy.com/modalities/f...
Reposted by Søren Hough
I'm a historian of anticolonialism and anarchism in the 20C. My first book, 'Anarchy or Chaos', is a biography of India's foremost anarchist activist M.P.T. Acharya, and I am currently writing a book on the Indian revolutionary movement in Europe, 1905-1918. www.hurstpublishers.com/book/anarchy...
Anarchy or Chaos | Hurst Publishers
The first biography of an extraordinary political thinker at the heart of India's struggles against colonial and domestic oppression.
www.hurstpublishers.com
November 10, 2024 at 7:43 AM
I'm a historian of anticolonialism and anarchism in the 20C. My first book, 'Anarchy or Chaos', is a biography of India's foremost anarchist activist M.P.T. Acharya, and I am currently writing a book on the Indian revolutionary movement in Europe, 1905-1918. www.hurstpublishers.com/book/anarchy...
Reposted by Søren Hough
Sur Marie Godsmith, il y a un projet de valorisation à mettre en avant en ce 1er Mai (à l'intersection entre science et anarchisme : mariegoldsmith.uk
Sinon, sa fiche du Maitron est bien fournie : maitron.fr/goldsmith-ma...
Sinon, sa fiche du Maitron est bien fournie : maitron.fr/goldsmith-ma...
The Marie Goldsmith Project
Reviving the life and thought of the anarchist and scientist, Marie Goldsmith.
mariegoldsmith.uk
May 1, 2025 at 11:55 AM
Sur Marie Godsmith, il y a un projet de valorisation à mettre en avant en ce 1er Mai (à l'intersection entre science et anarchisme : mariegoldsmith.uk
Sinon, sa fiche du Maitron est bien fournie : maitron.fr/goldsmith-ma...
Sinon, sa fiche du Maitron est bien fournie : maitron.fr/goldsmith-ma...
Reposted by Søren Hough
I'm so glad to hear that the Marie Goldsmith Project has received a British Academy/Leverhulme Trust Small Research Grant finish the translation and annotation of "Revolutionary Syndicalism and Anarchism: Struggle with Capital and Power" (1920). mariegoldsmith.uk
The Marie Goldsmith Project
Marie Goldsmith in her laboratory (c. 1910) From Anarchistes en exil : correspondance inédite de Pierre Kropotkine à Marie Goldsmith, 1897-1917 by Michael Confino This website is dedicated to compilin...
mariegoldsmith.uk
September 24, 2024 at 9:00 AM
I'm so glad to hear that the Marie Goldsmith Project has received a British Academy/Leverhulme Trust Small Research Grant finish the translation and annotation of "Revolutionary Syndicalism and Anarchism: Struggle with Capital and Power" (1920). mariegoldsmith.uk
Reposted by Søren Hough
The whole leaded gasoline tale is the stuff of supervillains. For four decades a small group of people knowingly poisoned the world for the sake of profit, despite knowing that safer alternatives to their product are available. In a just world Robert Kehoe has the same reputation as Josef Mengele.
December 31, 2024 at 7:07 PM
The whole leaded gasoline tale is the stuff of supervillains. For four decades a small group of people knowingly poisoned the world for the sake of profit, despite knowing that safer alternatives to their product are available. In a just world Robert Kehoe has the same reputation as Josef Mengele.
Reposted by Søren Hough
The most stunning thing I learned through the series was the role of Robert Kehoe in preserving the leaded gas industry. People knew in the 1920s it was dangerous. But Kehoe had total control over the science of lead for 40 years, preventing possible regulation.
en.wikipedia.org/wiki/Robert_...
en.wikipedia.org/wiki/Robert_...
Robert A. Kehoe - Wikipedia
en.wikipedia.org
December 31, 2024 at 6:50 PM
The most stunning thing I learned through the series was the role of Robert Kehoe in preserving the leaded gas industry. People knew in the 1920s it was dangerous. But Kehoe had total control over the science of lead for 40 years, preventing possible regulation.
en.wikipedia.org/wiki/Robert_...
en.wikipedia.org/wiki/Robert_...
Reposted by Søren Hough
The project I most enjoyed working on in 2024 was my 3-episode series on industrial chemist Thomas Midgley Jr. for QAA's "Trickle Down."
It's my favorite kind of tale from history: one that's never fully told in popular accounts and has lessons for the 21st century.
www.patreon.com/posts/trickl...
It's my favorite kind of tale from history: one that's never fully told in popular accounts and has lessons for the 21st century.
www.patreon.com/posts/trickl...
Trickle Down Episode 15: Earth's Most Destructive Organism Part 1 | QAA
Get more from QAA on Patreon
www.patreon.com
December 31, 2024 at 6:43 PM
The project I most enjoyed working on in 2024 was my 3-episode series on industrial chemist Thomas Midgley Jr. for QAA's "Trickle Down."
It's my favorite kind of tale from history: one that's never fully told in popular accounts and has lessons for the 21st century.
www.patreon.com/posts/trickl...
It's my favorite kind of tale from history: one that's never fully told in popular accounts and has lessons for the 21st century.
www.patreon.com/posts/trickl...
I wouldn't have been able to complete my PhD research without CRISPR. I think it's one of the most incredible tools in the history of the field of biology. But with great power, as they say, comes great responsibility.
lifesciences.connectmeinforma.com/community/ti...
lifesciences.connectmeinforma.com/community/ti...
December 23, 2024 at 5:26 PM
I wouldn't have been able to complete my PhD research without CRISPR. I think it's one of the most incredible tools in the history of the field of biology. But with great power, as they say, comes great responsibility.
lifesciences.connectmeinforma.com/community/ti...
lifesciences.connectmeinforma.com/community/ti...