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Reposted by Stephanie Wankowicz

Mary Anne Franks @maryannefranks.bsky.social · 1d

"Academic freedom policies came from faculties, not the government. Governments are the enemies of academic freedom, not their protectors." Brilliant piece by @sivav.bsky.social about the Trump administrations' latest effort to censor universities newrepublic.com/article/2013...

Why This Essay Could Cause the University of Virginia to Shut Down

How Linda McMahon’s latest “compact” would do deep and permanent harm to American higher education

newrepublic.com

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Reposted by Stephanie Wankowicz

Diffuse Project @diffuseproject.bsky.social · 2d

The Diffuse Project is looking for an amazing Project Manager to help us achieve our goal of unlocking protein dynamics! Are you a scientist who naturally loves organization, coordination, problem solving and working with a diverse team of scientists & engineers?

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Reposted by Stephanie Wankowicz

Stephanie Wankowicz @stephanieaw.bsky.social · 11d

TTPD #7 with @fraserlab.com.

We chatted about the recent meetings, news, preprint engagement notifications, and the point of rotations.
wankowiczlab.com/2025/09/27/T...
Spotify: open.spotify.com/episode/0JCB...

The Tortured Proteins Department, Episode 7

This is the official web page for the Stephanie Wankowicz Lab at Vanderbilt University.

wankowiczlab.com

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Stephanie Wankowicz @stephanieaw.bsky.social · 11d

Runner wedding bliss!

Stephanie Wankowicz @stephanieaw.bsky.social · 11d

Preprint #3: High-resolution ab initio reconstruction enables cryo-EM structure determination of small particles www.biorxiv.org/content/10.1... @olibclarke.bsky.social

High-resolution ab initio reconstruction enables cryo-EM structure determination of small particles

Despite recent advances in data acquisition and algorithmic development, applying single particle cryogenic electron microscopy (cryoEM) to small proteins (<50kDa) remains challenging, even when high ...

www.biorxiv.org

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Stephanie Wankowicz @stephanieaw.bsky.social · 11d

Preprint #2: Improved cryo-EM reconstruction of sub-50 kDa complexes using 2D template matching www.biorxiv.org/content/10.1... @grigoriefflab.bsky.social @kekexinz.bsky.social

Improved cryo-EM reconstruction of sub-50 kDa complexes using 2D template matching

Visualizing the structures of small proteins and complexes has been a longstanding challenge in single-particle cryo-EM. Some of these targets have been successfully resolved by binding to antibody fr...

www.biorxiv.org

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Stephanie Wankowicz @stephanieaw.bsky.social · 11d

Preprint #1: Generative design of novel bacteriophages with genome language models
www.biorxiv.org/content/10.1... @brianhie.bsky.social @samuelhking.bsky.social @claudiadriscoll.bsky.social

www.biorxiv.org

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Stephanie Wankowicz @stephanieaw.bsky.social · 11d

TTPD #7 with @fraserlab.com.

We chatted about the recent meetings, news, preprint engagement notifications, and the point of rotations.
wankowiczlab.com/2025/09/27/T...
Spotify: open.spotify.com/episode/0JCB...

The Tortured Proteins Department, Episode 7

This is the official web page for the Stephanie Wankowicz Lab at Vanderbilt University.

wankowiczlab.com

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Stephanie Wankowicz @stephanieaw.bsky.social · 11d

This is scary

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Reposted by Stephanie Wankowicz

Vanderbilt Center for Structural Biology @vanderbiltcsb.bsky.social · 12d

With a new collaboration called diffUSE, the @stephanieaw.bsky.social lab is helping to advance our understanding of protein motion, leading to a new paradigm in dynamic structural biology.
@vubasicsciences.bsky.social
medschool.vanderbilt.edu/basic-scienc...

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Reposted by Stephanie Wankowicz

Drug Monkey @drugmonkey.bsky.social · 13d

This may be the most important paper ever published about NIH funded research.

www.science.org/doi/10.1126/...

What if NIH had been 40% smaller?

Replaying history with less NIH funding shows widespread impacts on drug-linked research

www.science.org

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Reposted by Stephanie Wankowicz

Nozomi Ando @nozomi-ando.bsky.social · 14d

Fall beamtime begins! Here is Sarah @andolab.bsky.social ! 😎⚡️

@diffuseproject.bsky.social

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Stephanie Wankowicz @stephanieaw.bsky.social · 15d

A joy we can all agree we need in our lives right now.

The New York Times @nytimes.com · 15d

It is Fat Bear Week in Alaska. The popular competition lets anyone vote on which of the animals is most prepared for winter. nyti.ms/3IBbucx

A very large brown bear walking in a field of grass.

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Reposted by Stephanie Wankowicz

Kexin Zhang @kekexinz.bsky.social · 21d

🚀 Check out our new preprint on extending the scope of single-particle cryo-EM with 2D template matching!
Improved cryo-EM reconstruction of sub-50 kDa complexes using 2D template matching is now available on bioRxiv!
www.biorxiv.org/content/10.1...

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Stephanie Wankowicz @stephanieaw.bsky.social · 22d

Peak millennial humor.

The New York Times @nytimes.com · 22d

LimeWire, which became popular in the 2000s, has been revealed as the buyer that paid $245,000 for the rights to the Fyre Festival. It’s unclear what exactly it plans to do with the embattled brand.

LimeWire, the Former File-Sharing Service, Is Buying Fyre Festival Brand

The streaming service, which became popular in the 2000s, paid $245,000 for the festival naming rights. It’s unclear what exactly it plans to do with the embattled brand.

nyti.ms

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Stephanie Wankowicz @stephanieaw.bsky.social · 27d

As always, feedback is always appreciated!

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Stephanie Wankowicz @stephanieaw.bsky.social · 27d

Rules include: define biological selection criteria, set up QC, beware PDB biases, mind sample size/stats/uncertainty, choose proper controls, compare metrics consistently, link to other databases, and visualize everything!

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Stephanie Wankowicz @stephanieaw.bsky.social · 27d

I originally put this guide together for my lab, but expanded it into a “10 Rules” article on how to use structural bioinformatics effectively.

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Stephanie Wankowicz @stephanieaw.bsky.social · 27d

Structural bioinformatics is incredibly powerful on its own or when paired with theory or experiment. One of the PDB's superpowers isn’t from one structure, but comparing many to uncover folds, binding sites, and subtle conformational shifts. chemrxiv.org/engage/chemr...

10 Rules for a Structural Bioinformatic Analysis

The Protein Data Bank (PDB) is one of the richest open‑source repositories in biology, housing over 277,000 macromolecular structural models alongside much of the experimental data that underpins thes...

chemrxiv.org

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Stephanie Wankowicz @stephanieaw.bsky.social · 28d

Why do people think they will get away with lying on their resume?

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Reposted by Stephanie Wankowicz

Elizabeth Jacobs, PhD @elizabethjacobs.bsky.social · Sep 4

These statements about corruption in science are egregious lies. Kennedy is a tsunami of anti-science propaganda.

This isn’t just a moral injury to scientists, it is downright dangerous.

It is devastating that the U.S. Senate is permitting this.

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Stephanie Wankowicz @stephanieaw.bsky.social · Sep 4

@aliceyting.bsky.social

Stephanie Wankowicz @stephanieaw.bsky.social · Sep 4

@paulschanda.bsky.social

Stephanie Wankowicz @stephanieaw.bsky.social · Sep 3

Thank you! I hope we don't disappoint too badly with other episodes (but we have improved with every recording!).

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Reposted by Stephanie Wankowicz

Jim Van Deventer @vandeventerjim.bsky.social · Sep 3

Today, I'm grateful for the podcast The Tortured Proteins Department. Excellent back-and-forth between @fraserlab.com and @stephanieaw.bsky.social. Disclaimer: I've only listened to episode 6; I hope it's not an outlier! 🤪

podcasts.apple.com/us/podcast/t...

The Tortured Proteins Department

Life Sciences Podcast · Updated Monthly · A deep dive into scientific discovery and the process of doing science, hosted by Stephanie Wankowicz and James Fraser.

podcasts.apple.com

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