Shashi Thutupalli
@stpalli.bsky.social
1K followers 380 following 17 posts
Scientist, Associate Professor at the Simons Centre for the Study of Living Machines, NCBS Bangalore and ICTS, Bangalore. Broadly interested in the origins and organisation of living systems. Bangalore — Toronto — Göttingen — Princeton — Bangalore
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stpalli.bsky.social
We're looking for creative engineers/tinkerers/tool builders that want to engage with cutting-edge research questions in our lab at the @ncbsbangalore.bsky.social

Please help me share the word!
stpalli.bsky.social
We're looking for creative engineers/tinkerers/tool builders that want to engage with cutting-edge research questions in our lab at the @ncbsbangalore.bsky.social

Please help me share the word!
stpalli.bsky.social
The Skysynth feature of from the Vera Rubin Observatory (@vrubinobs.bsky.social) is absolutely magical. Explore cosmic sounds. To get an idea, turn on your speakers for the movie below -- it's amazing!

rubinobservatory.org/news/rubin-f...
stpalli.bsky.social
They are fanning themselves, clearly :)
stpalli.bsky.social
As always, Will is a master storyteller! Here’s a great thread about our recent paper.
wcratcliff.bsky.social
1/27 We have a new paper out! Turns out that snowflake yeast have been hiding a secret from us - they've evolved a (very!) crude circulatory system. Not with blood vessels or a heart, but through spontaneous fluid flows powered by their metabolism. 🧪🔬

www.science.org/doi/full/10....
stpalli.bsky.social
We find that simple metabolically-driven physical mechanisms can be co-opted to generate large flows, upending the long held view that flagella or complex fluid transport structures are required for the evolution of large size in multicellular organisms.

www.science.org/doi/10.1126/...
Metabolically driven flows enable exponential growth in macroscopic multicellular yeast
Metabolically generated flow is an emergent mechanism that alleviates diffusion limits in macroscopic multicellular yeast.
www.science.org
stpalli.bsky.social
We have a new paper out on an issue that has been discussed for more than a century -- how can fundamental biophysical constraints on nutrient transport be overcome to solve one of the most significant challenges associated with the evolution of multicellularity?

www.science.org/doi/10.1126/...
stpalli.bsky.social
We’re celebrating the newest graduate from my lab — Dr. Charuhansini Tvishamayi!

Those of you in Bangalore, free next Sunday and interested, please come, it will be a pleasure!

Poster courtesy: members of the lab.
stpalli.bsky.social
Such a cool finding, this! So great to see this since my group and I have discussed for years about how measuring the "energetic content" of cells using so called "bomb calorimetry" can be very misleading -- all gradient information is lost that way and clearly it is significant!
nadlerlab.bsky.social
Why are biological membranes asymmetric, with different lipids in the two bilayer leaflets? Discovered in the 70s, lipid asymmetry is linked to many cellular processes, but why the cell needs it is largely unclear. @pavelbarahtjan.bsky.social addresses this question: www.biorxiv.org/content/10.1...
stpalli.bsky.social
Very interesting work! Looking forward to digging into the details.
Reposted by Shashi Thutupalli
thattai.bsky.social
I first visited KITP-UCSB as a grad student in 2003, and immediately fell in love with it. Here is the story of how my notebook from a 2010 KITP program I co-ran, on evolutionary cell biology, became the source of research questions that keep me busy to this day! www.kitp.ucsb.edu/sites/defaul...
Extract from KITP's Fall 2024 Newsletter
stpalli.bsky.social
Longer lengths and larger volume fractions are both coming up. Hopefully should have some news soon.
stpalli.bsky.social
Yes! We were intrigued by that too. Have not commented on it in this current paper but have some ideas on why that happens.

In the meantime, here is a video of the chemical field which causes the S to be a metastable configuration.
stpalli.bsky.social
Yes, here's the S-C transition!
stpalli.bsky.social
Before I start posting about newer results on this platform, here is a video from our most recent paper -- www.nature.com/articles/s41...
stpalli.bsky.social
Perhaps it's simply the oily and watery parts of the beeswax separating out.
stpalli.bsky.social
Classic phase separation.