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SUNRiSE network

@sunrise-network.bsky.social

100 followers 140 following 9 posts

The “Stem Cells and Solid Tumors” network SUNRiSE (Solid Tumor Cancer Stem Cell Network) aims to promote fundamental and applied research in the field of cancer stem cells of solid tumors.

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SUNRiSE network @sunrise-network.bsky.social · May 19

Don't forget our next webinar tomorrow at 4 pm (CET)!
We are very happy to welcome Pr Robert Weinberg 😊
umontpellier-fr.zoom.us/j/98333758557

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SUNRiSE network @sunrise-network.bsky.social · Jul 18

Amazing job! Well done guys! Funny how conventional therapies enrich for hybrid GBM cells🤩

Giorgio Seano @giorgioseano.bsky.social · Jul 17

🧠 Why does glioblastoma always outsmart treatment? In our #Neuro-Oncology paper, we identified proneural-mesenchymal hybrid glioblastoma cells that are resistant to therapy and dependent on nuclear import. doi.org/10.1093/neuo...
Short walkthrough below. Let’s dive in! 🧵 (1/9)
#GBM, #BrainTumor

Background: Despite extensive research efforts, glioblastoma (GBM) remains a deadly disease with poor prognosis. Although previous studies have identified various cell states within GBM tumors, the molecular mechanism underlying adaptive GBM cell plasticity induced by conventional therapy remains unclear.
Methods: We used fluorescent reporters for proneural (PN) and mesenchymal (MES) subtypes to monitor GBM cell plasticity in real-time across multiple patient-derived cell lines. This approach revealed cells that concurrently expressed both proneural and mesenchymal markers. To investigate this unique hybrid population, we implemented a comprehensive methodological approach encompassing bulk and single-cell RNA sequencing, single-cell ChIP sequencing, nuclear proteomics, high-resolution imaging, orthotopic mouse models, clinical dataset analysis, and pharmacological and genetic techniques. This multifaceted strategy allowed us to gain functional and molecular insights into this distinct cellular population.
Results: We showed that these hybrid cells are increased by conventional therapies, and are resistant to these therapies. At the molecular level, hybrid cells display significant alterations in chromatin structure and nuclear protein composition, elevated transcriptional activity, Myc activation, and improved transport between the nucleus and cytoplasm. Genetic and pharmaceutical inhibition of the nuclear import/export shuttling machinery, increased in hybrid cells, effectively suppressed adaptive GBM cell plasticity and hybrid identity, thereby enhancing the sensitivity of GBM cells to therapies.
Conclusion: Our results indicate that GBM hybrid cells play a crucial role in chemoradiation resistance. The nuclear transport machinery presents a potential therapeutic target for hybrid cells, offering a way to counteract the typical resistance to treatment observed in GBM.

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SUNRiSE network @sunrise-network.bsky.social · Jun 12

Very nice talk and amazing work 🤩

SUNRiSE network @sunrise-network.bsky.social · May 20

It was amazing! Merci Robert!

SUNRiSE network @sunrise-network.bsky.social · May 20

It's starting 🤓! Join us now!

Reposted by SUNRiSE network

John De Vos @jdevos.bsky.social · May 14

💥 The FSSCR annual meeting is set to take place in Lyon from November 17th to 19th, 2025. Prepare for an incredible lineup of speakers and an outstanding program! 👇🏻
buff.ly/KA0nL6e
ABSTRACT submission now available.

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SUNRiSE network @sunrise-network.bsky.social · May 20

It's today!🚨 Looking forward to listen Pr Robert A.Weinberg 🤩

SUNRiSE network @sunrise-network.bsky.social · May 19

Don't forget our next webinar tomorrow at 4 pm (CET)!
We are very happy to welcome Pr Robert Weinberg 😊
umontpellier-fr.zoom.us/j/98333758557

1 2

SUNRiSE network @sunrise-network.bsky.social · May 19

Don't forget our next webinar tomorrow at 4 pm (CET)!
We are very happy to welcome Pr Robert Weinberg 😊
umontpellier-fr.zoom.us/j/98333758557

1 1

Reposted by SUNRiSE network

CNRS Biologie @cnrsbiologie.bsky.social · Feb 28

🐠✨ Comment le poisson-clown échappe-t-il aux toxines de son anémone protectrice ? Grâce à… son mucus ! 🧐

Un nouvel épisode passionnant du podcast Avec Sciences sur @franceculture.fr explore cette incroyable adaptation. 🌊🔬

🎧 À écouter ici 👉 buff.ly/3XoPQwj

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SUNRiSE network @sunrise-network.bsky.social · Feb 5

C'est aujourd'hui 🤩

SUNRiSE network @sunrise-network.bsky.social · Jan 2

Ne passez pas à côté de notre formation annuelle sur l'hétérogénéité et la plasticité tumorale !
#cancer #stemcell

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Reposted by SUNRiSE network

Eric Topol @erictopol.bsky.social · Feb 4

A very innovative approach to cancer: engineering fat cells to convert to beige fat to starve tumors, outcompeting 5 types of cancer in experimental models
www.nature.com/articles/s41... @naturebiotech.bsky.social y.social @nadavahituv.bsky.social tuv.bsky.social

Implantation of engineered adipocytes suppresses tumor progression in cancer models - Nature Biotechnology

Adipose manipulation transplantation can reduce tumor growth and proliferation in vitro and in mouse models.

www.nature.com

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Reposted by SUNRiSE network

WHO @who.int · Feb 4

Today is #WorldCancerDay

Did you know❓

Vaccination against #hepatitisB can help prevent liver cancer in children, while #HPV vaccination for young girls can reduce the risk of #CervicalCancer later in life.

Learn more 👉bit.ly/2NeFF8B

Vaccination against hepatitis B can help prevent liver cancer in children, against human papillomavirus (HPV) in young girls can help prevent cervical cancer later in life.

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Reposted by SUNRiSE network

Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · Feb 4

www.cell.com/iscience/ful...

Endothelial calcium firing mediates the extravasation of metastatic tumor cells

Cell biology; Functional aspects of cell biology; Cancer

www.cell.com

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Reposted by SUNRiSE network

brumbaugh-lab.bsky.social @brumbaugh-lab.bsky.social · Jan 10

Our new paper defining the role of H3K36 methylation in regulating cell fate and plasticity is available online: rdcu.be/d5AEc
Thanks to our entire team for their tireless work and to the editors at @naturecellbiology.bsky.social for the opportunity!

H3K36 methylation regulates cell plasticity and regeneration in the intestinal epithelium

Nature Cell Biology - Pashos et al. show that H3K36 methylation maintains intestinal epithelial fate commitment, whereas its suppression, which is also observed upon injury, induces a plastic state...

rdcu.be

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Reposted by SUNRiSE network

SUNRiSE network @sunrise-network.bsky.social · Jan 2

Plaquette d'information et programme détaillé : 4jc9j.r.a.d.sendibm1.com/mk/cl/f/sh/6...

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Reposted by SUNRiSE network

SUNRiSE network @sunrise-network.bsky.social · Jan 2

Ne passez pas à côté de notre formation annuelle sur l'hétérogénéité et la plasticité tumorale !
#cancer #stemcell

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SUNRiSE network @sunrise-network.bsky.social · Jan 2

Plaquette d'information et programme détaillé : 4jc9j.r.a.d.sendibm1.com/mk/cl/f/sh/6...

1 1

SUNRiSE network @sunrise-network.bsky.social · Jan 2

Ne passez pas à côté de notre formation annuelle sur l'hétérogénéité et la plasticité tumorale !
#cancer #stemcell

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