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Sussex Blood Cancer Research @sussexbcr.bsky.social · 1d

💰New funding update💰

Congratulations @rhysmorganlab.bsky.social in @biochembiomeduos.bsky.social for obtaining funding from @bloodcanceruk.bsky.social to target abnormal cell signalling mechanisms in AML.

This is now 1 of 6 active Blood Cancer UK grants in our growing network at Sussex. 👊 🔬🧬🥼🩸

Rhys Morgan @rhysmorganlab.bsky.social · 8d

Very grateful to have been awarded our first @bloodcanceruk.bsky.social research grant over the summer for our work targeting aberrant Wnt/β-catenin signalling in acute myeloid leukaemia (AML).

Our new project headed by Dr Wagstaff begins Oct 1st developing new ways to target oncogenic β-catenin 👊

Reposted by Sussex Blood Cancer Research

Rhys Morgan @rhysmorganlab.bsky.social · 8d

Very grateful to have been awarded our first @bloodcanceruk.bsky.social research grant over the summer for our work targeting aberrant Wnt/β-catenin signalling in acute myeloid leukaemia (AML).

Our new project headed by Dr Wagstaff begins Oct 1st developing new ways to target oncogenic β-catenin 👊

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Reposted by Sussex Blood Cancer Research

Tim Humphrey @humphreylab.bsky.social · 9d

Delighted to wave the flag for @gdsc-sussex.bsky.social
@sussexcancer.org
@sussexbcr.bsky.social
sussexcancerfund.co.uk together with Rhys Morgan at the Science Cafe, MacMillan Horizon centre today. Thanks to Rebecca Herbertson and Stephen Robinson for organizing.
@rhysmorganlab.bsky.social

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Sussex Blood Cancer Research @sussexbcr.bsky.social · 15d

Our Co-Directors Prof @chrispepper68.bsky.social and Dr @rhysmorganlab.bsky.social explain the mission and vision for the Sussex Blood Cancer Research network.

@sussexcancer.org @bsmsmedschool.bsky.social @biochembiomeduos.bsky.social

Brighton and Sussex Medical School @bsmsmedschool.bsky.social · 15d

💡 How are #BSMS researchers working to change the future of blood cancer?
Prof Chris Pepper and Dr Rhys Morgan share their journey, their goals and why this research matters.
▶Watch here: www.youtube.com/watch?v=0EwD...
@sussexbcr.bsky.social #MedicalResearch

Prof Chris Pepper and Dr Rhys Morgan - Sussex Blood Cancer Research

YouTube video by Brighton and Sussex Medical School

www.youtube.com

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Reposted by Sussex Blood Cancer Research

Brighton and Sussex Medical School @bsmsmedschool.bsky.social · 15d

💡 How are #BSMS researchers working to change the future of blood cancer?
Prof Chris Pepper and Dr Rhys Morgan share their journey, their goals and why this research matters.
▶Watch here: www.youtube.com/watch?v=0EwD...
@sussexbcr.bsky.social #MedicalResearch

Prof Chris Pepper and Dr Rhys Morgan - Sussex Blood Cancer Research

YouTube video by Brighton and Sussex Medical School

www.youtube.com

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Sussex Blood Cancer Research @sussexbcr.bsky.social · 29d

🗞️ New network publication!🗞️

Final year PhD student Aimilia Vareli in @bsmsmedschool.bsky.social of @mitchell.science lab publishes her doctoral studies in @springernature.com
#CellDeathDisease showing inhibition of NFkB signalling increases BH3 mimetic sensitivity in the lymphoma microenvironment.

Simon Mitchell @mitchell.science · Aug 18

New paper led by Aimilia Vareli out now.
nature.com/articles/s41...
The lymphoma microenvironment stops BH3-mimetics working.
In vitro/vivo/silico, we find inhibition of NFκB makes BH3-mimetics great again.🧵
@sussexbcr.bsky.social @bsmsmedschool.bsky.social @leukaemiauk.bsky.social @sussexcancer.org

Systems biology-enabled targeting of NF-κΒ and BCL2 overcomes microenvironment-mediated BH3-mimetic resistance in DLBCL - Cell Death & Disease

Cell Death & Disease - Systems biology-enabled targeting of NF-κΒ and BCL2 overcomes microenvironment-mediated BH3-mimetic resistance in DLBCL

nature.com

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Reposted by Sussex Blood Cancer Research

Simon Mitchell @mitchell.science · Aug 18

New paper led by Aimilia Vareli out now.
nature.com/articles/s41...
The lymphoma microenvironment stops BH3-mimetics working.
In vitro/vivo/silico, we find inhibition of NFκB makes BH3-mimetics great again.🧵
@sussexbcr.bsky.social @bsmsmedschool.bsky.social @leukaemiauk.bsky.social @sussexcancer.org

Systems biology-enabled targeting of NF-κΒ and BCL2 overcomes microenvironment-mediated BH3-mimetic resistance in DLBCL - Cell Death & Disease

Cell Death & Disease - Systems biology-enabled targeting of NF-κΒ and BCL2 overcomes microenvironment-mediated BH3-mimetic resistance in DLBCL

nature.com

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Sussex Blood Cancer Research @sussexbcr.bsky.social · 29d

Join Dr Jasmeen Oberoi's research group on a @bloodcanceruk.bsky.social funded project as a Research Technician in Protein Biochemistry for 6mo, investigating structure and function of fusion kinase complexes in leukaemia.

Great opportunity for a candidate looking to build research experience!

Jasmeen Oberoi @jasmeenoberoi.bsky.social · 29d

🧬🧪 A research technician position - Protein Biochemistry (6 months) is available in my lab @gdsc-sussex.bsky.social investigating structure and function of fusion kinase complexes in Leukaemia.

📅 Deadline: 29th September 2025.

🙏 Please share with anyone who might be interested.

Research Technician – Protein Biochemistry at University of Sussex

Explore an exciting academic career as a Research Technician – Protein Biochemistry. Don't miss out on other academic jobs. Click to apply and explore more opportunities.

www.jobs.ac.uk

Reposted by Sussex Blood Cancer Research

Jasmeen Oberoi @jasmeenoberoi.bsky.social · 29d

🧬🧪 A research technician position - Protein Biochemistry (6 months) is available in my lab @gdsc-sussex.bsky.social investigating structure and function of fusion kinase complexes in Leukaemia.

📅 Deadline: 29th September 2025.

🙏 Please share with anyone who might be interested.

Research Technician – Protein Biochemistry at University of Sussex

Explore an exciting academic career as a Research Technician – Protein Biochemistry. Don't miss out on other academic jobs. Click to apply and explore more opportunities.

www.jobs.ac.uk

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Reposted by Sussex Blood Cancer Research

Jasmeen Oberoi @jasmeenoberoi.bsky.social · Sep 4

Research is never a solo effort.
It takes teamwork. It takes belief. It takes collaboration across disciplines, institutions, and communities.
We know what it takes to beat blood cancer.
#BloodCancerAwarenessMonth
@bloodcanceruk.bsky.social @sussexbcr.bsky.social @sussexcancer.org 🩸

Blood cancer awareness month. Image from Blood Cancer UK campaign. "It takes Science and Stubbornness".

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Sussex Blood Cancer Research @sussexbcr.bsky.social · Aug 28

🗞️ New network publication! 📰

Final year PhD student Aimilia Vareli in @bsmsmedschool.bsky.social in the @mitchell.science lab publishes her doctoral studies in @springernature.com #CellDeathDisease showing inhibition of NFkB signalling increases sensitivity to BH3 mimetics for lymphoma treatment.

Simon Mitchell @mitchell.science · Aug 18

New paper led by Aimilia Vareli out now.
nature.com/articles/s41...
The lymphoma microenvironment stops BH3-mimetics working.
In vitro/vivo/silico, we find inhibition of NFκB makes BH3-mimetics great again.🧵
@sussexbcr.bsky.social @bsmsmedschool.bsky.social @leukaemiauk.bsky.social @sussexcancer.org

Systems biology-enabled targeting of NF-κΒ and BCL2 overcomes microenvironment-mediated BH3-mimetic resistance in DLBCL - Cell Death & Disease

Cell Death & Disease - Systems biology-enabled targeting of NF-κΒ and BCL2 overcomes microenvironment-mediated BH3-mimetic resistance in DLBCL

nature.com

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Reposted by Sussex Blood Cancer Research

Genome Damage and Stability Centre (GDSC) @gdsc-sussex.bsky.social · Jul 18

Great post-doctoral opportunity in the laboratory of Dr Jasmeen Oberoi — who has just joined us as a team leader in the GDSC.

Jasmeen Oberoi @jasmeenoberoi.bsky.social · Jul 17

📢 New Postdoc opportunity

🧬🧪🩸 Excited to share an MRC funded Research Fellow position is available in my lab @gdsc-sussex.bsky.social to investigate novel approaches to disrupt the function of fusion kinases and their regulation by the HSP90 molecular chaperone system in leukaemia.

Research Fellow in Cancer Research at University of Sussex

An academic position as a Research Fellow in Cancer Research is being advertised on jobs.ac.uk. Click now to find more details and explore additional academic job opportunities.

www.jobs.ac.uk

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Reposted by Sussex Blood Cancer Research

Jasmeen Oberoi @jasmeenoberoi.bsky.social · Jul 17

📢 New Postdoc opportunity

🧬🧪🩸 Excited to share an MRC funded Research Fellow position is available in my lab @gdsc-sussex.bsky.social to investigate novel approaches to disrupt the function of fusion kinases and their regulation by the HSP90 molecular chaperone system in leukaemia.

Research Fellow in Cancer Research at University of Sussex

An academic position as a Research Fellow in Cancer Research is being advertised on jobs.ac.uk. Click now to find more details and explore additional academic job opportunities.

www.jobs.ac.uk

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Sussex Blood Cancer Research @sussexbcr.bsky.social · Jul 17

Completed your PhD? Interested in leukaemia research? Want to join a new/exciting PI as they establish their group at @gdsc-sussex.bsky.social

Then this post doc with new MRC CDA Fellow & @bloodcanceruk.bsky.social funded Dr @jasmeenoberoi.bsky.social is 4 you 👇

jobs.sussex.ac.uk/job/fe31a03c...

Research Fellow in Cancer Research Ref: 41067 (Fixed Term) - Job page - University of Sussex Job Search

jobs.sussex.ac.uk

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Sussex Blood Cancer Research @sussexbcr.bsky.social · Jul 7

🗞️ New publication from the network 🗞️

Dr @ejayawant.bsky.social now working at the Pepper group in @bsmsmedschool.bsky.social review the state of play in computational modelling of B-cell lymphomas, led by @mitchell.science and now out at @biochemsoc.bsky.social Transactions.

Simon Mitchell @mitchell.science · Jul 4

New paper led by @ejayawant.bsky.social 🎉
We review:
- how computational biology is helping us understand lymphoma,
- how machine learning and cell simulations make sense of vast amounts of data,
- how models can personalise treatments to each person with lymphoma.
portlandpress.com/biochemsoctr...

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Reposted by Sussex Blood Cancer Research

Simon Mitchell @mitchell.science · Jul 4

New paper led by @ejayawant.bsky.social 🎉
We review:
- how computational biology is helping us understand lymphoma,
- how machine learning and cell simulations make sense of vast amounts of data,
- how models can personalise treatments to each person with lymphoma.
portlandpress.com/biochemsoctr...

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Reposted by Sussex Blood Cancer Research

Sussex Cancer Research Centre @sussexcancer.org · Jun 10

Artist’s blood cancer treatment inspires powerful new exhibition at University of Brighton, @bsmsmedschool.bsky.social

www.brighton.ac.uk/news/2025/ar...

Artist’s blood cancer treatment inspires powerful new exhibition at University of Brighton

A University of Brighton graduate has turned his own cancer journey into a striking art installation exploring illness and the duality of medical treatment.

www.brighton.ac.uk

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Reposted by Sussex Blood Cancer Research

Genome Damage and Stability Centre (GDSC) @gdsc-sussex.bsky.social · Jun 23

Prof. Evi Soutoglou describing what happens when DNA breaks, and when to cut, and when not to — on Brighton seafront, as part of Soapbox Science 2025 — a public outreach platform that promote women and non-binary scientists and the science that they carry out. ‪@soapboxscience.bsky.social‬

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Reposted by Sussex Blood Cancer Research

Genome Damage and Stability Centre (GDSC) @gdsc-sussex.bsky.social · Jun 24

Dr. Luke Yates, along with Prof. Zhang and Prof. Burgers, summarise our current mechanistic understanding of the DNA damage checkpoint; inc. structural studies of ATM and ATR and how these work together to prevent cancer.
doi.org/10.1146/annu...
@layates.bsky.social @crick.ac.uk @washu.bsky.social

DNA Damage and Replication Stress Checkpoints | Annual Reviews

DNA damage checkpoints are key regulatory signaling cascades that arrest cell cycle progression upon DNA damage or upon DNA replication stalling and allow time for repair or correction. Failure to eli...

doi.org

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Reposted by Sussex Blood Cancer Research

Rhys Morgan @rhysmorganlab.bsky.social · Jun 25

Following on from our recent paper showing novel post-transcriptional roles for B-catenin in leukaemia cells, a very well done to Drs Sevim & Park for writing a superb review in @natureportfolio.nature.com Oncogene summarising our current understanding of this field.

www.nature.com/articles/s41...

Post-transcriptional control of gene expression by β-catenin: expanding the non-canonical ARMoury - Oncogene

Oncogene - Post-transcriptional control of gene expression by β-catenin: expanding the non-canonical ARMoury

www.nature.com

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Reposted by Sussex Blood Cancer Research

Sussex Cancer Research Centre @sussexcancer.org · Jul 1

We are excited to announce a new round of funding available thanks to the @SxCancerFund
The 2025 SCF:SCRC Pump-Priming Awards scheme is now open!
Dealine: 4th August 2025
sussexcancer.org/news/new-scf...
@uniofbrighton.bsky.social
@bsmsmedschool.bsky.social

New SCF/SCRC pump-priming awards open for applications. — Sussex Cancer Research Centre

The Sussex Cancer Researh Centre are excited to announce a new round of funding available thanks to the incredible support of our partners: The Sussex Cancer Fund.

sussexcancer.org

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Reposted by Sussex Blood Cancer Research

Biochemistry & Biomedicine @ University of Sussex @biochembiomeduos.bsky.social · Jun 6

Congrats to Dr Mark Samuels from Giamas lab in Life Sci @sussex.ac.uk on publishing on his PhD research on LMTK3 regulation of EV biogenesis in breast cancer and its impact on the immune system in @springernature.com Mol Cancer. @sussexcancer.org

molecular-cancer.biomedcentral.com/articles/10....

LMTK3 regulation of EV biogenesis and cargo sorting promotes tumour growth by reducing monocyte infiltration and driving pro-tumourigenic macrophage polarisation in breast cancer - Molecular Cancer

Background Lemur Tail Kinase 3 (LMTK3) promotes cell proliferation, invasiveness and therapy resistance, and its expression correlates with poor survival in several different malignancies, including b...

molecular-cancer.biomedcentral.com

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Reposted by Sussex Blood Cancer Research

Ethan L Morgan @ethanlmorgan.bsky.social · Jun 6

A bit late to post but glad to see our review on novel oncogenic mechanisms of the HPV oncoproteins. Great work from undergraduate student Denise in my lab @biochemsoc.bsky.social @biochembiomeduos.bsky.social #HPV

portlandpress.com/biochemsoctr...

Advances in understanding the mechanisms of the human papillomavirus oncoproteins

High-risk human papillomaviruses (HPVs) are responsible for almost all cervical cancer cases and a growing number of oropharyngeal and anogenital cancers. The primary HPV oncoproteins, E6 and E7, act ...

portlandpress.com

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Sussex Blood Cancer Research @sussexbcr.bsky.social · Jun 6

🥼New PhD opportunity🔬

3.5year funded studentship (UK fees only) available with @rhysmorganlab.bsky.social and Dr David Palmer in the School of Life Sciences from Sept 2025 researching RUNX1 mutations in myeloid leukaemia.

Deadline for applications June 25th 23.45 on link below. 👇

Rhys Morgan @rhysmorganlab.bsky.social · Jun 6

Join me + Dr David Palmer, Haematology Clinician at UHS NHS @bsmsmedschool.bsky.social, for a 3.5yr School of Life Sci funded PhD (UK fees only) studying RUNX1 mutations in myeloid leukaemia here at @sussex.ac.uk @sussexbcr.bsky.social @sussexcancer.org

Details 👇

www.sussex.ac.uk/study/fees-f...

School of Life Sciences Studentship : University of Sussex

www.sussex.ac.uk

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Reposted by Sussex Blood Cancer Research

Rhys Morgan @rhysmorganlab.bsky.social · Jun 6

Join me + Dr David Palmer, Haematology Clinician at UHS NHS @bsmsmedschool.bsky.social, for a 3.5yr School of Life Sci funded PhD (UK fees only) studying RUNX1 mutations in myeloid leukaemia here at @sussex.ac.uk @sussexbcr.bsky.social @sussexcancer.org

Details 👇

www.sussex.ac.uk/study/fees-f...

School of Life Sciences Studentship : University of Sussex

www.sussex.ac.uk

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