Reposted by Tal Sharf
Slate status: not blank
Preconfigured neuronal firing sequences in human brain organoids www.nature.com/articles/s41... "...results suggest that temporal sequences do not arise in an experience-dependent manner, but are rather constrained by a preconfigured architecture established during neurodevelopment"
Preconfigured neuronal firing sequences in human brain organoids - Nature Neuroscience
Examining human brain organoids and ex vivo neonatal murine cortical slices demonstrates that structured neuronal sequences emerge independently of sensory input, highlighting the potential of brain o...
www.nature.com
November 25, 2025 at 8:12 AM
Slate status: not blank
I was told it would take about three years to get a new lab up and running. Nearly three years later, our work on preconfigured neuronal firing sequences in human brain organoids is finally out in Nature Neuroscience: www.nature.com/articles/s41...
Preconfigured neuronal firing sequences in human brain organoids - Nature Neuroscience
Examining human brain organoids and ex vivo neonatal murine cortical slices demonstrates that structured neuronal sequences emerge independently of sensory input, highlighting the potential of brain o...
www.nature.com
November 25, 2025 at 2:04 AM
I was told it would take about three years to get a new lab up and running. Nearly three years later, our work on preconfigured neuronal firing sequences in human brain organoids is finally out in Nature Neuroscience: www.nature.com/articles/s41...
"We can, should, and will use cerebral organoids to discover new medical treatments, study brain development, reduce the demand for animal testing, and even power computers and more energy-efficient AI."
www.vox.com/future-perfe...
www.vox.com/future-perfe...
The challenge of creating brains in a lab
Lab-grown brains don’t have to inspire horror.
www.vox.com
October 31, 2025 at 9:19 PM
"We can, should, and will use cerebral organoids to discover new medical treatments, study brain development, reduce the demand for animal testing, and even power computers and more energy-efficient AI."
www.vox.com/future-perfe...
www.vox.com/future-perfe...
Reposted by Tal Sharf
In an NSF-supported study, @talsharf.bsky.social and collaborators will investigate the capacity of human brain organoids to learn and adapt, with implications for #organoid research, #bioethics, and science education.
news.ucsc.edu/2025/10/lear...
news.ucsc.edu/2025/10/lear...
Effort aims to uncover the learning and reasoning potential of brain organoids
The Braingeneers team will to test the ability of brain organoids to solve tasks in real time
news.ucsc.edu
October 28, 2025 at 12:12 PM
In an NSF-supported study, @talsharf.bsky.social and collaborators will investigate the capacity of human brain organoids to learn and adapt, with implications for #organoid research, #bioethics, and science education.
news.ucsc.edu/2025/10/lear...
news.ucsc.edu/2025/10/lear...
Reposted by Tal Sharf
What if… spontaneous neural activity 🧠 reflects the baseline rumblings of a brainwide dynamical system initialized for learning? We find that the rumblings have macroscopic properties like those emerging from linear symmetric, critical systems 🧵 #neuroscience #neuroAI www.biorxiv.org/content/10.1...
January 12, 2025 at 7:55 PM
What if… spontaneous neural activity 🧠 reflects the baseline rumblings of a brainwide dynamical system initialized for learning? We find that the rumblings have macroscopic properties like those emerging from linear symmetric, critical systems 🧵 #neuroscience #neuroAI www.biorxiv.org/content/10.1...
Awesome work by @mrbadash.bsky.social and the crew at @ucscgenomics.bsky.social
Goal-directed learning in cortical #organoids
www.biorxiv.org/content/10.1...
Goal-directed learning in cortical #organoids
www.biorxiv.org/content/10.1...
Goal-Directed Learning in Cortical Organoids
Experimental neuroscience techniques are advancing rapidly, with major recent developments in high-density electrophysiology and targeted electrical stimulation. In combination with these techniques, ...
www.biorxiv.org
January 17, 2025 at 10:34 PM
Awesome work by @mrbadash.bsky.social and the crew at @ucscgenomics.bsky.social
Goal-directed learning in cortical #organoids
www.biorxiv.org/content/10.1...
Goal-directed learning in cortical #organoids
www.biorxiv.org/content/10.1...
Reposted by Tal Sharf
Our manuscript preprint is out!
Repetitive stimulation modifies network characteristics of neural organoid circuits https://www.biorxiv.org/content/10.1101/2025.01.16.633310v1
January 17, 2025 at 9:15 AM
Our manuscript preprint is out!
I’m thrilled to share our revised work on neuronal sequences in brain #organoids. It has been an absolute joy to collaborate with an incredible team of talented experimental and computational neuroscientists brought together by this project. www.biorxiv.org/content/10.1...
Protosequences in brain organoids model intrinsic brain states
Neuronal firing sequences are thought to be the basic building blocks of neural coding and information broadcasting within the brain. However, when sequences emerge during neurodevelopment remains unk...
www.biorxiv.org
January 9, 2025 at 7:26 PM
I’m thrilled to share our revised work on neuronal sequences in brain #organoids. It has been an absolute joy to collaborate with an incredible team of talented experimental and computational neuroscientists brought together by this project. www.biorxiv.org/content/10.1...